Before applying Lidocaine 20 mg / ml, it is mandatory to carry out a skin test for increased individual sensitivity to the drug, which is indicated by edema and redness of the injection site.
For local anesthesia apply injectively (subcutaneously, intramuscularly) and topically on mucous membranes. Avoid intravascular drug administration.
For conductive anesthesia (including for pain relief of the brachial and sacral plexus), the usual dose for adults is 5-10 ml of the solution (100-200 mg of lidocaine).
For anesthesia of fingers limbs, nose, and ear are injected with 2-3 ml of solution (40-60 mg of lidocaine).
The maximum dose of a solution of lidocaine for adults when used for conductive anesthesia is 10 ml (200 mg of lidocaine).
For terminal anesthesia, mucous membranes lubricate with a solution of Lidocaine in a volume of not more than 20 ml for adults in a dose of up to 2 mg / kg of body weight, the duration of anesthesia is 15-30 minutes. For superficial anesthesia of the mucous membranes of the nasal cavity, nasopharynx, larynx, oral cavity, esophagus, rectum, respiratory and urinary tract, the vagina is prescribed lubrication adult solution in dosage up to 2 mg / kg body weight; duration of anesthesia is 15-30 minutes. The maximum dose of the solution to adults is 20 ml. Intravenous 25 ml of 100 mg / ml solution diluted in 100 ml 0.9% sodium chloride solution to a concentration of lidocaine 20 mg / ml, which was used as a loading dose of 1-1.5 mg / kg (within 2-4 min at a rate of 25-50 mg / min) with immediate connection of a constant infusion at a rate of 1-4 mg / min. Because of the rapid distribution (T1/2 approximately 8 minutes), 10-20 minutes after the first dose, the concentration of the drug in the blood plasma decreases, which may require a repeated bolus administration (against a background of constant infusion) at a dose of 1 / 2-1 / 3 loading dose, with an interval of 8 -10 min. The maximum dose per hour is 300 mg, per day 2000 mg. Intravenous infusion is carried out for 12-24 hours with constant elektrokardiogramnym-monitoring, after which the infusion was stopped, to evaluate the need to change antiarrhythmic therapy in a patient. The elimination rate of the drug is reduced in chronic heart failure and liver dysfunction (cirrhosis, hepatitis), which requires reducing the dose and rate of administration of the drug to 25- 50%.Intravenously sprayed: children - 1 mg / kg (usually 50-100 mg) as a loading dose at a rate of 25-50 mg / min (that is, within 3-4 minutes); if necessary, the dose is repeated after 5 minutes, after which a continuous intravenous infusion is prescribed. Intravenously, as a continuous infusion (usually after a loading dose): the maximum dose for children is 30 μg / kg / min (20-50 μg / kg / min).