Active substanceIron [III] hydroxide polymaltosateIron [III] hydroxide polymaltosate
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  • Dosage form: & nbspsyrup
    Composition:

    5 ml of syrup contain iron [III] hydroxide polymaltosate 208.3 mg in terms of elemental iron 50 mg.

    Excipients:

    Sucrose, propyl parahydroxybenzoate, methyl parahydroxybenzoate, sorbitol 70%, cream essence, "golden taste" (vanillin, ethylvaniline, sucrose, butyric acid, butanedione, propylene glycol, purified water), purified water.

    Description:Dark brown viscous syrupy liquid with a characteristic specific odor.
    Pharmacotherapeutic group:The iron preparation
    ATX: & nbsp

    B.03.A.B   Preparations of iron (trivalent) for oral administration

    B.03.A.B.05   Iron hydroxide polymaltosate

    Pharmacodynamics:

    In the preparation Likferr100® iron is in the form of a complex compound of iron (III) hydroxide with polymaltose. This macromolecular complex is stable and does not release iron in the form of free ions. The complex is similar in structure to the natural iron-ferritin compound, the natural iron-storing protein that is contained in the body, so that ingestion of iron (III) from the intestine enters the blood by active absorption, which makes it practically impossible to overdose and poison the drug. Iron (III) hydroxide polymaltose complex does not possess the prooxidant properties that are inherent in iron salts (II). Transport of iron in plasma is carried out with the help of gamma-globulin transferrin, synthesized in the liver. Iron in combination with transferrin is transferred to the cells of the body, where it is used for the synthesis of hemoglobin, myoglobin and some enzymes. The absorbed iron is retained in the ferritin-related form, mainly in the liver.Trivalent iron participates in the formation of heme, which leads to an increase in the level of hemoglobin.

    Likferr100® syrup does not cause tooth staining.

    Indications:
    • Treatment of latent and clinically pronounced iron deficiency (iron deficiency anemia).
    • Prevention of iron deficiency, incl. during pregnancy, during lactation, in childbearing age in women, in children and adolescents, in people who follow a vegetarian diet.
    Contraindications:
    • Hypersensitivity.
    • Excessive iron content in the body (hemochromatosis).
    • Violation of the mechanisms of iron utilization (anemia caused by lead poisoning, sidero-achestic anemia).
    • Anemia, not associated with iron deficiency (hemolytic anemia, megaloblastic anemia).
    • Children weighing less than 5 kg.
    Pregnancy and lactation:During controlled studies in pregnant women (2nd - 3rd trimester of pregnancy), there was no adverse effect on the mother and fetus organisms. There was no adverse effect on the fetus when taking drugs in the first trimester of pregnancy.
    Dosing and Administration:

    Likferr100® syrup is intended for oral administration. The daily dose can be divided into several doses or taken once.It is recommended to take the syrup during or immediately after a meal. The syrup can be mixed with fruit and vegetable juices or with artificial nutrient mixtures, without fear of a decrease in the activity of the drug. The dosage of the drug and the timing of treatment depend on the degree of iron deficiency and are determined by the attending physician.

    With iron deficiency anemia, treatment lasts for 8-12 weeks before the hemoglobin is normalized. After this, the drug is prescribed for several more weeks to replenish the iron stores in the body at a dose corresponding to that for the treatment of latent iron deficiency.

    Daily doses of syrup Likferr100® for the prevention and treatment of iron deficiency conditions

    Category of patients

    Iron-deficiency anemia

    Latent iron deficiency

    Prevention of iron deficiency

    Children under 1 year old *

    2.5 - 5 ml

    **

    **

    Children from 1 year * to 12 years

    5 - 10 ml

    2.5 - 5 ml

    2.5 - 5 ml

    Children over 12 years of age, adults, nursing mothers

    10 - 30 ml

    5 - 10 ml

    5 - 10 ml

    Pregnant women

    20 - 30 ml

    10 ml

    10 ml

    Note: * provided that the body weight is more than 5 kg, since children with a body weight of less than 5 kg require a smaller dose, which is not provided by the measuring device;

    ** these indications require the appointment of smaller doses, which is not provided for by the measuring device.

    Side effects:

    Rarely.

    From the digestive system: in some cases - a feeling of overflow of the stomach, discomfort, nausea, constipation or diarrhea.

    When applying the drug, dark staining of the stool can appear, which is not of clinical significance.

    Overdose:

    In cases of drug overdose, no signs of intoxication or signs of excessive intake of iron into the body have been described to date.

    Interaction:

    No interaction with other drugs was noted.

    Special instructions:When prescribing the drug for patients with diabetes, it should be noted that 1 ml of syrup contains 0.04 bread units.
    Form release / dosage:

    Syrup, 50 mg / 5 ml.

    Packaging:

    150 ml in a bottle of polyethylene terephthalate brown, with the manufacturer's logo on the side of the bottle or in a bottle of light-protective glass, sealed with a screw cap made of aluminum with the logo of the manufacturer, and the control of the first autopsy.

    One bottle together with a measuring cup made of polypropylene with the logo of the manufacturer and instructions for use in a pack of cardboard.

    Storage conditions:

    At a temperature of no higher than 25 ° C in a dry place. Keep out of the reach of children.

    Shelf life:

    3 years.

    Do not use later than the date shown on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-000094
    Date of registration:31.05.2007 / 28.04.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:FarmSirma Soteks, ZAO FarmSirma Soteks, ZAO Russia
    Manufacturer: & nbsp
    Representation: & nbspPharm Company Sotex CJSC Pharm Company Sotex CJSC Russia
    Information update date: & nbsp25.02.2018
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