The most common undesirable reactions from the side of the organ of vision are allergic conjunctivitis, conjunctival hyperemia, itching of the eye mucosa and eyelid skin. Most of the undesirable reactions had a quick-passing nature and mild severity (do not require discontinuation of treatment). According to clinical studies, symptoms of allergic reactions from the eyes were observed in 12.7% of cases (being the reason for the termination of treatment in 11.5% of cases), while in most patients they manifested themselves in 3-6 months of application of the drug. The frequency of undesirable effects was classified as follows: very often (≥ 1/10), often (from ≥ 1/100 to <1/10), infrequently (from ≥ 1/1 000 to <1/100),rarely (from ≥ 1/10 000 to <1/1 000), very rarely (<1/10 000), the frequency of occurrence is unknown (it is impossible to estimate based on available data).
From the side of the organ of vision:
Often - congestion hyperemia, burning sensation, itchy eyelid skin and eye mucosa, foreign body sensation, impaired vision, allergic blepharitis, allergic blepharoconjunctivitis, allergic conjunctivitis, follicular conjunctivitis.
Often - hyperemia and edema of the eyelids, blepharitis, conjunctival edema and mucous discharge from the eyes, conjunctival hemorrhage, conjunctivitis, retinal lacrimation, epiphora, eye pain and lacrimation, conjunctival eye folliculosis, local allergic reactions of the eye mucosa (including keratoconjunctivitis), cataracts , keratitis, lesions of the eyelids, photosensitivity, superficial spotted keratopathy, loss of the visual field, functional damage of the vitreous humor, vitreous hemorrhage, floating opacities in the vitreous humus barely and reduced visual acuity, photophobia, erosion and opacity of the cornea, dryness and irritation of the mucous membrane of the eye surface, blanching of the conjunctiva.
Infrequently - barley.
Rarely - Irit, miosis.
From the central nervous system:
Often - headache, drowsiness.
Often - dizziness, a violation of taste.
Infrequently - Depression.
Rarely - fainting, insomnia.
From the cardiovascular system:
Infrequently - palpitations / arrhythmias (including bradycardia and tachycardia).
Very rarely - increase or decrease in blood pressure.
On the part of the respiratory system:
Often - bronchitis, pharyngitis, cough, shortness of breath.
Infrequently dryness of the nasal mucosa.
Rarely - shortness of breath.
From the gastrointestinal tract:
Often - dryness of the oral mucosa.
Often - gastrointestinal disorders - dyspepsia.
From the skin and subcutaneous fat:
Often - rash.
Infectious and parasitic diseases:
Often - flu-like syndrome, infectious disease (chills and respiratory infection), rhinitis, sinusitis, incl. infectious.
From the immune system:
Infrequently - Systemic allergic reactions.
Laboratory indicators:
Often - hypercholesterolemia.
Others:
Often - fatigue.
Often - asthenia.
Children noted: apnea, bradycardia, lowering blood pressure, hypothermia, muscle hypotension, pallor, drowsiness, decreased attention (see section "With caution").
Post-marketing application of 2 mg / ml eye drops of brimonidine revealed unwanted reactions (indicated below), the source of which was spontaneous reports with an unknown population size, therefore indicate the frequency of their occurrence is not possible:
from the side of the organ of vision: iridocyclitis (anterior uveitis);
from the skin and subcutaneous fat: allergic reactions from the skin, including erythema, face swelling, itching, rash and vasodilation of the skin of the eyelid;
from the gastrointestinal tract: nausea.