Livolyuk-PB - instructions for use, dose, side effects, contraindications

Has a hyperosmotic, laxative effect, stimulates intestinal peristalsis, improves absorption of phosphates and Ca2 + salts, promotes the excretion of ammonium ions.

Under the influence of the drug, reproduction occurs Lactobacillus acidophilus, Lactobacillus bifidus In the intestines, under the influence of which lactulose is split into lactic acid (mainly) and partly formic and acetic acids. This increases the osmotic pressure and decreases the pH in the lumen of the large intestine, which leads to ammonia migration from the blood to the intestine, its ionization and retention, as well as an increase in the volume of fecal matter and increased intestinal motility. Excretion of bound ammonium ions occurs with the development of a laxative effect.

The action occurs 24-48 hours after the administration (the delay is due to the passage of the drug through the gastrointestinal tract).

Inhibits the formation and absorption of nitrogen-containing toxins in the proximal part of the colon.

Reduces the concentration of ammonium ions in the blood by 25-50%, reduces the severity of hepatic encephalopathy, improves mental state and normalizes electroencephalography. Reduces the reproduction of salmonella.

Pharmacokinetics:

Absorption is low. Excretion by the kidneys - 3%.

Indications:

Hepatic precoma and coma, neencephalopathy, hyperammonemia, constipation (including chronic, with hemorrhoids, the need for surgery on the large intestine and / or anus),intestinal dysbiosis; enteritis caused by salmonella, shigella, salmonella; syndrome of putrefactive dyspepsia (in young children as a result of acute food poisoning); pain syndrome after removal of hemorrhoids; parodontosis.

Contraindications:Hypersensitivity, rectal bleeding nsdiagnosed, colo-, ileostoma, suspicion of appendicitis, galactosemia, intestinal obstruction.

Carefully:Diabetes.

Pregnancy and lactation:

Safety of lactulose for pregnant women and its effect on the fetus and the expectant mother have not been studied. Lactulose should be given to pregnant women only in cases where the expected benefit for a future mother outweighs the possible risks to the fetus. It is not known whether the lactulose in breast milk, and therefore caution should be exercised in the treatment of lactulose in nursing women.

Dosing and Administration:

Inside, with hepatic coma, precoma, encephalopathy and hyperammonemia - 30-50 ml 3 times a day, the daily dose can be 90-190 ml; then in an individually selected maintenance dose (providing a pH of feces 5-5.5) 2-3 times a day.

With constipation

Adults - in the first 3 days of 15-45 ml, then 10-30 ml.

Children up to 14 years - in the first 3 days 15 ml. then - 10 ml / day, up to 6 years - 5-10 ml/ cyr, Infants - 5 ml / day.

In the treatment of intestinal dysbiosis, putrefactive dyspepsia

Age	Daily dose
Children under 1 year old	1,5-3 ml
1 - 3 years	3 ml
4-7 years	5 ml
Older than 7 years and adults	10 ml

In the treatment of salmonellosis, shigellosis, salmonella - in the first 10-12 days to 15 ml 3 times a day, after one week break in the same dose, 5 times a day.

With periodontal disease for 15-30 ml / day.

Side effects:

Convulsions, flatulence, nausea, diarrhea, headache, dizziness, arrhythmia, myalgia, fatigue, weakness; with long-term treatment - violation of water-electrolyte metabolism.

Overdose:

If you use a very high dose, you may experience abdominal pain and diarrhea. In this case, it will be sufficient to reduce the dose or stop taking the drug.

Interaction:

Antibiotics (neomycin) and antacids reduce the effect.

Changes the pH-dependent release of finely soluble drugs.

It is not recommended to take lactulose within 2 hours after taking other medications.

Special instructions:

With prolonged admission (more than 6 months), control over the content of K⁺, FROMl^- Mr. SO₂ in the plasma.

With concomitant gastrocardial syndrome, you should gradually increase the dose to avoid flatulence (which disappears on its own for 2-3 days of treatment). In elderly and debilitated patients who take lactulose for more than 6 months, it is recommended to periodically measure the level of electrolytes in the blood serum. When diarrhea occurs, treatment is canceled.

In patients with portal systemic encephalopathy, electrolyte balance disorders may require intensive monitoring of electrolyte balance readings or other specific therapy.

Form release / dosage:

Syrup 10 g / 15 ml.

Packaging:

Primary packaging:

By 60 ml solution in bottles of dark glass or plastic bottles made of polyethylene terephthalate (PET) in dark color with a capacity of 70 ml.

For 100 ml of solution in bottles of dark glass or plastic bottles made of polyethylene terephthalate (PET) of dark color with a capacity of 105 ml.

For 200 ml of the solution in bottles of dark glass or plastic bottles made of polyethylene terephthalate (PET) in dark color with a capacity of 210 ml.

For 450 ml of solution in bottles of dark glass or plastic bottles made of polyethylene terephthalate (PET) of dark color with a capacity of 485 ml.

Secondary packaging:

The vials are sealed with a screw cap with protection from the first opening, along with a measuring plastic cup with a graduated calibration and instructions for use, placed in a cardboard box.

Storage conditions:

Store in a tightly sealed bottle at a temperature of 2 to 30 ° C.

Do not freeze.

Keep out of the reach of children.

Shelf life:

4 years (glass bottles).

3 years (plastic bottles).

Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-010037/09

Date of registration:09.12.2009 / 16.03.2016

Expiration Date:Unlimited

The owner of the registration certificate:Panacea Biotech Co., Ltd.Panacea Biotech Co., Ltd. India

Manufacturer: & nbsp

PANACEA BIOTEC, Ltd. India

Representation: & nbspPANACEA BIOTEC Co., Ltd. PANACEA BIOTEC Co., Ltd. India

Information update date: & nbsp28.02.2018

Illustrated instructions

Instructions

Lilium-PB (Livoluk-PB)