Lorinden® C (Lorinden® S)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceClioquinol + FlumethasoneClioquinol + Flumethasone
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  • Lorinden® C
    ointment externally 
    Pharmaceutical plant Elfa AO, Poland     Poland
  • Lorinden® C
    ointment externally 
    VALEANT, LLC     Russia
    • Dosage form: & nbspointment for external use
    Composition:

    1 g of ointment contains:

    active ingredients: flumethasone pivalate 0.20 mg, clioquinol 30.0 mg;

    Excipients: beeswax white 10.0 mg, petrolatum up to 1.0 g.

    Description:

    White with a light yellow or gray tinge grease. It is allowed to have single soft clusters of crystals.

    Pharmacotherapeutic group:Glucocorticosteroid for topical application + antifungal agent
    ATX: & nbsp

    D.07.B.01.01   Flumethasone in combination with antiseptics

    Pharmacodynamics:

    Lorinden® C is a combined preparation, the effect of which is due to the components that make up its composition. As a result of the combined effect of flumethasone and clioquinol (iodochloroquinoline), the drug inhibits the development of inflammatory-allergic skin reactions complicated by bacterial and fungal infection.

    Flumethasone is a synthetic bifluoride glucocorticosteroid for external use. Has anti-inflammatory, anti-allergic, antipruritic, decongestant and vasoconstrictive actions. When exposed to the skin occurs prevention of the edge accumulation of neutrophils, which leads to a decrease in inflammatory exudate and production of lymphokines, inhibition of migration of macrophages, a reduction in infiltration and granulation. Like other glucocorticosteroids flumethasone reduces the production of prostaglandins and leukotrienes by inhibiting the activity of phospholipase A2 and reducing the release of arachidic acid from the phospholipids of the cell membrane. Causes degeneration the main substance of connective tissue, weakens proliferative and exudative reactions in the skin. Has a local vasoconstrictive effect, which also reduces exudative reactions. It is an inhibitor of cellular kinins, which have proteolytic activity.

    Clioquinol (iodochlorooxyquinoline) is a derivative of 8-hydroxyquinolines. Active against dermatophytes and yeast fungi (Microsporum spp., Trichophyton spp., Candida albicans) Gram-positive bacteria (Staphylococcus spp., Enterococcus spp. ).

    Pharmacokinetics:

    After applying Lorinden® C ointment on the skin, the active components easily penetrate the stratum corneum of the epidermis.

    Flumethasone is practically not metabolized in the skin.After suction flumethasone, is mainly metabolized in the liver. It is excreted in the form of metabolites and a small amount in unchanged form through the kidneys and with bile.

    Clioquinol can be slightly absorbed through the skin and bind to plasma proteins. Partially biotransformed in the liver and excreted through the kidneys.

    Indications:

    Diseases of the skin complicated by a secondary bacterial and / or fungal infection caused by a clioquinol-sensitive flora:

    - allergic dermatitis;

    - contact dermatitis;

    - professional dermatitis;

    - seborrheic dermatitis;

    - sunny dermatitis;

    - atopic dermatitis;

    - prurigo; pruritis;

    - eczema;

    - exudative erythema multiforme;

    - psoriasis;

    - red flat herpes.

    Contraindications:

    - Hypersensitivity to the components of the drug;

    - viral skin diseases: herpes, chicken pox;

    - lupus;

    - cutaneous manifestations of syphilis;

    - neoplasms and precancerous skin conditions (skin cancer, nevus, atheroma, epithelioma, melanoma, hemangioma, xanthoma, sarcoma);

    - Acne vulgaris and rosacea;

    - perioral dermatitis;

    - trophic ulcers of the lower leg, associated with varicose veins;

    - condition after vaccination;

    - skin infections (for occlusive dressings);

    - children under 10 years old.

    Pregnancy and lactation:

    Controlled studies of possible teratogenic effects with topical application of flumethasone and iodochloroquinoline in pregnant women have not been carried out, therefore the use of the drug in the II and III trimesters of pregnancy is allowed in cases where the potential doctor's benefit for a pregnant woman prevails over the possible risk to the fetus. In these cases, the application should be short and limited to small areas of the skin.

    It is not recommended to use in the first trimester of pregnancy.

    Before feeding, the drug is not recommended to be applied to the skin of the breast.

    Dosing and Administration:

    Outwardly.

    Ointment is applied a thin layer on the affected areas. At the beginning of treatment the drug is used not more often 2-3 times a day, with the appearance of positive dynamics - 1-2 times a day.

    The drug should not be used for more than 2 weeks.

    If there is a need for bandages, a bandage that allows air to be used should be used.

    When excessive lichenization and hyperkeratosis ointment is used under the occlusive dressing once every 24-48 hours.Do not use the drug for more than 1 week.

    If it is not necessary, do not apply over a day more than 2 g of ointment.

    In adolescents over 10 years of age, use only in exceptional cases in limited areas of the skin, avoid applying the product to the skin of the face.

    Side effects:

    With the use of the drug are possible: burning, itching, steroid acne, striae, dry skin, folliculitis. With prolonged use - skin atrophy, local hirsutism, telangiectasia, purpura, pigmentation disorders; when applied to large surfaces, systemic manifestations of a glucocorticosteroid are possible.

    Overdose:

    Overdose is extremely rare. If the drug is applied incorrectly and for a long time on extensive skin surfaces, systemic side effects of flumethasone may occur.

    In the treatment of overdose, the drug is canceled gradually, and symptomatic therapy is prescribed.

    Interaction:

    During Lorinden's treatment® C should not be vaccinated and immunized due to the immunosuppressive effect of flumethasone.

    Do not administer in combination with other drugs for external use.

    When the drug is resorbed into the total bloodstream, flumethasone reduces the effectiveness of insulin, oral hypoglycemic drugs, antihypertensive drugs, anticoagulants, reduces the salicylates in the blood, reduces the concentration of praziquantel in the blood serum.

    Increase the risk of side effects: androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne), antipsychotic drugs, carbutamide, azathioprine (cataracts), holinoblokatory, antihistamines, tricyclic antidepressants, nitrates (glaucoma), diuretics (hypokalemia), cardiac glycosides (glycoside intoxication).

    Special instructions:

    Do not apply the product to the skin of the face. Do not exceed the course of treatment. Do not use for a long time on extensive skin areas. Avoid getting ointment in the eyes.

    With prolonged use of glucocorticosteroids in large areas of the skin, the incidence of side effects increases.

    When a secondary infection occurs at the site of application of the ointment, agents with a more pronounced antibacterial or antifungal effect should be used.

    Use with caution in patients with atrophic skin changes, especially in elderly people.

    With prolonged use, microorganisms resistant to clioquinol may appear.

    In fungal diseases with secondary allergy, the drug is used in exceptional cases, under medical supervision.

    Due to the fatty base, the ointment has a water repellent effect and forms a protective film that protects the skin from external moisture. Providing a deep fat-free and softening effect, ointment is most suitable for treating patients with dry and thin skin.

    Effect on the ability to drive transp. cf. and fur:

    The drug does not limit the psychophysical activity, the ability to drive vehicles and maintain machinery in motion.

    Form release / dosage:

    Ointment for external use.

    Packaging:

    For 15 grams in aluminum tubes with a varnished inner surface.

    The tube is placed in a cardboard box with instructions for use.

    Storage conditions:

    At a temperature of no higher than 25 ° C.

    In a place inaccessible to children.

    Shelf life:

    3 years.

    Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:P N014868 / 01-2003
    Date of registration:24.04.2009
    Expiration Date:Unlimited
    The owner of the registration certificate:Pharmaceutical plant Elfa AO, PolandPharmaceutical plant Elfa AO, Poland Poland
    Manufacturer: & nbsp
    Representation: & nbspPharmaceutical plant ELPHA A.O. Pharmaceutical plant ELPHA A.O. Poland
    Information update date: & nbsp19.03.2018
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