Side effects of frequency of occurrence are distributed as follows: very often (≥ 10%), often (≥ 1% and <10%), sometimes (≥ 0.1% and <1%), rarely (≥ 0.01% and < 0.1%), very rarely, including individual reports (<0.01%).
In patients with essential hypertension, the only side effect associated with taking the drug was dizziness, which was observed more often than with placebo and occurred in more than 1% of patients receiving Loxacor. In addition, less than 1% of patients had orthostatic reactions, depending on the dose of the drug. Rarely, rash was reported, but its incidence was less than with placebo.
Losacore is generally well tolerated by patients with left ventricular hypertrophy, patients with type 2 diabetes and proteinuria.The most frequent side effects associated with taking the drug were systemic and non-systemic dizziness, asthenia / weakness, marked decrease in blood pressure and hyperkalemia.
Side effects, occurring with a frequency of development of more than 1%:
From the body as a whole: pain in the stomach area of 1.7% (placebo 1.7%); weakness and fatigue 3.8% (placebo 3.9%), chest pain 1.1% (placebo 2.6%), peripheral edema 1.7% (placebo 1.9%).
From the side of the cardiovascular system: a palpitation of 1% (placebo 0.4%); tachycardia 1% (placebo 1.7%).
From the digestive system: diarrhea 1.9% (placebo 1.9%); dyspepsia 1.1% (placebo 1.5%); nausea 1.8% (placebo 2.8%).
From the side of the musculoskeletal system: back pain 1.6% (placebo 1.1%); muscle cramps 1% (placebo 1.1%).
From the central nervous system: dizziness 4.1% (placebo 2.4%); headache 14.1% (placebo 17.2%); Insomnia 1.1% (placebo 0.7%).
From the respiratory system: cough 3.1 (placebo 2.6%); edema of the nasal mucosa 1.3% (placebo 1.1%); pharyngitis 1.5% (placebo 2.6%); sinusitis 1% (placebo 1.3%); upper respiratory tract infection 6.5% (placebo 5.6%).
Side effects, occurring with a development rate of less than 1%:
Allergic reactions: angioedema, including laryngeal edema, glottis, causing airway obstruction and / or swelling of the face, lips, throat and / or tongue.
From the central nervous system: migraine.
From the side of the musculoskeletal system: myalgia, arthralgia.
From the skin: urticaria, itching.
From the digestive system: hepatitis, a violation of the liver.
On the part of the organs of hematopoiesis: anemia, thrombocytopenia.
From the respiratory system: cough.
Laboratory indicators: often: hyperkalemia (the concentration of potassium in the blood plasma is more than 5.5 meq / l); sometimes - increasing the concentration of urea and residual nitrogen or creatinine in the blood serum; very rarely - a moderate increase in the activity of "liver" transaminases: aspartate aminotransferase (ACT) and alanine aminotransferase (ALT), hyperbilirubinemia.
In patients with dehydration (eg, receiving diuretic treatment in high doses), at the beginning of treatment with losartan, symptomatic arterial hypertension may occur.
With cirrhosis of the liver, the concentration of losartan in the blood plasma increases significantly.
In general, the drug is well tolerated, the side effects are mild and transient and do not require withdrawal of the drug. The total frequency of Loxacor's side effects is comparable to that of placebo.