Mafusol (Mafusol)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePotassium chloride + Magnesium chloride + Sodium chloride + Sodium fumaratePotassium chloride + Magnesium chloride + Sodium chloride + Sodium fumarate
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  • Mafusol
    solution d / infusion 
    FIRM MEDPOLIMER, JSC     Russia
  • Sodium fumarate complex
    solution d / infusion 
    ESKOM NPK, OAO     Russia
    • Dosage form: & nbspsolution for infusions
    Composition:

    Sodium chloride 6.0 g, potassium chloride 0.3 g, magnesium chloride 0.12 g, sodium fumarate 14.0 g, water for injection up to 1.0 l.

    Description:

    Transparent colorless liquid.

    Pharmacotherapeutic group:Rehydrating agent
    ATX: & nbsp

    B.05.B.B   Solutions affecting the water-electrolyte balance

    B.05.B.B.01   Electrolytes

    Pharmacodynamics:

    Combined drug; has rehydrating, antiplatelet, antioxidant, diuretic and detoxifying effects. Activates the adaptation of the cell to a lack of oxygen; quickly replenishes the volume of circulating blood with hypovolemic conditions, prevents the dehydration of tissues, reduces the viscosity of the blood, improves its rheological properties, shows a hemodynamic effect.

    Indications:

    Hypovolemic and hypoxic conditions (blood loss, shock, trauma, intoxication).

    Acute disorders of cerebral circulation in adults, flowing through ischemic and hemorrhagic type.

    As a component of the perfusion mixture for filling the contour of the apparatus of artificial circulation in cardiosurgical operations in adults and children.

    Contraindications:

    Hypersensitivity to the components of the drug. Craniocerebral injury, accompanied by increased intracranial pressure, as well as conditions in which intravenous injection of large volumes of fluid is contraindicated (including heart failure).

    Dosing and Administration:Mafusol is used intravenously, intraarterially. The dose and rate of administration of the drug is chosen in accordance with the indications and condition of the patient. When shock (hemorrhagic, burn, traumatic, operating) of mild and moderate severity, adults Mafusol is administered in a dose of 2-3 liters, initially jet, and with the normalization of hemodynamic indicators - drip; in children at a dose of 20-25 ml / kg. In severe shock in adults Mafusol is recommended to be used in combination with erythrocyte-containing media, as well as colloid blood substitutes for hemodynamic action. The dose of Mafusol in this case is set individually, but not less than 1 liter; Children are injected at least 15 ml / kg.

    When severe intoxication in adults (peritonitis, sepsis, intestinal obstruction, etc.) is administered up to 2-3 l / day in combination with other detoxification agents; Children - 30-35 ml / kg / day.

    As a hemodiluent when refueling the artificial circulation apparatus, Mafusol can make up to 50% of the perfusion solution introduced into the apparatus.

    In cases of blood loss not exceeding 1% BCC in adults and children, the drug can be used as the only infusion medium.

    Mafusol can be used in place of other saline infusion solutions.

    Side effects:

    Allergic reactions.

    Overdose:

    If overdose is possible development of cerebral edema and pulmonary edema.

    Interaction:

    Mafusol can be used in combination with colloidal solutions (polyglucin, reopolyglucin, neohemodez, haemodes, gelatin, etc.); the drug is also compatible with donor blood, erythromass, plasma and other blood products.

    The use of Methosulf also does not interfere with the use of commonly used anti-shock drugs, including: drugs for neuroleptanalgesia (fentanyl, droperidol), preparations of benzodiazepine series (diazepam , etc.), as well as muscle relaxants (suxamethonium, etc.), inhibitors of proteolysis (aprotinin) and adrenomimetics (dopamine, epinephrine).

    Form release / dosage:

    Solution for infusion.

    Packaging:

    100, 200, 250, 400, 500 or 1000 ml into polymer containers for single-use infusion solutions with one or two ports made of polyvinylchloride or polyolefin films. Each container is packaged in a secondary bag with instructions for use. The secondary package is made of polypropylene or high-density polyethylene. Containers in the secondary packaging are placed in transport containers (corrugated cardboard boxes).

    Containers made of polyolefin film can be packed in transport containers (corrugated cardboard boxes) without a secondary package (for hospitals). Instructions for use are enclosed in the container box.

    Storage conditions:

    In a dry place at a temperature of no higher than 25 ° C. Freezing during transportation is allowed. In a place inaccessible to children.

    Shelf life:

    3 years. Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:P N000600 / 01
    Date of registration:30.07.2007 / 18.03.2013
    Expiration Date:Unlimited
    The owner of the registration certificate:FIRM MEDPOLIMER, JSC FIRM MEDPOLIMER, JSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp26.03.2018
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