Potassium chloride + Magnesium chloride + Sodium chloride + Sodium fumarate (Kalii chloridum + Magnii chloridum + Natrii chloridum + Natrii fumaras)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Regulators of water-electrolyte balance and KHS

Included in the formulation
  • Mafusol
    solution d / infusion 
    FIRM MEDPOLIMER, JSC     Russia
  • Sodium fumarate complex
    solution d / infusion 
    ESKOM NPK, OAO     Russia
    • АТХ:

    B.05.B.B   Solutions affecting the water-electrolyte balance

    B.05.B.B.01   Electrolytes

    Pharmacodynamics:

    Compensation of Na ions+, K+, Mg2+. Sodium fumarate - activation of cell adaptation to hypoxia due to participation in reversible oxidation and reduction reactions in the Krebs cycle and enhancement of synthesis adenosine triphosphate. The alkalizing effect (with metabolic acidosis), with hypovolemic conditions, rapid replenishment of the volume of circulating blood. Decrease of viscosity and improvement of rheological properties of blood. Strengthening diuresis. Activation of detoxification processes.

    Pharmacokinetics:

    There is no information. Calcium and magnesium ions penetrate the placental barrier and into breast milk. Excreted mainly by the kidneys, a small amount of sweat glands. 25-30% of magnesium ions bind to plasma proteins.

    Indications:

    As a plasma-substituting agent, for example, in case of shock, collapse, burns, hypothermia, prolonged vomiting, diarrhea. As a component of the perfusion mixture for filling the contour of the apparatus of the artificial circulation during cardiosurgery operations.

    ICD-10

    I.A00-A09.A05   Other bacterial food poisoning

    I.A00-A09.A09   Diarrhea and gastroenteritis of allegedly infectious origin

    IV.E70-E90.E86   Reduction of the volume of the liquid

    XVIII.R50-R69.R57.0   Cardiogenic shock

    XIX.T66-T78.T78.2   Anaphylactic shock, unspecified

    XIX.T79.T79.4   Traumatic shock

    Contraindications:

    Hypersensitivity; head trauma, accompanied by increased intracranial pressure; conditions in which intravenous administration of large volumes of fluid is counter-indicative (for example, arterial hypertension, severe heart failure).

    Carefully:

    For sodium chloride: with arterial hypertension, heart failure, peripheral edema or pulmonary edema, renal failure, pre-eclampsia and other conditions associated with the retention of sodium ions in the body.

    For potassium chloride: for heart diseases and conditions predisposing to hyperkalemia, such as renal or adrenal insufficiency, acute dehydration, massive damage to tissues (for example, with severe burns). It is necessary to regularly monitor the patient's condition, the content of electrolytes in the blood plasma (not to be used for hyperkalemia and hyperchloremia), ECG.

    For magnesium chloride: with caution in cardiac blockade and severe renal failure, myasthenia gravis gravis.

    Pregnancy and lactation:

    Adequate and well-controlled studies in humans and animals have not been carried out.

    Action category for the fetus by FDA - AT.

    Dosing and Administration:

    Intravenously struino and drip, less often - intraarterially; the dose and rate of administration depend on the indications and the condition of the patient.

    In the case of shock of mild and moderate severity, intravenously injected intravenously in a dose of 2-3 liters, after normalization of hemodynamic parameters, intravenously drip.

    In severe shock - at least 1 L in combination with erythrocyte-containing media or colloid blood substitutes for hemodynamic action.

    When severe intoxication - up to 2-3 liters per day in combination with other detoxification drugs.

    Side effects:

    Usually does not cause side effects.

    For sodium chloride side effects may be associated with electrolyte imbalance: hypernatremia, risk of pulmonary edema and peripheral edema; risk of reduction of bicarbonate buffer of blood with the subsequent development of acidosis.

    For potassium chloride: hyperkalemia, especially in renal failure.

    For magnesium chloride: hypersensitivity, hypermagnesia.

    Overdose:

    If the recommended volume of the solution is exceeded, hyperchloremic acidosis may develop.

    Interaction:

    Means that increase the content of potassium ions in the blood (potassium-sparing diuretics, ACE inhibitors, ciclosporin, medicines and nutritional supplements containing potassium salts) - the risk of hyperkalemia.

    Nonsteroidal anti-inflammatory drugs, androgens, estrogens, anabolic hormones, corticotropin, mineralocorticoids, vasodilators - the risk of hypernatremia.

    Calcium preparations, thiazide diuretics, vitamin D - the risk of hypercalcemia.

    Cardiac glycosides - the risk of developing glycosidic intoxication.

    Can be used in combination with colloidal solutions.

    Special instructions:

    In connection with the short-term effect of the drug, with pronounced hypovolemia, simultaneous administration of colloidal solutions, blood and its components is recommended.

    With prolonged administration of large amounts of solution, control of plasma and urine electrolyte concentrations is necessary.

    You can use instead of other polycomponent saline infusion solutions,in contrast to acetate and lactate-containing salt infusion media, it is also possible to appoint patients with extremely severe hypovolemia and hypoxia with phenomena of pronounced metabolic acidosis.

    The osmolarity of the solution is 400-410 mOsm / l.

    Instructions
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