Sodium fumarate complex (Sodium fumarate compound)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePotassium chloride + Magnesium chloride + Sodium chloride + Sodium fumaratePotassium chloride + Magnesium chloride + Sodium chloride + Sodium fumarate
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  • Mafusol
    solution d / infusion 
    FIRM MEDPOLIMER, JSC     Russia
  • Sodium fumarate complex
    solution d / infusion 
    ESKOM NPK, OAO     Russia
    • Dosage form: & nbspsolution for infusions
    Composition:

    Active components:

    Sodium chloride - 6.00 g

    Potassium chloride - 0.30 g

    Magnesium chloride hexahydrate (in terms of anhydrous) - 0.12 g

    Sodium fumarate - 14,00 g

    Excipients:

    Water for Injection - up to 1 liter

    Ionic composition (per 1 liter): sodium ion-275.0 mmol, potassium ion 4.0 mmol, magnesium ion 1.2 mmol, chloride ion 109.0 mmol, fumarate ion 86.2 mmol.

    Theoretical osmolality - 475.0 mOsmol / l.

    Description:

    Transparent colorless liquid.

    Pharmacotherapeutic group:Rehydrating agent
    ATX: & nbsp

    B.05.B.B   Solutions affecting the water-electrolyte balance

    B.05.B.B.01   Electrolytes

    Pharmacodynamics:

    Combined drug; has rehydrating, antiaggregant, antioxidant, diuretic and detoxifying action. Activates the adaptation of the cell to a lack of oxygen; quickly replenishes the volume of circulating blood with hypovolemic conditions, prevents dehydration of tissues, reduces blood viscosity, improves its rheological properties, shows a hemodynamic effect.

    Indications:

    Hypovolemic and hypoxic conditions (blood loss, shock, trauma, intoxication). Acute disorders of cerebral circulation in adults, flowing through ischemic and hemorrhagic type. As a component of the perfusion mixture for filling the contour of the apparatus of artificial circulation in cardiosurgical operations in adults and children.

    Contraindications:

    Hypersensitivity to the components of the drug. Craniocerebral injury, accompanied by increased intracranial pressure, as well as conditions in which intravenous injection of large volumes of fluid is contraindicated (including heart failure).

    Dosing and Administration:

    Intravenously struino and drip, less often intraarterially, the dose and rate of administration of the drug is chosen in accordance with the indications and condition of the patient.

    With shock (hemorrhagic, burn, traumatic, operating) of mild and moderate severity, adults Sodium fumarate complex is administered in a dose of 2-3 liters, initially jet, and with the normalization of hemodynamic indicators - drip; in children - in a dose of 20-25 ml / kg.

    In severe shock in adults Sodium fumarate complex is recommended to be used in combination with erythrocyte-containing media, as well as colloid blood substitutes for hemodynamic action.The dose of the drug in this case is set individually, but not less than 1 liter; Children are injected at least 15 ml / kg.

    In severe intoxications in adults (peritonitis, sepsis, intestinal obstruction, etc.), inject up to 2-3 l / day in combination with other detoxification drugs; Children - 30-35 ml / kg / day.

    As a hemodiluent when refueling the artificial circulation apparatus Sodium fumarate complex can constitute up to 50% of the perfusion solution introduced into the apparatus.

    In cases of blood loss not exceeding 15% of the volume of central blood flow in adults and children, the drug can be used as the only infusion medium.

    Sodium fumarate complex can be used in place of other saline infusion solutions.

    Side effects:

    Allergic reactions, cerebral edema, pulmonary edema, respiratory arrest (obliquity of the medulla oblongata).

    Overdose:Too fast administration with the use of large doses can lead to the development of acute left ventricular failure.
    Interaction:

    Sodium fumarate complex can be used in combination with colloidal solutions (polyglucin, reopolyglucin, neohemodez, haemodez, gelatin, etc.); the drug is also compatible with donor blood, erythromass, plasma and other blood products.

    Do not interfere with the appointment of commonly used anti-shock drugs, including. drugs for neuroleptanalgesia (fentanyl, droperidol), preparations of benzodiazepine series (diazepam, etc.), as well as muscle relaxants (suxamethonium, etc.), inhibitors of proteolysis (aprotinin) and adrenomimetics (dopamine, epinephrine).

    Special instructions:

    A regular blood test should be performed to determine electrolytes, pH and pCO2, the volume of circulating blood.

    Form release / dosage:

    Solution for infusion.

    Packaging:

    For 200 or 400 ml in glass bottles of MTO grade for blood, transfusion and infusion preparations, with a capacity of 250, 450 and 500 ml, respectively.

    1 bottle with instruction for use is placed in an individual pack of cardboard.

    For 15 bottles with a capacity of 450 ml and 500 ml or 28 bottles with a capacity of 250 ml with 5 or 10 instructions for use, respectively, in corrugated cardboard boxes (for hospitals).

    Storage conditions:

    List B. In the dark place at a temperature of 0 ° C to 25 ° C. Keep out of the reach of children. Freezing during transportation is allowed.

    Shelf life:

    2 of the year.Do not use after the expiration date printed on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-000268/09
    Date of registration:19.01.2009
    Expiration Date:Unlimited
    The owner of the registration certificate:ESKOM NPK, OAO ESKOM NPK, OAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp14.06.2018
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