Included in the formulation
АТХ:A.11.J.B Vitamins in combination with mineral substances
Pharmacodynamics:Pharmacological action is due to the pharmacological properties of magnesium and pyridoxine hydrochloride.
Magnesium is involved in the transport, storage and utilization of energy, the synthesis of proteins and nucleic acids in a number of mitochondrial processes; is an obligatory participant in the synthesis of neuropeptides in the brain, cofactor of many enzymatic reactions; controls the balance of intracellular potassium, is a part of 13 metalloproteins and more than 300 enzymes. Deficiency of magnesium in the body is manifested by muscle weakness, tremor, tetany, ataxia, increased reflex excitability, irritability, sleep disorders, heart rhythm disturbances.
Pyridoxine hydrochloride participates as a coenzyme in protein metabolism and synthesis of neurotransmitters, improves lipid metabolism in atherosclerosis. Entering the body, phosphorylated, converted to pyridoxal-5-phosphate, is part of the enzymes that perform decarboxylation and reamination of amino acids, facilitates the transport of amino acids through the cell membrane.It plays an important role in the metabolism of tryptophan, glutamic acid, cysteine, methionine. Pyridoxine is necessary for the activation of phosphorylase, for the formation of neurotransmitters, gamma-aminobutyric acid, glycine, serotonin. Participates in the metabolism of vitamin B12, folic acid, in the synthesis of porphyrins, in the exchange of unsaturated fatty acids.
Vitamin B6 and magnesium supplement each other's pharmacological action. B6 increases the concentration of magnesium in plasma and in erythrocytes and reduces the amount of magnesium withdrawn from the body; improves the absorption of magnesium from the digestive tract and its penetration into the cells, promotes the increase and fixation of intracellular magnesium. Magnesium activates the process of transformation of pyridoxine into its active metabolite pyridoxal-5-phosphate in the liver.
Pharmacokinetics:The absorption of magnesium in the gastrointestinal tract is 50% of the ingested dose. In the body, about 99% of magnesium is distributed mainly in the intracellular space. The main way to excrete magnesium is the urinary system. Excretion obeys the circadian rhythm with preferential excretion at night and is regulated by the digestive canal, kidneys and bone tissue.
Pyridoxine hydrochloride is absorbed in the small intestine, with blood flow spread to tissues and, penetrating into cells, is phosphorylated with the participation of ATP and pyridoxalkinases. The decomposition of coenzymes is carried out by dephosphorylation and oxidation in tissues. The main product of catabolism is 4-pyridoxic acid, which is excreted in urine.
Indications:Defined magnesium deficiency, isolated or associated with other conditions.
IV.E50-E64.E61.2 Magnesium deficiency
Contraindications:Hypersensitivity to the components of drugs, marked renal failure (creatinine clearance less than 30 ml / min), phenylketonuria, children's age.
Carefully:With moderate failure of kidney function, as there is a risk of hypermagnesemia.
Pregnancy and lactation:During pregnancy can be used only on the advice of a doctor.
Considering that magnesium penetrates into breast milk ,. should be avoided during breastfeeding.
Action category for the fetus by FDA - not determined. Adequate and well-controlled studies in humans and animals have not been conducted.
Dosing and Administration:Adults inside magnesium citrate 700 mg (which corresponds to 100 mg of magnesium) + pyridoxine hydrochloride 10 mg 2-3 times / day. Take with food, washing down a glass of water. Duration of treatment - 1-2 months. Treatment should be discontinued after the normalization of the magnesium concentration in the blood.
Side effects:Allergic reactions to the components of drugs. Disorders from the digestive tract (diarrhea, abdominal pain, constipation, nausea, vomiting, flatulence).
Overdose:Symptoms of an overdose: a drop in blood pressure, nausea, vomiting, slow reflexes, respiratory depression, coma, cardiac arrest and paralysis of the heart, anuria.
Treatment: rehydration, forced diuresis. With renal failure, hemodialysis or peritoneal dialysis is necessary.
Interaction:When using other drugs, you should always inform the doctor about it or consult with him
Simultaneous use of drugs containing phosphates or calcium salts can significantly reduce absorption of magnesium in the digestive tract. Magnesium preparations reduce the absorption of tetracycline, it is recommended to make an interval of 3 hours before using a combination of magnesium citrate with pyridoxine.
Magnesium weakens the effect of oral thrombolytic agents, reduces the absorption of iron.
Special instructions:In the case of concomitant calcium deficiency, magnesium deficiency should be eliminated before additional calcium intake is initiated.
With frequent use of laxatives, alcohol, increased physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.
Does not affect the ability to drive vehicles and mechanisms.