Magwith (Magvit)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceMagnesium citrate + PyridoxineMagnesium citrate + Pyridoxine
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  • Magwith
    capsules inwards 
    MINSKINTERKAPS, UP     Republic of Belarus
  • Magnelis® B6 forte
    pills inwards 
    OTISIFARM, OJSC     Russia
    • Dosage form: & nbspcapsules
    Composition:

    1 capsule contains:

    Active substances: pyridoxine hydrochloride - 5.0 mg, magnesium citrate - 350.0 mg (in terms of magnesium - 50.0 mg).

    Excipients: potato starch - 45.2 mg, magnesium stearate - 2.5 mg, lactose - a sufficient amount to obtain the contents of a capsule weighing 500.0 mg.

    Composition of the shell of gelatin capsulesGelatin - 81,19 mg, glycerol - 0,122 mg, purified water - 13,92 mg, sodium lauryl sulfate - 0,056 mg, titanium dioxide - 0,644 mg, dye: quinoline yellow E-104-0.055 mg, dye: sunset yellow E -110 - 0.013 mg.

    Description:

    Capsules hard gelatinous №0 yellow.

    The contents of capsules are white or white powder with a light yellowish or grayish hue of color.

    Pharmacotherapeutic group:Magnesium preparation
    ATX: & nbsp

    A.11.J.B   Vitamins in combination with mineral substances

    Pharmacodynamics:

    Pharmacological properties of the drug are due to the pharmacological properties of magnesium and pyridoxine hydrochloride.

    Magnesium is involved in the transport, storage and utilization of energy, the synthesis of proteins and nucleic acids in a number of mitochondrial processes; is a cofactor of many enzymatic reactions; controls the balance of intracellular potassium.

    Magnesium is an obligatory participant in the synthesis of all neuropeptides in the brain. He is a member of metalloproteins 13, more than 300 enzymes, including glutationsintetazy which converts glutamate to glutamine. Magnesium is involved in the synthesis of nucleic acids and proteins in the nucleus and ribosomes, participates in DNA replication and RNA transcription.

    Deficiency of magnesium in the body is manifested by muscle weakness, tremors, tetany, ataxia, increased reflex excitability, irritability, sleep disorders, heart rhythm disorders, and diarrhea. With secondary magnesium deficiency, clinical symptoms are diverse and often have a nonspecific character.

    Pyridoxine hydrochloride participates as a coenzyme in protein metabolism and synthesis of neurotransmitters, improves lipid metabolism in atherosclerosis. Entering the body, it is phosphorylated, converted to pyridoxal-5-phosphate, is part of the enzymes that perform decarboxylation and reamination of amino acids and facilitates the transport of amino acids through the cell membrane. It plays an important role in the metabolism of tryptophan, glutamic acid, cysteine, methionine. Pyridoxine is necessary for the activation of phosphorylase, for the formation of neurotransmitters, gamma-aminobutyric acid, glycine, serotonin. It participates in the exchange of vitamin B12, folic acid, in the synthesis of porphyrins, in the exchange of unsaturated fatty acids. The use of a combination drug containing magnesium and vitamin B6, is justified for the following reasons:

    - vitamin B6 and magnesium supplement each other's pharmacological action;

    - B6 increases the concentration of magnesium in plasma and in erythrocytes and reduces the amount of magnesium withdrawn from the body;

    - B6 improves absorption of magnesium from the digestive tract and its penetration into cells;

    - magnesium activates the process of transformation of pyridoxine into its active metabolite pyridoxal-5-phosphate in the liver;

    - B6 promotes increase and fixation of intracellular magnesium.

    Pharmacokinetics:The absorption of magnesium in the gastrointestinal tract is 50% of the ingested dose. In the body, magnesium is distributed mainly in the intracellular space (about 99%). The main way to excrete magnesium is the urinary system. Excretion obeys the circadian rhythm with preferential excretion at night and is regulated by the digestive canal, kidneys and bone tissue.Pyridoxine hydrochloride is absorbed in the small intestine, with blood flow spread to tissues and, penetrating into cells, is phosphorylated with the participation of ATP and pyridoxalkinases. The decomposition of coenzymes is carried out by dephosphorylation and oxidation in tissues. The main product of catabolism is 4-pyridoxic acid, which is excreted in urine.
    Indications:Defined magnesium deficiency, isolated or associated with other conditions.
    Contraindications:Hypersensitivity to the components of the drug, marked renal failure (creatinine clearance less than 30 ml / min), phenylketonuria, children's age.
    Carefully:With moderate failure of kidney function, as there is a risk of hypermagnesemia.
    Pregnancy and lactation:During pregnancy, the drug can be used only on the advice of a doctor. Magnesium penetrates into breast milk. Avoid the use of the drug during breastfeeding.
    Dosing and Administration:

    Before taking the drug, you should consult your doctor.

    Adults take 2 capsules 2-3 times a day. Duration of treatment -1-2 months.

    Capsules are taken with food, washed down with a glass of water.

    Treatment should be discontinued after the normalization of the magnesium concentration in the blood.

    Side effects:Allergic reactions to the components of the drug. Disorders from the gastrointestinal tract (diarrhea, abdominal pain, constipation, nausea, vomiting, flatulence).
    Overdose:

    Overdose Symptoms: a drop in blood pressure, nausea, vomiting, slow reflexes, respiratory depression, coma, cardiac arrest and paralysis of the heart, anuria.

    Treatment: rehydration, forced diuresis. With renal failure, hemodialysis or peritoneal dialysis is necessary.

    Interaction:

    When using other medicines, you should always inform the doctor about it, or consult a doctor or pharmacist about the possibility of using the drug "Magvit".

    Simultaneous use of drugs containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the gastrointestinal tract.

    Magnesium preparations reduce the absorption of tetracycline, it is recommended to make an interval of 3 hours before using Magvit.

    Magnesium weakens the effect of oral thrombolytic agents, reduces the absorption of iron.

    Special instructions:

    In case of concomitant calcium deficiency, magnesium deficiency should be eliminated before the introduction of additional calcium intake.

    With frequent use of laxatives, alcohol, increased physical and mental stress, the need for magnesium increases, which can lead to the development of a deficiency of magnesium in the body.

    Effect on the ability to drive transp. cf. and fur:Does not affect.
    Form release / dosage:Capsules.
    Packaging:

    10 capsules per contour cell packaging made of polyvinylchloride film and aluminum foil printed lacquered.

    For 3 or 5 contour squares, together with the instructions for use, they are placed in a pack of cardboard.

    Storage conditions:

    Store in a dry, dark place at a temperature of 15 to 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years.

    Do not use after the expiry date printed on the package.

    Terms of leave from pharmacies:Without recipe
    Registration number:LP-000338
    Date of registration:22.02.2011 / 30.06.2016
    Expiration Date:Unlimited
    The owner of the registration certificate:MINSKINTERKAPS, UP MINSKINTERKAPS, UP Republic of Belarus
    Manufacturer: & nbsp
    MINSKINTERKAPS, UP Republic of Belarus
    Information update date: & nbsp21.03.2018
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