Intravenously (slowly drip or drip). The dose of the drug administered depends on the age, weight, condition of the patient and concomitant therapy.
Prophylactic dose is 0.5 g / kg body weight, therapeutic dose is 1.0-1.5 g / kg; daily dose should not exceed 140-180 g.
Before the introduction, the preparation should be heated to a temperature of 37 ° C (it is possible in a water bath).
Patients with oliguria or suspected renal failure should be injected intravenously with a drip test dose (200 mg / kg body weight) for 3-5 minutes. The response to the test dose is considered sufficient if the diuresis level within 2-3 hours after the administration is 30-50 ml / h. In the absence of an adequate response, repeated administration of the test dose is possible. If there is no effect after repeated administration from the further use of the drug should be discarded.
In acute renal failure, the daily intake for adults is 50-180 g mannitol. In most cases, an adequate therapeutic effect is achieved with 50-100 g per day. Initially, administered at a dose of 200 mg / kg for 5 minutes; then the dose and rate of administration is adjusted to maintain diuresis at level 3 (-50 ml / h.
For the prevention of intra- and postoperative renal ischemia and associated acute renal failure mannitol Introduce in a dose of 50-100 g during or immediately after surgery.
To prevent hemolysis during operations with extracorporeal circulation preparation is administered in the heart-lung machine at a dose of 20-40 g immediately before perfusion.
In order to reduce elevated intraocular pressure mannitol dose is 1.5-2,0 g / kg body weight, which is administered by infusion over 30-60 minutes. When preparing a patient for ophthalmic surgery to achieve maximum effect mannitol in a dose of 1.5-2.0 g / kg administered for 1-1,5 hours before surgery.
For the reduction of elevated intracranial pressure and cerebral edema treating clinical effect achieved with the use of a dose 0.25-0.5 g / kg, which is administered no more frequently than every 6-8 hours.
To ensure forced diuresis (poisoning with drugs, medicaments, chemicals and noxious substances, posttransfuzioinyh complications incompatible blood after administration) the initial loading dose is about 25 g, more correct dose of the drug considering maintain diuresis at 100 ml / hour.