Intravenously (slowly drip or drip).
The dose of the drug administered depends on the age, weight, condition of the patient and concomitant therapy.
In acute renal failure, the daily intake for adults is 50-180 g mannitol. In most cases, an adequate therapeutic effect is achieved with a dose of 50 to 100 g per day. The maximum infusion rate, during the first 5 minutes, can be 200 mg / kg, later, the intravenous drug should be adjusted to maintain a diuresis of 30-50 ml per hour with a maximum daily dose of 180 g. For children, the administered dose is 0, 25-1.0 g / kg body weight.If necessary, repeated administration of the drug in the same dose after 4-8 hours is possible. Patients with oliguria or with suspected renal failure require the administration of a test dose (approximately 200 mg / kg body weight) for 3-5 minutes. The answer to the test dose is considered sufficient if the level of diuresis in the next 2-3 hours is 30-50 ml / h. In the absence of an adequate response, it is possible to re-administer the test dose, but if the effect is not achieved and when repeated administration, treatment with mannitol should be discontinued.
With increased intracranial pressure, brain edema, the dose of mannitol for adults and children is 1.5 to 2 g / kg body weight, for 30-60 minutes.
When preparing a patient for surgical intervention, mannitol should be administered 1-1.5 hours before surgery, to achieve maximum effect. In operations with artificial circulation, 20-40 g of mannitol are injected into the apparatus immediately before the start of perfusion.
To ensure forced diuresis for poisoning with barbiturates, salicylates, postinfusion complications, the dose of mannitol should be adjusted to maintain diuresis at 100 ml / h.The initial loading dose may be about 25 g.