Metamizol sodium + Caffeine + Thiamine (Coffeinum + Methamizolum natrium + Thiaminum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
Read on
Clinical and pharmacological group: & nbsp

Non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs

Vitamins and vitamin-like remedies

Psychostimulants

Included in the formulation
  • Sedalgin® Plus
    pills inwards 
       
    • АТХ:

    N.02.B.B.72   Metamizole sodium in combination with psycholeptics

    Pharmacodynamics:

    Combined drug that provides analgesic, antipyretic and anti-inflammatory action. Caffeine has a psychostimulating and antimigraine effect. Thiamine improves nerve reflex regulation.

    Pharmacokinetics:

    Metamizole sodium is rapidly and completely absorbed from the gastrointestinal tract. Maximum concentration in plasma is achieved on average 60-90 minutes after administration. It binds to plasma proteins and undergoes metabolism in the liver. Along the path of nonenzymatic hydrolysis, it is cleaved to 4-methylaminoantipyrine with further metabolism through active 4-aminoantipyrine to 4-acetylaminoantipyrine, the main metabolite, 90% of which is excreted by the kidneys and 10% by bile. Half-life is about 10 hours.

    Caffeine, which is part of the drug, is almost completely absorbed from the gastrointestinal tract. Maximum concentration in plasma is determined after 30-40 minutes. Quickly passes through the blood-brain and placental barrier. Penetrates into breast milk.It is excreted mainly by the kidneys in unchanged form and in the form of metabolites.

    The absorption of thiamine is high and occurs throughout the small intestine. Before sucking thiamine hydrochloride is released from the bound state by digestive enzymes. In the blood, the thiamine hydrochloride concentration is relatively low. In plasma, a predominantly free thiamine, in erythrocytes and leukocytes - its phosphoric esters. Half of the total is contained in the striated muscles (including the myocardium) and about 40% in the internal organs. Phosphorylation occurs in the liver. The most active phosphoric ester is thiamine diphosphate, which has coenzyme activity. It accumulates mainly in the liver, heart, brain, kidneys, spleen. It is excreted through the intestines and kidneys.

    Indications:

    Moderate or mild pain syndrome: headache (including migraine), toothache, neuralgia, myalgia, arthralgia, radicular syndrome, algodismenorea; renal, biliary and intestinal colic (as part of combination therapy with m-holinoblokatorami or other antispasmodic drugs).

    Feverish syndrome with catarrhal and other infectious-inflammatory diseases (with established diagnosis).

    ICD-10

    VI.G40-G47.G43   Migraine

    X.J00-J06.J06.9   Acute upper respiratory tract infection, unspecified

    X.J10-J18.J10   Influenza caused by an identified influenza virus

    XI.K00-K14.K08.8   Other specified changes in teeth and their supporting apparatus

    XIII.M20-M25.M25.5   Pain in the joint

    XIII.M50-M54.M54.1   Radiculopathy

    XIII.M50-M54.M54.3   Sciatica

    XIII.M50-M54.M54.4   Lumbago with sciatica

    XIII.M70-M79.M79.1   Myalgia

    XIII.M70-M79.M79.2   Neuralgia and neuritis, unspecified

    XIV.N80-N98.N94.5   Secondary dysmenorrhea

    XIV.N80-N98.N94.4   Primary dysmenorrhea

    XVIII.R50-R69.R50   Fever of unknown origin

    XVIII.R50-R69.R51   Headache

    XVIII.R50-R69.R52.0   Acute pain

    XVIII.R50-R69.R52.2   Another constant pain

    Contraindications:

    Individual intolerance, including other derivatives of pyrazolone (tribuzone).

    Bronchospasm.

    Deficiency glucose-6-phosphate dehydrogenase.

    Inhibition of bone marrow hematopoiesis.

    Insomnia.

    Severe hypertension.

    Severe atherosclerosis.

    Increased intraocular pressure.

    Pregnancy and lactation.

    Children's age (up to 12 years).

    Carefully:Renal and hepatic insufficiency.
    Pregnancy and lactation:

    The category of FDA recommendations is not defined.Adequate and well-controlled studies in humans and animals have not been conducted. The drug is prohibited for use during pregnancy and breastfeeding.

    Dosing and Administration:

    Inside (after eating) one tablet 2-3 times in the first half of the day; maximum single dose of 2 tablets, daily dose of 6 tablets.

    Without consulting a doctor, you can not take more than 3 days to treat a febrile syndrome and more than 5 days with a pain syndrome.

    Side effects:

    Allergic reactions (skin rash, itching, angioedema, bronchospasm, rarely anaphylactic shock).

    With prolonged admission, hematopoietic disorders (thrombocytopenia, leukopenia, agranulocytosis), sleep problems, palpitations, arrhythmias are possible.

    Overdose:

    When an overdose of nausea, vomiting, pain in the stomach, mental and motor excitement, violations of the heart rhythm, there may be a decrease in diuresis, convulsive syndrome. For treatment, gastric lavage is performed, adsorbents and symptomatic therapy are prescribed.

    Interaction:

    Non-narcotic analgesics with simultaneous use can lead to mutual enhancement of toxic effects.

    Tricyclic antidepressants, oral contraceptives drugs, allopurinol disrupt the metabolism of metamizole sodium in the liver, which leads to an increase in its toxicity.

    Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes reduce the effect of the drug.

    Simultaneous use leads to a decrease in the concentration of cyclosporine in the blood.

    Sedatives and tranquilizers increase the analgesic effect.

    Special instructions:

    Excessive consumption of tea and coffee during treatment can cause symptoms of an overdose. With therapy for more than one week, it is necessary to monitor the pattern of peripheral blood and the functional state of the liver.

    Instructions
    Up