Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):VED
ONLS
Pharmacodynamics:Coenzyme of enzymes that regulate protein and carbohydrate metabolism. Has a moderate ganglion-blocking effect, promotes the conduction of nerve impulses in synapses. It has an antioxidant effect, protects the cell membranes from the toxic effect of peroxidation products.
Pharmacokinetics:After oral administration, the fasting is almost completely absorbed in the gastrointestinal tract. It is distributed in all tissues: more than half of the total amount of the drug is contained in the striated muscle, about 40% - in the internal organs.
Metabolism in the liver by phosphorylation with the formation of thiamin diphosphate (cocarboxylase), which has a pharmacological effect.
Elimination by the kidneys and with feces.
Indications:It is used for vitamin B deficiency1, is used in the complex therapy of dystrophic myocardial lesions, polyneuritis, Wernicke's encephalopathy, opioid and alcohol dependence.
IV.E50-E64.E51 Insufficiency of thiamine
IV.E50-E64.E51.1 Take-Take
IV.E50-E64.E51.2 Encephalopathy Wernicke
XXI.Z40-Z54.Z50.2 Rehabilitation of people with alcoholism
V.F10-F19.F11 Mental and behavioral disorders caused by the use of opioids
VI.G60-G64.G60 Hereditary and idiopathic neuropathy
VI.G60-G64.G61 Inflammatory polyneuropathy
VI.G60-G64.G62.1 Alcoholic polyneuropathy
VI.G60-G64.G63.2 * Diabetic polyneuropathy (E10-E14 + with common fourth sign .4)
Contraindications:
Individual intolerance.
Carefully:Hypersensitivity to the drug.
Pregnancy and lactation:Recommendations for FDA - Category B. It is used in pregnancy and lactation.
Dosing and Administration:Inside for 100 mg 1 time / day. For treatment of opioid and alcohol dependence, 100 mg 2-3 times / day are prescribed.
The highest daily dose: 300 mg.
The highest single dose: 100 mg.
Side effects:Possible irritation of the mucous membrane of the gastrointestinal tract, manifested dyspeptic disorders.
Allergic reactions.
Overdose:Cases of overdose are not described.
Treatment is symptomatic.
Interaction:Enhances the effect of anticoagulants.
Impaired absorption of thiamine while using with bleomycin, vinblastine, fluorouracil, cisplastin.
The excretion of thiamine with simultaneous use with isoniazid and penicillamine is increased.
Sulfite-containing infusion solutions reduce the effects of thiamine.
Special instructions:Weaken the effect of depolarizing muscle relaxants. Before an operative intervention it is necessary to inform the anesthesiologist about taking the drug by the patient.