From the nervous system: sometimes there may be a feeling of fatigue, headache, dizziness, a sense of fear, anxiety, depression, drowsiness, tinnitus; in some cases, a dyskinetic syndrome may develop (involuntary tick-like twitching of the muscles of the face, neck or shoulders). Perhaps the appearance of extrapyramidal disorders: spasm of facial muscles, trismus, rhythmic protrusion of the tongue, bulbar type of speech, spasm of extraocular muscles (including oculogic crisis), spastic torticollis, opisthotonus, muscle hypertonia. With long-term treatment in some elderly patients, development of parkinsonism (tremor, twitching of muscles, limited mobility) is possible. In elderly patients with chronic renal failure, the development of tardive dyskinesia is also possible. In isolated cases, the development of malignant neuroleptic syndrome (characteristic signs: fever, muscle contracture, altered consciousness and increased blood pressure) is possible.
On the part of the hematopoiesis system: agranulocytosis.
From the cardiovascular system: supraventricular tachycardia, decreased or increased blood pressure.
From the gastrointestinal tract: constipation, diarrhea, dry mouth.
From the endocrine system: with long-term use of the drug in rare cases can occur gynecomastia (enlargement of the mammary glands in men), galactorrhea (spontaneous discharge of milk from the mammary glands), menstrual irregularities; in the development of these phenomena metoclopramide cancel.