Metoclopramide - instructions for use, dose, side effects, contraindications

Description:Tablets from white with kremovatym to white with a cream shade of color, flat-cylindrical shape with a facet and a risk, is allowed a slight marble.

Pharmacotherapeutic group:Antiemetics - dopamine receptor blocker central

ATX: & nbsp

A.03.F.A Motility stimulators GIT

A.03.F.A.01 Metoclopramide

Pharmacodynamics:

Metoclopramide is a specific blocker of dopamine (D₂) and serotonin receptors. Has antiemetic effect, eliminates nausea and hiccups.

The drug has a regulating and normalizing effect on the activity of the gastrointestinal tract. Reduces the motor activity of the esophagus, increases the tone of the lower sphincter of the esophagus, accelerates the emptying of the stomach, and accelerates the movement of food through the small intestine, without causing diarrhea.

Stimulates the secretion of prolactin.

Pharmacokinetics:

Quickly absorbed from the gastrointestinal tract.

Bioavailability ranges from 60% to 80%. The maximum concentration in the blood depends on the individual metabolism, the peak concentration in the blood is observed 1 to 2 hours after taking the drug.

The half-life is between 3 and 5 hours, with kidney failure - up to 14 hours. Removal of the drug occurs mainly through the kidneys for 24 hours in unchanged form and in the form of conjugates. Metoclopramide passes through the placental and blood-brain barrier and penetrates into the mother's milk.

Indications:Vomiting, nausea, hiccough of various genesis (in some cases can be effective in vomiting caused by radiation therapy or the use of cytotoxic drugs).Atony and hypotension of the stomach and intestines (in particular, postoperative); biliary dyskinesia; reflux esophagitis; flatulence; in the complex therapy of exacerbations of gastric ulcer and duodenal ulcer. It is used to enhance peristalsis during radiocontrast studies of the gastrointestinal tract.

Contraindications:Bleeding from the gastrointestinal tract, stenosis of the pylorus, mechanical intestinal obstruction, perforation of the wall of the stomach or intestine, pheochromocytoma, extrapyramidal disorders, epilepsy, prolactin-dependent tumors, pregnancy, lactation, age 6 years, hypersensitivity to metoclopramide or other components of the drug.

Carefully:Bronchial asthma, arterial hypertension, Parkinson's disease, hepatic and / or renal insufficiency, advanced age.

Pregnancy and lactation:Application during pregnancy and during lactation is contraindicated.

Dosing and Administration:Metoclopramide take inside for 30 minutes before eating, without chewing, drink with a small amount of water. Adults appoint 5 to 10 mg 3 to 4 times a day.The maximum single dose is 20 mg, the daily dose is 60 mg. Children over 6 years of age are prescribed 5 mg 1 to 3 times a day.

Side effects:At the beginning of treatment, constipation, diarrhea, dry mouth, fatigue, drowsiness, headache, dizziness, depression are possible. With long-term use of the drug in high doses, more often in elderly patients, there may be phenomena of parkinsonism, dyskinesia, in rare cases - galactorrhea, gynecomastia, menstrual irregularities.

Overdose:

There may be hypersomnia, disorientation and extrapyramidal disorders. As a rule, the symptomatology disappears after stopping the drug within 24 hours.

If necessary, central cholinergic blockers and anti-Parkinsonics are treated.

Interaction:The action of metoclopramide may weaken the anticholinesterase drugs. The drug enhances the absorption of tetracycline, ampicillin, paracetamol, acetylsalicylic acid, levodopa, ethanol; reduces the absorption of digoxin and cimetidine. Do not prescribe simultaneously with neuroleptics, because the risk of extra pyramidal reactions increases.

Special instructions:During the treatment with the drug, alcohol is not recommended.

Effect on the ability to drive transp. cf. and fur:When taking the drug should be avoided potentially dangerous activities that require increased attention, rapid mental and motor reaction (vehicle management, etc.).

Form release / dosage:Tablets 10 mg.

Packaging:10 tablets in a contour mesh box made of polyvinylchloride film and foil of aluminum printed lacquered or flexible packaging on the basis of aluminum foil. 1, 2 or 5 contour mesh packages together with instructions for use in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:2 years. Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N002081 / 01

Date of registration:25.12.2008 / 22.12.2014

Expiration Date:Unlimited

The owner of the registration certificate:MOSCOW ENDOCRINE FACTORY, FSUE MOSCOW ENDOCRINE FACTORY, FSUE Russia

Manufacturer: & nbsp

MOSCOW ENDOCRINE FACTORY, FSUE Russia

Information update date: & nbsp09.05.2018

Illustrated instructions

Instructions

Metoclopramide (Metoclopramide)