Metoclopramide-Acry - instructions for use, dose, side effects, contraindications

Pharmacodynamics:Antiemetic, is a specific blocker of dopamine (D2) and serotonin receptors. Has antiemetic effect, eliminates nausea and hiccups. Reduces the motor activity of the esophagus, increases the tone of the lower sphincter of the esophagus, accelerates the emptying of the stomach, and accelerates the movement of food through the small intestine, without causing diarrhea. Stimulates the secretion of prolactin.

Pharmacokinetics:Quickly absorbed from the gastrointestinal tract. Bioavailability is 60-80%. The time to reach the maximum concentration in the blood plasma is 1-2 hours. Half-lead time is from 3 to 5 hours, with renal dysfunction up to 14 hours. Removal of the drug occurs mainly by the kidneys for 24 hours in unchanged form and as conjugates . Passes through the placental and blood-brain barrier, penetrates into the mother's milk.

Indications:Vomiting, nausea, hiccough of different genesis, in some cases can be effective in vomiting caused by radiation therapy or cytotoxic therapy, atony and hypotension of the stomach and intestines (in particular,postoperative); biliary dyskinesia; reflux-esophagitis, flatulence, exacerbation of peptic ulcer of stomach and duodenum (as part of complex therapy), during radiocontrast studies of the gastrointestinal tract (to enhance peristalsis).

Contraindications:Hypersensitivity, bleeding from the gastrointestinal tract, stenosis of the pylorus of the stomach, mechanical intestinal obstruction, perforation of the wall of the stomach or intestine, pheochromocytoma, extrapyramidal disorders, epilepsy, prolactin-dependent tumors, pregnancy, lactation, children under 18 years.

Carefully:Bronchial asthma, arterial hypertension, Parkinson's disease, hepatic and / or renal insufficiency, advanced age.

Dosing and Administration:Inside. Adults - 10 mg 3-4 times a day for 30 minutes before meals, the tablet is swallowed whole and washed down with a small amount of water. The maximum single dose is 20 mg, the daily dose is 60 mg.

Side effects:Constipation or diarrhea, dry mouth, fatigue, drowsiness, headache, dizziness, depression.With long-term use of the drug in high doses, more often in elderly patients, there may be phenomena of parkinsonism, dyskinesia, galactorrhea, gynecomastia, menstrual irregularities.

Overdose:Symptoms: hypersomnia, disorientation and extrapyramidal disorders. Symptomatology disappears after discontinuation of the drug within 24 hours.

Interaction:

The action of metoclopramide may weaken the anticholinesterase drugs. Strengthens the absorption of tetracycline, ampicillin, paracetamol, acetylsalicylic acid, levodopa, ethanol; reduces the absorption of digoxin and cimetidine.

Do not appoint simultaneously with antipsychotic drugs (neuroleptics), as the risk of extrapyramidal reactions increases.

Special instructions:

During the period of treatment is not recommended to use ethanol.

If necessary, central anticholinergic drugs and other antiparkinsonian drugs are treated.

Effect on the ability to drive transp. cf. and fur:During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities,requiring increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Tablets 10 mg.

Packaging:

For 10 tablets in a planar cell package.

5 contour mesh packages together with instructions for use in a pack of cardboard.

Storage conditions:

In a dry, the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:3 years. Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N003212 / 01

Date of registration:13.04.2009 / 04.02.2010

Expiration Date:Unlimited

Date of cancellation:2016-10-04

The owner of the registration certificate:AKRIKHIN HFK, JSC AKRIKHIN HFK, JSC Russia

Manufacturer: & nbsp

AKRIKHIN HFK, JSC Russia

Information update date: & nbsp09.05.2018

Illustrated instructions

Instructions

Metoclopramide-Acry® (Metoclopramide-Akri)