On the part of the hematopoiesis system: anemia (including aplastic), thrombocytopenia, leukopenia, neutropenia, agranulocytosis, eosinophilia, pancytopenia, lymphoproliferative diseases, hypogammaglobulinemia, lymphadenopathy.
From the digestive system: anorexia, nausea, vomiting, stomatitis, gingivitis, pharyngitis, enteritis, erosive and ulcerative lesions and bleeding from the digestive tract (including melena, hematemesis), hepatotoxicity (acute hepatitis, fibrosis and cirrhosis, hepatic insufficiency, hypoalbuminemia, increased activity of the liver "transaminase), pancreatitis.
From the nervous system: headache, dizziness, drowsiness, dysarthria, aphasia, hemiparesis, paresis, seizures; when used in high doses - transient cognitive impairment, emotional lability; unusual cranial sensitivity, encephalopathy (including leukoencephalopathy).
From the side of the organ of vision: conjunctivitis, visual impairment (including transient blindness).
From the cardiovascular system: pericarditis, pericardial effusion, lowering blood pressure (BP), embolism (including arterial thrombosis, cerebral vascular thrombosis, deep vein thrombosis, retinal vein thrombosis, thrombophlebitis, pulmonary embolism).
From the respiratory system: rarely - pulmonary fibrosis, respiratory failure, alveolitis, interstitial pneumonitis (including fatal), chronic obstructive pulmonary disease (COPD), the symptoms of potentially serious interstitial pneumonia - dry non-productive cough, shortness of breath, fever.
From the genitourinary system: heavy nephropathy or renal insufficiency, azotemia, cystitis, hematuria, proteinuria, impaired spermato- and oogenesis, transient oligospermia, decrease in libido, impotence, dysmenorrhea, vaginal secretions, gynecomastia, infertility, miscarriage, fetal death, fetal defects.
From the skin: erythematous rash, itching, rash, photosensitivity, impaired skin pigmentation, alopecia, ecchymosis, telangiectasia, acne, abrasions, erythema multiforme (including Stevens-Johnson syndrome), toxic epidermal necrolysis, ulceration and necrosis of the skin, exfoliative dermatitis.In the treatment of psoriasis - a burning sensation of the skin, painful erosive plaques on the skin.
From the musculoskeletal system: arthralgia, myalgia, osteoporosis, osteonecrosis, fractures.
Neoplasms: lymphoma (including reversible).
Common reactions: allergic reactions up to anaphylactic shock, allergic vasculitis, tumor lysis syndrome, soft tissue necrosis, sudden death, life-threatening opportunistic infections (including pneumocystis pneumonia), cytomegalovirus (CMV) infections (including CMV pneumonia), sepsis including fatal), nocardiosis, histoplasmosis, cryptococcosis, infections caused by herpes zoster and herpes simplex (including disseminated herpes), diabetes mellitus, increased sweating.