Active substanceMetronidazoleMetronidazole
Similar drugsTo uncover
  • Bacimex
    solution d / infusion 
  • Clion
    solution d / infusion 
    GEDEON RICHTER, OJSC     Hungary
  • Clion
    pills inwards 
  • Metrowagin®
    suppositories the vagina. 
    ALTAYVITAMINS, CJSC     Russia
  • Metrogil®
    gel externally 
  • Metrogil®
    solution in / in 
  • Metrogil®
    gel the vagina. 
  • Metrogil®
    pills inwards 
  • Metrolacker
    solution d / infusion 
  • Metron
    solution d / infusion 
  • Metronidazole
    solution d / infusion 
  • Metronidazole
    solution d / infusion 
  • Metronidazole
    solution d / infusion 
    BIOSINTEZ, PAO     Russia
  • Metronidazole
    pills inwards 
    ATOLL, LLC     Russia
  • Metronidazole
    solution d / infusion 
  • Metronidazole
    pills inwards 
  • Metronidazole
    solution d / infusion 
  • Metronidazole
    pills inwards 
    MARBIOFARM, OJSC     Russia
  • Metronidazole
    suppositories the vagina. 
    DALHIMFARM, OJSC     Russia
  • Metronidazole
    pills inwards 
    UPDATE OF PFC, CJSC     Russia
  • Metronidazole
    pills inwards 
  • Metronidazole
    solution d / infusion 
    ELFA NPC, CJSC     Russia
  • Metronidazole
    solution d / infusion 
    DALHIMFARM, OJSC     Russia
  • Metronidazole
    pills inwards 
    DALHIMFARM, OJSC     Russia
  • Metronidazole
    suppositories the vagina. 
    AVEKSIMA, JSC     Russia
  • Metronidazole
    solution d / infusion 
  • Metronidazole
    solution d / infusion 
    RESTER, CJSC     Russia
  • Metronidazole
    pills inwards 
    ATOLL, LLC     Russia
  • Metronidazole
    gel the vagina. 
    SYNTHESIS, OJSC     Russia
  • Metronidazole
    pills inwards 
  • Metronidazole
    pills inwards 
  • Metronidazole
    solution d / infusion 
    KRASFARMA, JSC     Russia
  • Metronidazole
    pills inwards 
  • Metronidazole
    solution d / infusion 
  • Metronidazole
    solution d / infusion 
  • Metronidazole
    pills inwards 
    VALENTA PHARM, PAO     Russia
  • Metronidazole
    solution d / infusion 
  • Metronidazole
    pills inwards 
    AVEKSIMA, JSC     Russia
  • Metronidazole
    solution d / infusion 
    Kelun-Kazfarm, TOO     The Republic of Kazakhstan
  • Metronidazole
    gel externally 
    GREEN DUBRAVA, CJSC     Russia
  • Metronidazole
    solution d / infusion 
    Avexima Sibir, OOO     Russia
  • Metronidazole
    pills inwards 
    VELFARM, LLC     Republic of San Marino
  • Metronidazole MS
    pills inwards 
    MEDISORB, CJSC     Russia
  • Metronidazole Nycomed
    pills inwards 
    Takeda Pharma A / S     Denmark
  • Metronidazole-AKOS
    solution d / infusion 
    SYNTHESIS, OJSC     Russia
  • Metronidazole-Altpharm
    suppositories the vagina. 
    ALTFARM, LLC     Russia
  • Metronidazole-LekT
    pills inwards 
  • Metronidazole-Teva
    pills inwards 
  • Metronidazole-UBF
    pills inwards 
    URALBIOFARM, OJSC     Russia
  • Metronidazole-ESCO
    solution in / in 
    ESKOM NPK, OAO     Russia
  • TYUMENSK HFZ, FSUE     Russia
  • Metronidal®
    solution d / infusion 
    PREBAND PFC, LLC     Russia
  • Metroseptol
    gelcream externally 
  • Nirmet
    solution d / infusion 
  • Rosamet
    cream externally 
  • Rosex®
    gel externally 
  • Rosex®
    cream externally 
  • Siptrogyl
    solution d / infusion 
  • Tricho-PIN®
    pills inwards 
    NORTH STAR, CJSC     Russia
  • Trichobrol®
    pills inwards 
    BRYNTSALOV-A, CJSC     Russia
  • Trichopolol®
    solution d / infusion 
  • Trichopolol®
    pills inwards 
  • Trichopolol®
    pills the vagina. 
  • Trichosept
    suppositories the vagina. 
    BIOSINTEZ, PAO     Russia
  • Flagil®
    pills inwards 
  • Flagil®
    suppositories the vagina. 
  • Edgil
    solution d / infusion 
  • Efloran
    solution d / infusion 
  • Efloran
    pills inwards 
  • Dosage form: & nbspTabletki.
    Composition:

    For one tablet:

    active substance: metronidazole (in terms of metronidazole) - 0.25 g;

    Excipients: potato starch - 0.0275 g; carboxymethyl starch sodium (primogel) - 0.003 g; polyvinylpyrrolidone (povidone) - 0.0135 g; calcium stearate (calcium octadecanoate) - 0.023 g; talc - 0.0031 g.

    Description:

    Tablets are white or white with a yellowish-greenish hue of color, a flat-cylindrical shape with a facet and a risk.

    Pharmacotherapeutic group:antimicrobial and antiprotozoal agent
    ATX: & nbsp

    P.01.A.B   Nitroimidazole derivatives

    P.01.A.B.01   Metronidazole

    Pharmacodynamics:

    Antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group reacts with the deoxyribonucleic acid (DNA) of a cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.

    Active in a relationship Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp., as well as obligate anaerobes Bacteroides spp. (incl. Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (P.bivia, P.buccae, P.disiens), and some gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). The minimum inhibitory concentration for these strains is 0.125-6.25 μg / ml.

    In combination with amoxicillin shows activity against Helicobacter pylori (amoxicillin suppresses the development of resistance to metronidazole).

    To Metronidazole not sensitive Aerobic microorganisms and facultative anaerobes, but in the presence of mixed flora (aerobes and anaerobes) metronidazole acts synergistically with antibiotics effective against conventional aerobes.

    Increases the sensitivity of tumors to radiation, causes sensitization to alcohol (disulfiram-like action), stimulates reparative processes.

    Pharmacokinetics:

    Absorption is high (bioavailability is not less than 80%). It has a high penetrating ability, reaching bactericidal concentrations in most tissues and body fluids, including lungs, kidneys, liver, skin, cerebrospinal fluid, brain, bile, saliva, amniotic fluid, abscess cavities, vaginal secretion, seminal fluid, breast milk. Penetrates through the blood-brain and placental barrier. The volume of distribution: adults - about 0.55 l / kg, newborns - 0.54-0.81 l / kg.

    The maximum concentration of the drug in the blood (CmOh) is from 6 to 40 μg / ml, depending on the dose. Time to reach the maximum concentration (TCmOh) -1-3 hours. The connection with plasma proteins is 10-20%.

    In the body, about 30-60% of metronidazole is metabolized by hydroxylation, oxidation and glucuronation.The main metabolite (2-oxymetronidazole) also has antiprotozoal and antimicrobial effects.

    The half-life (T1/2) with normal liver function - 8 hours (6 to 12 hours), with alcoholic liver damage - 18 hours (from 10 to 29 hours), in newborns: those born at the time of pregnancy - 28-30 weeks - about 75 hours, respectively, 32-35 weeks - 35 hours, 36-40 weeks - 25 hours. It is excreted by the kidneys 60-80% (20% unchanged), through the intestine - 6-15%.

    Kidney clearance - 10.2 ml / min.

    In patients with impaired renal function after repeated administration of metronidazole cumulation in serum can be observed (hence patients with severe renal impairment receiving frequency to be reduced).

    Metronidazole and major metabolites are rapidly removed from the blood during hemodialysis (T1/2 is reduced to 2.6 h). When peritoneal dialysis is withdrawn in small quantities.

    Indications:

    Protozoal infections: intestinal amebiasis, including amoebic liver abscess, intestinal amoebiasis (amoebic dysentery), trichomoniasis, giardiasis, balantidiasis, giardiasis, cutaneous leishmaniasis, trichomonas vaginitis, trichomoniasis urethritis.

    Infections caused by Bacteroides spp. (including W. fragilis, AT. distasonis, AT. ovatus, AT. thetaiotaomicron, AT. vulgatus): infections of bones and joints, infections of the central nervous system (CNS), incl. meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess.

    Infections caused by the species Bacteroides, including group AT. fragilis, species Clostridium, Peptococcus and Peptostreptococcus: infection of the abdominal cavity (peritonitis, liver abscess), infection of the pelvic organs (endometritis, endomyometritis, abscess of the fallopian tubes and ovaries, vaginal vaginal infection after surgical operations), skin and soft tissue infections,

    Infections caused by the species Bacteroides, including group V. fragilis and species Clostridium: sepsis.

    Pseudomembranous colitis (associated with the use of antibiotics).

    Gastritis or duodenal ulcer associated with Helicobacter pylori, alcoholism.

    Prevention of postoperative complications (especially interference on the colon, near-rectal area, appendectomy, gynecological operations).

    Radiation therapy of patients with tumors - as a radiosensitizer, in cases where tumor resistance is caused by hypoxia in tumor cells.

    Contraindications:

    Hypersensitivity, leukopenia (incl.in anamnesis), organic lesions of the central nervous system (including epilepsy), liver failure (in the case of high doses), pregnancy (I trimester), lactation.

    Carefully:Pregnancy (II-III trimesters), renal / hepatic insufficiency.

    Children under 3 years (for this dosage form).

    Pregnancy and lactation:

    During lactation it is recommended to stop breastfeeding.

    Dosing and Administration:

    Inside, during or after a meal, (or squeezed milk), without chewing.

    With trichomoniasis - 250 mg twice a day for 10 days or 400 mg twice a day for 5-8 days.

    Women it is necessary to additionally appoint metronidazole in the form of vaginal suppositories or tablets. If necessary, you can repeat the course of treatment or increase the dose to 0.75-1 g / day. Between the courses should be a break in 3-4 weeks. with the conduct of repeated control laboratory tests.

    An alternative scheme of therapy is the appointment of 2 g once to the patient and his sexual partner.

    Children 3-5 years - 250 mg / day; 5-10 years - 250-375 mg / day, more than 10 years - 500 mg / day.

    The daily dose should be divided into 2 divided doses. The course of treatment is 10 days.

    With giardiasis - 500 mg twice a day for 5-7 days.

    Children from 3 to 5 years old - 250 mg / day, 5-8 years - at 375 mg / day, over 8 years old - 500 mg / day (in 2 divided doses). The course of treatment is 5 days.

    With giardiasis - 15 mg / kg / day in 3 divided doses for 5 days.

    Adults: with asymptomatic amoebiasis (if a cyst is detected), the daily dose is 1-1.5 g (500 mg 2-3 times a day) for 5-7 days.

    With chronic amebiasis daily dose of 1.5 g in 3 divided doses for 5-10 days, with acute amoebic dysentery 2.25 g in 3 doses until symptoms stop.

    With liver abscess the maximum daily dose is 2.5 g in 1 or 2-3 doses, for 3 to 5 days, in combiination with antibiotics (tetracyclines) and other methods of therapy.

    Children 3 years old - 1/4 of the adult dose, 3-7 years - 1/3 of the adult dose, 7-10 years old - 1/2 dose of an adult.

    With balantidiasis - 750 mg 3 times a day for 5-6 days.

    With ulcerative stomatitis adults appoint 500 mg twice a day for 3-5 days; children in this case, the drug is not shown.

    With pseudomembranous colitis - 500 mg 3-4 times a day.

    For eradication Helicobacter pylory - 500 mg 3 times a day for 7 days (as part of combination therapy, for example, combination with amoxicillin 2.25 g / day).

    In the treatment of anaerobic infection the maximum daily vine is 1.5-2 g.

    In the treatment of chronic alcoholism prescribe 500 mg / day for a period of up to 6 (not more) months.

    For the prevention of infectious complications - 750-1500 mg / day in 3 divided doses 3-4 days before surgery, or once 1 g in the first day after the operation. In 1-2 days after the operation (when already allowed ingestion) - 750 mg / day for 7 days.

    With severe renal dysfunction (CC less than 10 ml / min) daily dose should be reduced by half.

    Side effects:

    From the digestive system: diarrhea, anorexia, nausea, vomiting, intestinal colic, constipation, "metallic" taste in the mouth, dry mouth, glossitis, stomatitis, pancreatitis.

    From the nervous system: dizziness, impaired coordination of movements, ataxia, confusion, irritability, depression, increased excitability, weakness, insomnia, headache, convulsions, hallucinations, peripheral neuropathy.

    Allergic reactions: urticaria, skin rash, skin hyperemia, nasal congestion, fever, arthralgia.

    From the genitourinary system: dysuria, cystitis, polyuria, urinary incontinence, candidiasis, staining of urine in red-brown color.

    Other: neutropenia, leukopenia, flattening of the T wave on the electrocardiogram.
    Interaction:

    Strengthens the action indirect anticoagulants, which leads to an increase in the time of prothrombin formation.

    Similarly to disulfiram, causes intolerance ethanol.

    Simultaneous application with disulfiram can lead to the development of various neurological symptoms (the interval between appointment - at least 2 weeks).

    Cimetidine inhibits the metabolism of metronidazole, which can lead to an increase in its concentration in the blood serum and an increased risk of side effects.

    Simultaneous administration of drugs stimulating enzymes of microsomal oxidation in the liver (phenobarbital, phenytoin), can accelerate the elimination of metronidazole, as a result of which its concentration in the plasma decreases.

    With simultaneous reception with drugs lithium may increase the concentration of the latter in the plasma and the development of symptoms of intoxication.

    It is not recommended to combine with nondepolarizing muscle relaxants (vecuronium bromide).

    Sulfonamides enhance the antimicrobial effect of metronidazole.

    Special instructions:

    During the period of treatment, ethanol intake is contraindicated (a disulfiram-like reaction may develop: spastic abdominal pain, nausea, vomiting, headache, sudden rush of blood to the face).

    In combination with amoxicillin it is not recommended to use in patients younger than 18 years.

    With prolonged therapy, it is necessary to monitor the blood picture.

    With leukopenia, the possibility of continuing treatment depends on the risk of developing an infectious process.

    The appearance of ataxia, dizziness and any other worsening of the neurological status of patients requires discontinuation of treatment.

    Can immobilize treponema and lead to Nelson's false positive test.

    Stains urine in a dark color.

    When treating trichomonadal vaginitis in women and trichomoniasis in men, it is necessary to abstain from sexual activity. It is necessary to simultaneously treat sexual partners. Treatment does not stop during menstruation. After trichomoniasis therapy, control tests should be performed for three consecutive cycles before and after menstruation.

    After treatment of giardiasis, if symptoms persist, after 3 to 3 weeks, 3 feces should be analyzed at intervals of several days (in some successfully treated patients, intolerancelactose, caused by invasion, can persist for several weeks or months, recalling the symptoms of giardiasis).

    Effect on the ability to drive transp. cf. and fur:

    In connection with the possibility of dizziness and other side effects associated with taking the drug, it is recommended to refrain from driving and other mechanisms.

    Form release / dosage:

    Tablets, 250 mg.

    Packaging:

    10 tablets in a contour mesh box made of PVC film and aluminum foil.

    1, 2 contour packs together with instructions for use are placed in a pack of cardboard.

    Storage conditions:

    In a dry place, protected from light and out of reach of children, at a temperature not exceeding 25 ° C.

    Shelf life:

    2 years.

    Do not use after the date shown on the package.

    Terms of leave from pharmacies:On prescription
    Registration number:LSR-008819/08
    Date of registration:06.11.2008 / 28.09.2015
    Expiration Date:Unlimited
    The owner of the registration certificate:Promomed Rus, Open CompanyPromomed Rus, Open Company Russia
    Manufacturer: & nbsp
    Information update date: & nbsp18.09.2016
    Illustrated instructions
      Instructions
      Up