Trichobrol - instructions for use, dose, side effects, contraindications

Metronidazole relates to nitro-5-imidazoles and possesses a broad spectrum of activity against anaerobic microorganisms - Peptostreptococcus, Clostridium spp., Vasteroides spp., Fusobacterium, Prevotella, Veillonella. Suppress the development of protozoa - Trichomonas vaginalis, Giardia intestinalis (Lamblia intestinalis), Entamoeba histolytica.

Pharmacokinetics:

Ingestion Metronidazole quickly and almost completely absorbed. Eating does not affect the absorption of the drug. The half-life is 8-10 hours, the connection with blood proteins is insignificant and does not exceed 10-20%. The drug quickly penetrates into tissues (lungs, kidneys, liver, skin), bile, cerebrospinal fluid, saliva, seminal fluid, vaginal secretion, into breast milk and passes through the placental barrier. Metronidazole metabolized by oxidation in the liver and binding to glucuronic acid. Removal of the drug is carried out at 40-70% through the kidneys (in unchanged form - about 20% of the dose) and with feces. In patients with hepatic insufficiency, the half-life period remains unchanged.

Indications:

Trichomonas vaginitis and urethritis in women, trichomoniasis urethritis in men, giardiasis, amoebic dysentery; Anaerobic infections caused by microorganisms that are sensitive to the drug.

Combined therapy of severe mixed aerobic anaerobic infections.

Prevention of anaerobic infection during surgical interventions (especially on the organs of the abdominal cavity, urinary tract).

Chronic alcoholism.

In combination with amoxicillin: chronic gastritis in the exacerbation phase, peptic ulcer of the stomach and duodenum in the acute phase, associated with Helicobacter pylori.

Contraindications:

Hypersensitivity to imidazoles; organic lesions of the central nervous system, impaired liver function; pregnancy and the period of breastfeeding; blood diseases.

Dosing and Administration:

With amebiasis Trichobrol® is administered inside for 7 days to 1.5 g per day in 3 doses (adults) and 0,03-0,04 g / kg per day, as well as in 3 doses (children). With giardiasis, the drug is prescribed for 5 days - adults at 0.75-1.0 g per day, children 2-5 years at 0.25 g per day, children 5-10 years - at 0.375 g per day and children 10-15 years - 0.5 g per day. Take 2-3 times a day after meals.

With trichomoniasis in women (urethritis and vaginitis) Trichobrol® is administered once in a dose of 2 g or as a course of treatment for 10 days: 1 tablet (0.25 g) 2 times a day. In parallel with ingestion appoint in the evening for 1 vaginal suppository or vaginal tablet containing 0.25 g of Trichobrol®.

To exclude possible reinfection, it is necessary to treat simultaneously sexual partners.

The course of treatment is repeated if necessary in 4-6 weeks.

With trichomoniasis in men (urethritis) Trichobrol® is administered once in a dose of 2 g or as a course treatment for 10 days, 1 tablet (0.25 g) 2 times a day.

With nonspecific vaginitis apply 0.5 g of Trichobrol® 2 times a day for 7 days.

In the treatment of anaerobic infections adults are assigned Trichobrol® at 1-1.5 g per day, children - at a rate of 0.02-0.03 g / kg per day.

Side effects:

In rare cases, there is nausea, a metallic taste in the mouth, anorexia, epigastric pain, vomiting, diarrhea, headache, dizziness, as well as local skin reactions such as hives and itching.

Very rarely - convulsions, confusion, hallucinations, depression.

With prolonged treatment with large doses, there may be leukopenia, peripheral neuropathies.

Very rare and reversible cases of pancreatitis are described.

It is possible to stain urine in a brownish-reddish color due to the presence of pigments associated with the metabolism of Trichobrol®.

Interaction:

Pharmacodynamic: Joint oral administration of Trichobrol® with antibiotics-aminoglycosides (neomycin, streptomycin, gentamicin , etc.), erythromycin depresses the pathogenic flora in the digestive tract, which reduces the likelihood of complications after surgery on the colon and rectum.

Under the influence of Trichobrol®, the effects of indirect anticoagulants may be enhanced.

Under the influence of barbiturates, the effect of Trichobrol® can be reduced, as its inactivation in the liver is accelerated.

The spectrum of action of Trichobrol® expands when it is combined with sulfonamides and cephalosporins.

With the combined use of Trichobrol® and ethanol due to the blockade of Trichobrol® in the aldehyde dehydrogenase enzyme, reddening of the face, vomiting, abdominal pain,

Do not combine Trichobrol® with teturam, since the interaction of these drugs may inhibit consciousness, psychotic disorders.

Pharmacokinetic: adsorbents, colestramine, astringent and enveloping agents reduce the absorption of Trichobrol® in the gastrointestinal tract.

Special instructions:

The use of alcoholic beverages during treatment with Trichobrolom® is contraindicated.

Form release / dosage:Tablets, 0.25 g.

Packaging:

For 10, 20, 40, 60 tablets in the package.

Storage conditions:

Keep in a dry place, protected from light and out of the reach of children.

Shelf life:

2 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:P N001388 / 01-2002

Date of registration:15.08.2008

Expiration Date:Unlimited

The owner of the registration certificate:BRYNTSALOV-A, CJSC BRYNTSALOV-A, CJSC Russia

Manufacturer: & nbsp

BRYNTSALOV-A, CJSC Russia

Representation: & nbspBRYNTSALOV-A, CJSCBRYNTSALOV-A, CJSC

Information update date: & nbsp20.09.2016

Illustrated instructions

Instructions

Trichobrol® (Trichobrol®)