Classification of the incidence of adverse events (WHO):
very often> 1/10
often from> 1/100 to <1/10
infrequently from> 1/1000 to <1/100
rarely from> 1/10000 to <1/1000
very rarely from <1/10000, including individual messages.
In each group, unwanted effects are presented in order of decreasing severity.
From the side of the cardiovascular system:
-not often: tachycardia, mild arterial hypertension, unstable blood pressure;
- often: prolongation of the interval QT and tooth;
-very rare: arrhythmia, ventricular tachycardia, fibrillation;
On the part of the hematopoiesis system:
-frequency is not known: leukopenia, agranulocytosis, thrombocytopenia, eosinophilia, pancytopenia;
From the nervous system:
-frequently: extrapyramidal disorders (pseudoparkinsonism, dystonia, akathisia, oculogic crisis, opisthotonus, hyperreflexia), tardive dyskinesia (involuntary movements of the tongue, facial muscles, mouth, lips, trunk and extremities);
-only: headache;
-rarely: malignant neuroleptic syndrome (hyperthermia,
rigidity of muscles, akinesia, lowering of blood pressure, stupor, coma, drowsiness, lethargy);
-frequency is unknown: anxiety, excitement or vivid dreams, depressive states, increased suicidal tendencies;
From the sense organs:
-Often: blurred vision, glaucoma, increased intraocular pressure;
-frequently: turbidity of the lens and cornea;
From the respiratory system:
- often: nasal congestion;
-very rare: bronchial asthma;
From the digestive system:
-No often: nausea, loss of appetite, salivation, dryness of the oral mucosa, constipation, paralytic ileus;
-only: cholestatic jaundice;
From the side of the urinary system:
-non-often: polyuria, bladder paralysis;
- often: nocturnal enuresis, urinary incontinence;
From the skin:
-Often: increased sweating;
-rarely: skin pigmentation, photosensitivity, allergic
dermatitis, urticaria, seborrhea, erythema, eczema, exfoliative dermatitis;
Metabolic and nutritional disorders:
-only: increased appetite, weight gain;
From the side of the reproductive system:
-non-often: gynecomastia, pathological lactation, violations of libido and impotence, irregularities in the regularity of the menstrual cycle, false positive pregnancy test;
- rarely: priapism, ejaculation disorder;
Allergic reactions:
-very rare: edema of the larynx, angioedema;
Other:
There are several reports of sudden, unpredictable and unexplained death among hospitalized patients taking phenothiazines.
With the development of severe adverse effects, treatment should be discontinued.