Frequency of adverse effects: very often (≥ 10%), often (≥ 1%, but <10%), infrequently (≥ 0.1% but <1%), rarely (≥ 0.01%, but <0.1%), very rarely (<0.01%), including individual reports.
Immune system disorders: very rarely - reactions hypersensitivity, including anaphylaxis, angioedema, eosinophilic liver infiltrates.
Violations of the blood and lymphatic system: very rarely - increased bleeding, a tendency to form a hematoma, thrombocytopenia.
Disturbances from the nervous system: often - headache; very rarely - drowsiness, paresthesia / hypoesthesia, convulsions, tremor, dizziness, sleep disturbance, asthenia / fatigue.
Disorders of the psyche: often fatigue; very rarely - excitability, aggressive behavior, anxiety, abnormal dreams, hallucinations, depression, insomnia, irritability, suicidal thinking and behavior, somnambulism.
Heart Disease: very rarely - a feeling of palpitations.
Disorders from the gastrointestinal tract: often - abdominal pain, diarrhea, dyspepsia, nausea; very rarely - vomiting, pancreatitis, dry mouth.
Disturbances from the liver and bile ducts: rarely - cholestatic hepatitis, damage to hepatocytes on the background of drug therapy or concomitant liver pathology (alcohol and other forms of hepatitis), increased activity of "liver" transaminases.
Disturbances of musculoskeletal and connective tissue: very rarely - arthralgia, myalgia, including muscle cramps.
Respiratory system disorders: rarely - pharyngitis, infections of the upper respiratory tract, cough, sinusitis, otitis media (incl.middle), rhinorrhea, flu-like syndrome, epistaxis.
Disturbances from the skin and subcutaneous tissues: often - hives, rash; very rarely - nodular erythema, itching.
General disorders: often - thirst; rarely - malaise, swelling, hyperthermia.
In general, the drug is well tolerated. Side effects are usually mild and, as a rule, do not require withdrawal of treatment.