In general, the drug is well tolerated. Side effects are usually mild and, as a rule, do not require withdrawal of the drug. The overall incidence of side effects with drug treatment is comparable to that of placebo.
Infectious and parasitic diseases: infections of the upper respiratory tract.
On the part of the blood and lymphatic system: increased tendency to bleeding, thrombocytopenia.
From the immune system: hypersensitivity reactions, including anaphylaxis, eosinophilic liver infiltration.
From the nervous system: headache, dizziness, drowsiness, paresthesia / hypesthesia, convulsions.
Disorders of the psyche: pathological dreams, nightmares, hallucinations, insomnia, somnambulism, irritability, anxiety, anxiety, depression, attention and memory disturbances, agitation, including aggressive behavior or hostility, tremor, disorientation, suicidal thoughts and behavior (suicidal).
From the cardiovascular system: cardiopalmus.
On the part of the respiratory system, the organs of the thorax and the mediastinum: nose bleed.
From the gastrointestinal tract: diarrhea, dry mouth, dyspepsia, nausea, vomiting, abdominal pain, pancreatitis.
From the liver and biliary tract: increased activity alanine aminotransferase (ALT) and aspartate aminotransferase (ACT), Hepatitis (including cholestatic, hepatocellular and mixed liver damage).
From the skin and subcutaneous tissues: angioneuroticesky edema, propensity to form hematomas, erythema nodosum, erythema multiforme, itching, urticaria, rashes.
On the part of the organs of the musculoskeletal system and connective tissue: arthralgia, myalgia, including muscle cramps.
General and local disorders: asthenia (weakness) / increased fatigue, swelling, pyrexia, thirst.
Other: In rare cases, patients with bronchial asthma had a development of the Chard-Strauss syndrome (see section "Special instructions").