From the digestive system: rarely - increased appetite, dry mouth, flatulence, aggravation of symptoms of hemorrhoids, erosive and ulcerative lesions of the gastrointestinal tract, abdominal pain, increased activity of "liver enzymes."
From the nervous system and sense organs: more often - unusual fatigue, rarely - blurred vision, confusion, hallucinations, central nervous system depression, ringing and feeling of stuffiness in the ears, pain and burning sensation in the eyes, photophobia, irritability, drowsiness, disorientation in time and space.
From the respiratory system: rarely hoarseness, nasal congestion (hyperemia of the vessels of the nasal cavity), sneezing, shortness of breath, dryness in the throat, increased separation of mucous sputum, sinusitis. From the side of the cardiovascular system: rarely - chest pain, nonspecific ECG changes.
From the genitourinary system: discomfort with urination, increased frequency of urination.
Allergic reactions: less often - skin rash, rarely - hyperthermia, itchy skin, Rarely - increased secretion of sebaceous glands.
Other: rarely - thirst, increase or loss of body weight, pain in the groin, enlargement of lymph nodes, lymphocytosis; in one case, the development of idiopathic thrombocytopenic purpura is described against a background of preliminary sensitization to the drug.
The syndrome of "withdrawal" of opioids: abdominal pain, epigastric cramps, anxiety, nervousness, fatigue, irritability, diarrhea, tachycardia, hyperthermia, rhinorrhea, sneezing, goosebumpia, sweating, yawning, arthralgia, myalgia, anorexia, nausea and / or vomiting, tremor, general weakness.