Side effect
Classification of WHO adverse adverse reactions according to the frequency of development:
Often - > 1/10; often - from 1/100 to 1/10: infrequently - from 1/1000 to 1/100; rarely - from 1/10000 to 1/1000; rarely - <1/10000. including individual messages.
In therapeutic doses in patients with no opioids in their bodies. Naltrexup usually does not cause serious side effects.
From the digestive system: very often - nausea and / or vomiting, abdominal pain; often - abdominal pain, decreased or increased appetite, anorexia, diarrhea or constipation, dryness of the oral mucosa, flatulence, increased activity of "liver" enzymes; rarely - aggravation of hemorrhoid symptoms, erosive and ulcerative lesions of the gastrointestinal tract.
From the nervous system and sense organs: very often - anxiety, nervousness, unusual fatigue, general weakness, restless soybean, "nightmarish" dreams, headache; often - dizziness, blurred vision, confusion, hallucinations, depression of the central nervous system; rarely - depression, delirium,ringing and feeling of stuffiness in the ears, pain and burning sensation in the eyes, photophobia, irritability, drowsiness, disorientation in time and space, migraine, fainting, asthenia, lethargy, lethargy, anxiety.
From the respiratory system: infrequent - cough, hoarseness, nasal congestion (hyperemia of the vessels of the nasal cavity), rheorrhea, sneezing, bronchial obstruction, difficulty breathing, shortness of breath, epistaxis, dryness in the throat, increased mucous sputum, upper respiratory tract infections, sinusitis, laryngitis, pharyngitis including streptococcal), nasopharyngitis, and sinusitis.
From the side of the cardiovascular system: infrequently - chest pain, increased blood pressure, tachycardia, palpitations, nonspecific changes in the electrocardiogram, phlebitis.
From the side of the organs of sight: rarely - konjukuwit.
From the genitourinary system: often - sexual disorders in men delay ejaculation, decreased potency), increased or decreased libido, infrequently - discomfort with urination, increased urination, edematous syndrome (swelling of the face, fingers, feet, shins).
Allergic reactions: often - skin rash, skin hyperemia (including facial hyperemia); hyperthermia, skin itching, increased secretion of sebaceous glands, oznoo.
From the side of the musculoskeletal system: very often - pain in the back, joint stiffness, pain in the extremities, spasm, twitching or stiffness of the muscles; often - arthralgia, myalgia; arthritis, is often unknown - rhabdomyolysis.
From the skin: papular rash, sweating, acne, alopecia.
Other: dry mouth or thirst, sore throat, increased or loss of body weight, pain in the groin, lymphadenopathy, lymphocytosis; oral herpes, foot mycosis; in one case, the development of idiopathic thrombocytopenic purpura is described against a background of preliminary sensation to the drug.
Syndrome of "lifting" opioids: abdominal pain, epigastric spasm, anxiety, nervousness, fatigue, irritability, diarrhea, tachycardia, hyperthermia, rhinorrhea, sneezing, goosebump, sweating, yawning, arthralgia, myalgia, anorexia, nausea and / or vomiting, tremor , general weakness.
If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.
Post-registration application experience
According to the literature, a single case of idiopathic thrombocytopenic purpura is described in a patient who may have been sensitized to naltrexone during the previous treatment. Recovery occurred after the drug was discontinued and a course of corticosteroid therapy was administered.