In therapeutic doses in patients with no opioids in their bodies, Naltrexone usually does not cause serious side effects.
From the digestive system: nausea and / or vomiting, abdominal pain; decreased or increased appetite, anorexia, diarrhea or constipation, dryness of the oral cavity, flatulence, aggravation of hemorrhoid symptoms, erosive and ulcerative lesions of the gastrointestinal tract, abdominal pain, increased activity of "liver" enzymes.
From the nervous system and sense organs: anxiety, nervousness, unusual fatigue, general weakness, restless sleep, nightmarish dreams, headache, dizziness, blurred vision, confusion, hallucinations, central nervous system depression, ringing and feeling of stuffiness in the ears, pain and burning sensation in the eyes , photophobia, irritability, drowsiness, disorientation in time and space, migraine, omborok, asthenia, lethargy, lethargy, anxiety.
From the respiratory system: cough, hoarseness, nasal congestion (hyperemia of the vessels of the nose), rhinorrhea, sneezing, bronchial obstruction, difficulty breathing, shortness of breath, epistaxis, dryness in the throat, increased mucous sputum, upper respiratory tract infections, sinusitis, laryngitis, pharyngitis (v. h.streptococcal), nasopharyngitis.
From the side of the cardiovascular system: chest pain, increased blood pressure, tachycardia, palpitations, nonspecific changes on the electrocardiogram, phlebitis.
From the genitourinary system: discomfort with urination, increased frequency of urination, edematous syndrome (swelling of the face, fingers, feet, shins), sexual disorders in men (delayed ejaculation, decreased potency).
Allergic reactions: skin rash, skin hyperemia (including hyperemia of the face); hyperthermia, skin itching, increased secretion of sebaceous glands, chills.
From the side of the musculoskeletal system: arthralgia, myalgia; arthritis, joint stiffness, back pain, pain in the extremities, spasm, twitching or stiffness of the muscles. From the skin. integument: papular rash, sweating, acne, alopecia.
Other: thirst, increase or loss of body weight, pain in the groin, enlarged lymph nodes, lymphocytosis; the development of idiopathic thrombocytopenic purpura on the background of preliminary sensitization to the drug (recovery occurred after discontinuation of the drug and the course of glucocorticosteroid therapy).
Opioid withdrawal syndrome: abdominal pain, spasm in the epigastric region, anxiety, nervousness, fatigue, irritability, diarrhea, tachycardia, hyperthermia, rhinorrhea, sneezing, goosebumpiness, sweating, yawning, arthralgia, myalgia, anorexia, nausea and / or vomiting, tremor, total weakness.
Post-marketing experience:
From the digestive system: perversion of taste, gastroesophageal reflux disease, hemorrhoids, colitis, gastrointestinal bleeding, paralytic, intestinal obstruction, pararectal abscess, gastroenteritis, tooth abscess, cholelithiasis, acute cholecystitis.
From the central nervous system: violation of concentration, convulsions, ischemic stroke, aneurysm of the cerebral arteries, irritability, alcohol withdrawal syndrome, agitation, euphoria, delirium.
From the side of the musculoskeletal system: pain in the extremities.
From the skin: inflammation of the subcutaneous tissue.
From the sense organs: conjunctivitis.
From the respiratory system: sore throat, shortness of breath, chronic obstructive pulmonary disease, influenza, bronchitis, pneumonia.
Co cardiovascular system: "hot flashes", deep vein thrombosis, pulmonary embolism, fibrillation, atrial, myocardial infarction, angina, incl. unstable, chronic heart failure, coronary artery atherosclerosis.
Other: heat stroke, dehydration, hypercholesterolemia, leukocytosis. Allergic reactions: angioedema, urticaria.
From the urinary system: urinary tract infections.
On the part of the reproductive system: spontaneous abortion, decreased libido.