Oxycourt® (Oxycort®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceHydrocortisone + OxytetracyclineHydrocortisone + Oxytetracycline
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    • Dosage form: & nbsp

    ointment for external use

    Composition:

    In 1 g of ointment:

    Active substances: hydrocortisone acetate 10.0 mg, oxytetracycline 30.0 mg, (in the form of oxytetracycline hydrochloride)

    Excipient: Vaseline - up to 1.0 g

    Description:

    Homogeneous yellow ointment.

    Pharmacotherapeutic group:Antimicrobial agent + glucocorticosteroid for topical application
    ATX: & nbsp

    D.07.C.A.01   Hydrocortisone in combination with antibiotics

    Pharmacodynamics:

    Oxycort ® is a combined preparation, the effect of which is due to the components that make up its composition. As a result of the combined effect of hydrocortisone and oxytetracycline, the drug suppresses the development of inflammatory-allergic skin reactions complicated by bacterial infection.

    Oxytetracycline: an antibiotic from the group of tetracyclines.It has a bacteriostatic effect by inhibiting translation during protein synthesis in microbial cells. Has a wide spectrum of action, is active against Gram-positive (Staphylococcus spp., including those producing penicillinase, Streptococcus spp., in t.ch. Streptococcus pneumoniae, Clostridium spp., Bacillus anthracis, Listeria monocytogenes) and gram-negative (Neisseria gonorrhoeae, Bordetella pertussis, Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp.) microorganisms, and Rickettsia spp., Chlamydiaceae, Mycoplasma spp., Actinomyces spp., Mycobacterium spp., Spirochaetaceae. Hydrocortisone is a synthetic glucocorticosteroid drug for external use. Has anti-inflammatory, anti-edematous, antipruritic effect. Inhibits the release of cytokines (interleukins and interferon) from lymphocytes and macrophages, eosinophils inhibits the release of inflammatory mediators, arachidonic acid gives metabolism and prostaglandin synthesis., Stimulating glucocorticoid receptors induces the formation of lipocortin. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes, incl. lymphocytes into the area of ​​inflammation. When administered at recommended doses does not cause systemic side effects.
    Pharmacokinetics:

    After applying Oksikort® ointment on the skin, the active components accumulate in the epidermis (mainly in the granular layer).

    Oxytetracycline, when applied externally to the skin, is not practically absorbed and does not have a systemic effect, a small amount of it after resorption undergoes biotransformation in the liver and is excreted by the kidneys.

    Hydrocortisone after application accumulates in the epidermis (mainly in the granular layer). Metabolized directly in the epidermis, and later in the liver. It is excreted by the kidneys and intestines.

    Indications:

    Diseases of the skin complicated by a secondary bacterial infection caused by the microflora-sensitive oxytetracycline:

    - dermatitis allergic,

    - contact dermatitis,

    - professional dermatitis,

    - seborrheic dermatitis,

    - sunny dermatitis,

    - atopic dermatitis,

    - scrapes,

    - eczema,

    - multiform erythema exudative,

    - psoriasis,

    - burns I-II degree,

    - frostbite.

    Contraindications:

    Hypersensitivity to the components of the drug. Viral skin diseases, tuberculosis, syphilis, dermatomycosis, neoplasms and precancerous skin diseases, rosacea and perioral dermatitis, skin reactions after vaccination, pregnancy and lactation period; children's age up to 2 years.

    Carefully:Not described.
    Pregnancy and lactation:Contraindicated.
    Dosing and Administration:

    Outwardly. Ointment is applied a thin layer on the affected skin 2-3 times a day; it is possible to use an occlusive dressing. The course of treatment is 1-2 weeks.

    When using the drug on the face, avoid applying it to the periorbital area.

    Children are used in limited areas of the skin for a short course (for 5-7 days).

    Side effects:

    When the drug is used, itching, rash and skin irritation are possible. With prolonged use, the appearance of acne, telangiectasias, striae, atrophy of the skin.

    Overdose:

    Overdose is very rare. However, with long-term use of drugs containing glucocorticosteroids for external use, the suppression of adrenal cortex function with the development of secondary adrenal insufficiency and symptoms of hypercorticism, including Itenko-Cushing syndrome, is possible on a vast surface.

    Overdose of oxytetracycline can lead to an increase in insensitive microflora.

    Treatment: symptomatic. Acute symptoms of hypercorticoidism are usually reversible. If necessary, correct the electrolyte balance.

    Interaction:

    With external use of the drug, interactions with other drugs have not been identified.

    Special instructions:

    Do not exceed the course of treatment. Do not use for a long time on extensive skin areas. Avoid getting ointment in the eyes. If it is necessary to apply the drug to the skin of the face and skin folds, the treatment should be short (within 5-7 days).

    Effect on the ability to drive transp. cf. and fur:

    The drug does not limit the psychophysical ability, the ability to drive vehicles and maintain machinery in motion.

    Form release / dosage:

    Ointment for external use 10 mg + 30 mg / g.

    Packaging:

    10 grams in aluminum, inside lacquered lithographed tubes.

    The tube with the instructions for use is placed in a lithographed cardboard box.

    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:

    2 years. Do not use after expiry date.

    Terms of leave from pharmacies:On prescription
    Registration number:П N014899 / 01
    Date of registration:29.05.2009
    Expiration Date:Unlimited
    Date of cancellation:2017-11-14
    The owner of the registration certificate:VALEANT, LLC VALEANT, LLC Russia
    Manufacturer: & nbsp
    Representation: & nbspVALEANT LLC VALEANT LLC Russia
    Information update date: & nbsp14.11.2017
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