Pefloxabol® is a synthetic antimicrobial agent from the group of monofluoroquinolones.It acts bactericidal, inhibiting the DNA-gyrase enzyme and the replication of bacterial DNA; also disrupts the replication of the A-subunit of ribonucleic acid and the synthesis of proteins by a bacterial cell. Causes the death of gram-negative bacteria both in the fission phase and in the resting phase. The bactericidal effect against Gram-positive bacteria extends only to cells in process mitotic division. Characteristic postantibiotic effect.
Pefloxabol ® has a broad spectrum of antimicrobial activity. It is active against gram-positive cocci: Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus (activity in relation to Streptococcus spp., including S. pneumoniae, Enterococcus spp., low and clinically insignificant); Gram-negative cocci and bacteria: Acinetobacter spp. (moderately sensitive), Aeromonas spp., Campylobacter spp., Citrobacter spp., Enterobacter spp., Escherichia coli, Gardnerella vaginalis (moderately sensitive), Haemophilus ducreyi, Haemophilus influenzae, Klebsiella spp., Moraxella catarrhalis, Morganella spp., Neisseria gonorrhoeae, Neisseria meningitidis, Pasteurella multocida, Proteus mirabilis, Proteus vulgaris, Providencia spp., Pseudomonas aeruginosa, Salmonella spp., Serratia spp., Shigella spp., Vibrio spp., Yersinia spp .; obligate intracellular parasites: Chlamydia spp., Chlamydophila pneumoniae, Legionella spp., Mycoplasma spp. (moderately sensitive).
He is destroyed by beta-lactamases, acts on many strains resistant to penicillins, cephalosporins and aminoglycosides.
Insensitive to Pefloxabol®: strains Staphylococcus spp., resistant to methicillin, Listeria spp., gram-negative anaerobes (Bacteroides fragilis, Bacteroides spp., Prevotella spp., Fusobacterium spp.), Clostridium spp., Treponema spp., Mycobacterium tuberculosis.