Pentalgin®-ICN (Pentalgin®-ICN)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Dosage form: & nbsppills
Composition:

Active substances: metamizole sodium - 300 mg, paracetamol - 300 mg, caffeine (in neon a dry matter basis) - 50 mg, codeine phosphate (in terms of dry matter) - 8 mg, phenobarbital-10 mg;

Excipients: starch of cardboardfelted - 120 mg, povidone (polyvinylpyrlow molecular weight medical rolidon) - 4 mg, stearic acid - 4 mg, calcium stearate - 4 mg.

Description:

Tablets from white to white with a yellow or cream shade of color, biconvex in the form of capsules with flat lateral surfaces, with a risk on one side and engraving PENTALGIN another.

Pharmacotherapeutic group:Analgesic agent (analgesic opioid + NSAID + analgesic non-narcotic + psychostimulating drug + barbiturate)
ATX: & nbsp
  • Metamizole sodium in combination with psycholeptics
    • Pharmacodynamics:

    Combined drug, has analgesic, antipyretic, antimigraine action.

    Paracetamol is a non-narcotic analgesic; blocks cyclooxygenase mainly in the central nervous system, affecting the centers of pain and thermoregulation; has analgesic and antipyretic effect. Metamizol sodium - a non-steroidal anti-inflammatory agent with a pronounced analgesic effect. Caffeine improves the health of patients and reduces the headache of vascular genesis (including migraine). Phenobarbital increases the analgesic effectiveness of metamizole sodium and paracetamol. Codeine has an analgesic effect due to the excitation of opiate receptors in various parts of the central nervous system, leading to stimulation of the antinocep- tive system and a change in the emotional perception of pain.

    Pharmacokinetics:

    Indications:"Pentalgin®-INC" is used for pain syndrome of various genesis of mild and moderate intensity (including pain in joints, muscles, radiculitis, menstrual pains, neuralgia, headache and dental pain).

    "Pentalgin®-INC"can be used for catarrhal conditions accompanied by febrile syndrome.

    Contraindications:

    Hypersensitivity, severe hepatic and / or renal insufficiency, bronchial asthma, deficiency of glucose-6-phosphate dehydrogenase; anemia, leukopenia; conditions accompanied by respiratory depression; craniocerebral hypertension, acute myocardial infarction; arrhythmias, alcoholic intoxication, glaucoma, pregnancy, lactation period, children's age (up to 12 years).

    Carefully:Stomach ulcer and duodenal ulcer (in remission), elderly age, arterial hypertension.
    Pregnancy and lactation:Contraindicated.
    Dosing and Administration:The drug is usually taken 1 tablet 1-3 times a day. The maximum daily dose is 4 tablets. The drug should not be taken more than 5 days as an anesthetic and more than 3 days as antipyretic agent without prescription and supervision by a physician.
    Side effects:

    Allergic reactions (rash, itching, urticaria), dizziness, drowsiness, palpitation, tachycardia, nausea, vomiting, constipation; leukopenia, granulocytopenia, agranulocytosis. With prolonged uncontrolled admission in high doses - addiction (weakening of the analgesic effect), drug dependence (codeine); hepatic and / or renal failure.

    Overdose:Nausea, vomiting, gastralgia, tachycardia, arrhythmia, oppression of the respiratory center. It shows gastric lavage, the appointment of intestinal adsorbents, if necessary, symptomatic therapy.
    Interaction:

    With the simultaneous use of funds that exert a depressing effect on the central nervous system (incl.sedatives and tranquilizers) is likely to increase the severity of sedation and depressant effect on the respiratory center.

    Increases the effect of ethanol on the psychomotor response.

    Metamizole sodium reduces the concentration of cyclosporine.

    Metamizole sodium, displacing from the bond with protein oral hypoglycemic drugs, indirect anticoagulants, glucocorticosteroids and indomethacin, increases their activity. Tricyclic antidepressants, oral contraceptives, allopurinol disrupt metamizole metabolism in the liver and increase its toxicity.

    Simultaneous use of the drug with other non-narcotic analgesics may lead to an increase in toxic effects.

    Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole.

    Special instructions:

    With prolonged (more than 1 week) treatment need control of the picture peripherallyblood and functional state liver. Can change test results qping-control athletes. It is difficult to establish a diagnosis with acute abdominal pain syndrome. In patients with atopic bronchitischaly asthma, pollinosis, there is aincreased risk of hypersensitivity reactionsviability.

    Effect on the ability to drive transp. cf. and fur:

    In connection with the possibility of developing sedative action, during the treatment it is not recommended to drive vehicles and engage in other potentially hazardous activities requiring increased concentration of attention, speed of psychomotor and motor reactions.

    Form release / dosage:Pills.
    Packaging:

    For 6, 10 or 12 tablets in a planar cell package.

    1 or 2 contour mesh packages together with instructions for use in a pack of cardboard.

    Storage conditions:

    Store at a temperature not exceeding 25 ° C.

    Keep out of the reach of children.

    Shelf life:3 years. Do not use at the end of the expiration date indicated on the packing.
    Terms of leave from pharmacies:Without recipe
    Registration number:P N000343 / 01
    Date of registration:02.07.2010 / 26.05.2015
    The owner of the registration certificate:PHARMSTANDART-FORESTRY, OJSC PHARMSTANDART-FORESTRY, OJSC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp11.02.2016
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