Most often when taking pentoksifillina may appear undesirable phenomena from the gastrointestinal tract (nausea, a feeling of overflow in the abdomen, stomach cramps, vomiting, diarrhea). Sometimes dizziness and headache may occur.
Occasionally one can observe lowering of arterial pressure, angina pectoris, disturbance of heart rhythm, sensation of tidal flow.
In rare cases, reactions of increased sensitivity observed redness of the skin, itching, hives.
In some cases, jaundice (intrahepatic cholestasis) and elevated liver enzymes (transaminase, alkaline phosphatase) may appear. In isolated cases, the emergence of very severe hypersensitivity reactions - angioedema, developing within a few minutes after taking pentoxifylline, convulsive spasm of the muscles of the bronchi, anaphylactic shock.
At the first sign of a hypersensitivity reaction, it is necessary to stop taking the drug and consult a doctor immediately.
There are separate reports on the possibility of bleeding (in the gastrointestinal tract, in the skin, in the mucous membranes), thrombocytopenia and aplastic anemia. Therefore, in the treatment of pentoxifylline, regular monitoring of the blood picture is necessary.