The most common adverse effects of pentoxifylline are gastrointestinal (nausea, a feeling of overflow in the abdomen, stomach spasms, vomiting, diarrhea). Sometimes dizziness and headache may occur. Occasionally one can observe lowering of arterial pressure, angina pectoris, disturbance of heart rhythm, sensation of tidal flow.
In rare cases of hypersensitivity reactions, reddening of the skin, itching, urticaria were observed.
In some cases, jaundice (intrahepatic cholestasis) and elevated liver enzymes (transaminase, alkaline phosphatase) may appear.
In isolated cases, the emergence of very severe hypersensitivity reactions - angioedema, developing within a few minutes after taking Pentoxifylline, convulsive spasm of the muscles of the bronchi, anaphylactic shock.
At the first sign of a hypersensitivity reaction, it is necessary to stop taking the drug and consult a doctor immediately.
There are separate reports on the possibility of bleeding (in the gastrointestinal tract, in the skin, in the mucous membranes), thrombocytopenia and aplastic anemia. In this regard, the treatment with Pentoxifylline requires regular monitoring of the blood picture.