The frequency of possible side effects listed below is determined as follows: very often (≥ 1/10); often (≥ 1/100 to <1/10); infrequently (≥ 1/1000 to <1/100); rarely (≥ 1/10000 to <1/1000); very rarely (<1/10000); frequency is unknown (can not be estimated from available data).
Violations of the blood and lymphatic system:
Very rarely: thrombocytopenia, thrombocytopenic purpura, aplastic anemia, pancytopenia.
Rarely: bleeding (including nosebleeds, gastrointestinal bleeding, bleeding from the urinary tract, etc.).
Immune system disorders:
Infrequent: hypersensitivity reactions.
Very rarely: heavy,occurring within a few minutes after the administration of pentoxifylline anaphylactic or anaphylactoid reactions, Quincke's edema, bronchospasm, anaphylactic shock.
Disorders of the psyche:
Infrequent: increased excitability, insomnia.
Disturbances from the nervous system:
Infrequent: dizziness, tremor, headache.
Very rarely: paresthesia, convulsions, intracranial hemorrhage, aseptic meningitis.
Disturbances on the part of the organ of sight:
Infrequent: impaired vision, conjunctivitis.
Very rarely: hemorrhage into the retina of the eye, detachment of the retina of the eye.
Heart Disease:
Infrequent: a violation of the rhythm of the heart, tachycardia.
Rarely: stenocardia, dyspnea.
Vascular disorders:
Often: hyperemia of the skin of the face.
Rarely: lowering blood pressure, peripheral edema.
Very rarely: increased blood pressure.
Disorders from the gastrointestinal tract:
Often: nausea, vomiting, bloating, a feeling of heaviness in the stomach, diarrhea.
Disturbances from the liver and bile ducts:
Very rarely: intrahepatic cholestasis, increased activity of "liver" transaminases.
Disturbances from the skin and subcutaneous tissues:
Infrequent: itchy skin, erythema, urticaria.
Very rarely: toxic epidermal necrolysis, Stevens-Johnson syndrome, increased sweating.
General disorders and disorders at the site of administration:
Infrequent: increased body temperature.