Potassium chloride + Calcium chloride + Magnesium chloride + Sodium lactate + Sodium chloride + Sorbitol (Kalii chloridum + Calcii chloridum + Magnii chloridum + Natrii lactas + Natrii chloridum + Sorbitolum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Substitutes for plasma and other blood components

Included in the formulation
  • Rheosorbylact®
    solution in / in d / infusion 
    YURIYA-FARM, LLC     Ukraine
  • Ringer's lactate with magnesium
    solution in / in d / infusion 
    FIRM MEDPOLIMER, JSC     Russia
  • Sorbylact®
    solution d / infusion in / in 
    YURIYA-FARM, LLC     Ukraine
    • АТХ:

    B.05.X.A.31   Electrolytes in combination with other drugs

    Pharmacodynamics:

    Pharmacological effects are associated mainly with sorbitol and sodium lactate. Isotonic sorbitol solution has a disaggregant effect, which improves microcirculation of tissues. Sodium lactate reduces fluctuations in metabolic acidosis, is slowly included in the metabolism, as a result of which there are no abrupt changes pH. The action begins in 20-30 minutes after administration. Sodium chloride replenishes deficiency of ions of chlorine and sodium at various pathological processes. Clinically manifested in the form of detoxification and rehydration effects. Calcium chloride replenishes deficiency of calcium ions. Influences on the decrease in the permeability of cells and the vascular wall, reduces the development of inflammatory reactions, significantly enhances phagocytosis. Potassium chloride normalizes the water-electrolyte balance. It shows a negative chrono and batmotroponoe action in high doses - a negative foreign-, dromotropic and mild diuretic effect.

    Pharmacokinetics:

    Sorbitol: Absorption is low. Biotransformation in the liver to fructose (enzyme sorbitol dehydrogenase) and glucose (enzyme aldose reductase). Sodium lactate in the vascular bed interacts with carbon dioxide and water, resulting in the formation of sodium bicarbonate, which increases the alkaline reserve of blood. Only isomer is metabolized L sodium lactate, isomer D is not active and is excreted by the kidneys. Sodium chloride temporarily increases the volume of circulating blood and is quickly eliminated from the vascular bed.

    Indications:

    - with the aim of prevention and treatment of traumatic, operating, hemolytic, toxic and burn shock, with acute blood loss, burn disease;

    - conditions accompanied by intoxication, exacerbation of chronic hepatitis, infectious diseases;

    - sepsis;

    - with the purpose of preoperative preparation and in the postoperative period;

    - to improve arterial and venous circulation for the prevention and treatment of thrombosis, thrombophlebitis, endarteritis;

    Raynaud's disease.

    ICD-10

    I.A30-A49.A41.9   Septicemia, unspecified

    I.A30-A49.A48.3   Toxic shock syndrome

    I.B99.B99   Other and unspecified infectious diseases

    IX.I70-I79.I73.0   Raynaud's syndrome

    IX.I70-I79.I73.8   Other specified diseases of peripheral vessels

    IX.I80-I89.I80.9   Phlebitis and thrombophlebitis of unspecified site

    IX.I80-I89.I82.9   Embolism and thrombosis of unspecified vein

    XVIII.R50-R69.R57.8   Other types of shock

    XVIII.R50-R69.R57.9   Shock, unspecified

    XIX.T20-T32   Thermal and chemical burns

    XXI.Z80-Z99.Z98.8   Other specified post-surgical conditions

    Contraindications:

    - alkalosis;

    - in cases where the infusion of large amounts of fluid is contraindicated (cerebral hemorrhage, thromboembolism, cardiovascular decompensation, arterial hypertension of the third degree);

    - Hypersensitivity to the components of the drug.

    Carefully:

    It is necessary to prescribe the drug to patients with impaired liver function, peptic ulcer, hemorrhagic colitis.

    Pregnancy and lactation:

    Adequate and well-controlled studies in humans and animals have not been conducted. There is no information on the penetration into breast milk. It is a part of breast milk.

    Action category for the fetus by FDA - AT.

    Dosing and Administration:

    Adults intravenously stream or drip.

    In case of traumatic, burn, postoperative and hemolytic shock - 600-1000 ml (10-15 ml / kg body weight) once and repeatedly, first spray, then - drip.

    In chronic hepatitis - 400 ml (6-7 ml / kg body weight) drip, repeatedly.

    In acute blood loss - 1500-1800 ml (up to 25 ml / kg of body weight).

    In the preoperative period and after various surgical interventions - in a dose of 400 ml (6-7 ml / kg body weight) drip, once or repeatedly, daily, for 3-5 days.

    In case of thromboobliterating diseases of blood vessels - at the rate of 8-10 ml / kg of body weight, drip, repeatedly, every other day. The course of treatment - up to 10 infusions.

    Children under the age of 6 years are recommended to administer the drug in a dose of 10 ml / kg of body weight; at the age of 6 to 12 years - at a dose of half the dose for adults; children over 12 years of age, the dose of the drug is the same as for adults.

    Side effects:

    Perhaps the development of alkalosis, allergic reactions (rashes on the skin, itching).

    Overdose:

    Symptoms: phenomena of alkalosis (quickly pass independently, provided that the drug is immediately stopped).

    Interaction:

    Do not mix with phosphate- and carbonate-containing solutions. Do not use as a carrier solution for other drugs.

    Special instructions:

    The drug is used under the control of acid-base state and blood electrolytes, as well as the functional state of the liver. With caution apply in patients suffering from calculous cholecystitis.

    Instructions
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