Rheosorbylact® (Rheosorbilact)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePotassium chloride + Calcium chloride + Magnesium chloride + Sodium lactate + Sodium chloride + SorbitolPotassium chloride + Calcium chloride + Magnesium chloride + Sodium lactate + Sodium chloride + Sorbitol
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  • Rheosorbylact®
    solution in / in d / infusion 
    YURIYA-FARM, LLC     Ukraine
  • Ringer's lactate with magnesium
    solution in / in d / infusion 
    FIRM MEDPOLIMER, JSC     Russia
  • Sorbylact®
    solution d / infusion in / in 
    YURIYA-FARM, LLC     Ukraine
    • Dosage form: & nbspsolution for infusions
    Composition:

    In 1 ml of solution contains:

    Active substances: sorbitol - 60.00 mg, sodium lactate - 19.00 mg, sodium chloride - 6.00 mg, calcium chloride in terms of dry matter - 0.1 mg, potassium chloride - 0.3 mg, magnesium chloride in terms of dry substance - 0.2 mg; Excipients: water for injection - up to 1 ml.

    Ionic composition of the preparation:

    in mg / ml

    in mmol / l

    Na+

    6,395

    278,16

    TO+

    0,157

    4,02

    Ca++

    0,036

    0,90

    Mg++

    0,051

    2,10

    cg

    3,995

    112,69

    CH3CH (OH) COO

    15,635

    175,52
    Theoretical osmolality 900 mOsm / l

    Description:clear colorless liquid
    Pharmacotherapeutic group:plasma-substituting agent
    ATX: & nbsp

    B.05.X.A.31   Electrolytes in combination with other drugs

    Pharmacodynamics:

    Pharmacodynamics. Rheosorbylact® has rheological, anti-shocks, detoxification, alkalizing action. The main pharmacologically active substances are sorbitol and sodium lactate. In the liver sorbitol first turns into fructose, which then turns into glucose, and then into glycogen.Part of sorbitol is used for urgent energy needs, the other part is stored as a stock in the form of glycogen. Isotonic sorbitol solution has a disaggregant effect and, thus, improves microcirculation and perfusion of tissues.

    Unlike the bicarbonate solution, correction of metabolic acidosis with sodium lactate passes more slowly as it enters the metabolism, without causing sharp fluctuations in pH. The effect of sodium lactate is manifested after 20-30 minutes after administration.

    Sodium chloride - plazmozameschayuschee means, shows detoxication, rehydration effect. Eliminates deficiency of sodium and chlorine ions at various pathological conditions.

    Calcium chloride eliminates calcium deficiency. Calcium ions are necessary for the process of transmission of nerve impulses, reduction of skeletal and smooth muscles, myocardial activity, bone formation, and blood clotting. Reduces the permeability of cells and the vascular wall, prevents the development of inflammatory reactions, increases the resistance of the body to infections and can significantly enhance phagocytosis.

    Potassium chloride restores the water-electrolyte balance.It shows a negative chrono and batmotroponoe action in high doses - a negative foreign-, dromotropic and mild diuretic effect. Takes part in the process of carrying out nervous impulses. Increases the content of acetylcholine and causes excitation of the sympathetic part of the autonomic nervous system. Improves the contraction of skeletal muscles in muscular dystrophy, myasthenia gravis.

    Pharmacokinetics:

    Sorbitol quickly included in the overall metabolism of 80-90% of which is utilized in the liver and accumulate in the form of glycogen, 5% is deposited in the brain tissue, cardiac muscle and skeletal muscle, 6-12% excreted in urine. With the introduction of sodium lactate into the vascular bed, sodium, CO2 and H2O, which form sodium bicarbonate, which leads to an increase in the alkaline reserve of blood. Only half of the sodium lactate injected is considered active (isomer L), and the other half (isomer D) It is not metabolized and excreted in the urine.

    Sodium chloride is rapidly excreted from the vascular bed, only temporarily increasing the volume of circulating blood. Do diuresis.

    Indications:

    Reosorbilakt® used to improve the capillary blood flow in the prevention and treatment of traumatic,operational, hemolytic, toxic and burn shock, with acute blood loss, burn disease; infectious diseases, accompanied by intoxication, exacerbation of chronic hepatitis; sepsis, for preoperative preparation and in the postoperative period, to improve arterial and venous circulation for the prevention and treatment of thrombosis, thrombophlebitis, endarteritis, Raynaud's disease.

    Contraindications:

    Individual intolerance to the components of the drug. Rheosorbylact® is not administered in alkalosis, and in cases where large amounts of fluid are contraindicated (cerebral hemorrhage, thromboembolism, cardiovascular decompensation, arterial hypertension, schizophrenic disease).

    Carefully:Carefully the drug is prescribed to patients with impaired liver function, peptic ulcer, hemorrhagic colitis.
    Pregnancy and lactation:

    Data on use during pregnancy and breastfeeding are not available.

    Dosing and Administration:

    Rheosorbylact® is administered to adults intravenously in a stream or drip:

    - In case of traumatic, burn, postoperative and hemolytic shocks, 600-1000 ml (10-15 ml / kg body weight of the patient) once and repeatedly, first by jet, then by drop method;

    - with chronic hepatitis - 400 ml (6-7 ml / kg body weight) drip, repeatedly;

    - with acute blood loss - 1500-1800 ml (up to 25 ml / kg of body weight). In this case, the infusion of Rheosorbilact® is recommended to be performed at the pre-hospital stage, in a specialized ambulance;

    - in the preoperative period and after various surgical interventions - in a dose of 400 ml (6-7 ml / kg body weight) drip, once or repeatedly, daily, for 3-5 days;

    - with thromboembolitating diseases of blood vessels - at the rate of 8-10 ml / kg of body weight, drip, repeatedly, every other day, up to 10 infusions per course of treatment.

    Children under the age of 6 years are recommended to administer the drug at a dose of 10 ml / kg of body weight, from 6 to 12 years - in a dose of half the dose for adults. Children over 12 years of age are given the same dose as adults.

    Side effects:

    There may be phenomena of alkalosis, allergic reactions (rashes on the skin, itching).

    Overdose:There are phenomena of alkalosis, which quickly pass on their own, provided that the drug is discontinued immediately.
    Interaction:

    Rheosorbylact® should not be mixed with phosphate- and carbonate-containing solutions.Do not use as a carrier solution for other medications.

    Special instructions:

    The drug is used under the control of acid-base state and blood electrolytes, as well as the functional state of the liver. With caution apply to patients suffering from calculous cholecystitis.

    Effect on the ability to drive transp. cf. and fur:not described
    Form release / dosage:

    Solution for infusion. For 200 or 400 ml of the drug in glass bottles. Each bottle together with the instruction for use is put in a pack of cardboard.

    Packaging:bottles (1) -tacks, cardboard
    vials (16) -shaped shrink film
    bottles (30) -shaped shrink film
    vials (32) -wrapping paper
    bottles (32) - cardboard packing
    vials (60) -wrapping paper
    bottles (60) - cardboard packing
    Storage conditions:

    List B. In a dry, the dark place at a temperature of 2 to 25 ° C.

    Shelf life:2 years. Do not use after expiry date.
    Terms of leave from pharmacies:On prescription
    Registration number:LSR-003845/08
    Date of registration:19.05.2008
    The owner of the registration certificate:YURIYA-FARM, LLC YURIYA-FARM, LLC Ukraine
    Manufacturer: & nbsp
    Representation: & nbspYURIYA-FARM LLC YURIYA-FARM LLC Ukraine
    Information update date: & nbsp11.09.2014
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