Caffeine + Paracetamol + Propyphenazone (Coffeinum + Paracetamolum + Propyphenazonum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Anilides

Included in the formulation
  • Kaffetin® ck
    pills inwards 
    Alkaloid, JSC     Macedonia
  • Новалгин
    pills inwards 
    ALVILS Patent, Open Company    
  • Saridon®
    pills inwards 
    BAYER, AO     Russia
  • Safiston
    pills inwards 
    ATOLL, LLC     Russia
  • Flukomp Extract
    pills inwards 
    OBOLENSKOE PHARMACEUTICAL ENTERPRISE, CJSC     Russia
    • АТХ:

    N.02.B.E   Anilides

    Pharmacodynamics:

    Combined drug, thanks to the composition of a number of actions. Caffeine shows an analeptic and psycho-stimulating effect, removes drowsiness and fatigue, increases the effect of analgesics and increases physical and mental performance. Paracetamol and propiphenazone have an analgesic and antipyretic effect.

    Pharmacokinetics:

    Caffeine binds to plasma proteins by 25-36%. Biotransformation in the liver, in adults 80% of caffeine is metabolized to paraxanthin (1,7-dimethylxanthine), 10% to theobromine (3,7-dimethylxanthine) and 4% to theophylline (1,3-dimethylxanthine), the compounds are demethylated in monomethylxanthines, and then into methylated derivatives of uric acid. Preterm infants theophylline turns into caffeine. The half-life is 3-7 hours, in newborns - 65-130 hours, decrease to the level of adults in 4-7 months. Maximum concentration through 50-75 minutes.It is excreted by the kidneys (in the form of metabolites, 1-2% unchanged), in newborns by the kidneys (85% unchanged).

    Absorption of paracetamol is fast and complete. Linkage to plasma proteins is clinically insignificant. Biotransformation in the liver (CYP2E1). Intermediate metabolites are cumulated overdose, hepatotoxic. Half-life ~ 1-4 hours. Displayed kidneys in the form of conjugates, 3% - unchanged.

    Indications:

    Pain syndrome of moderate severity: headache, toothache, myalgia, post-traumatic pain.

    Feverish syndrome.

    "Catarrhal" diseases, influenza.

    ICD-10

    VI.G40-G47.G43   Migraine

    XIII.M20-M25.M25.5   Pain in the joint

    XIII.M70-M79.M79.1   Myalgia

    XIII.M70-M79.M79.2   Neuralgia and neuritis, unspecified

    XIV.N80-N98.N94.6   Dysmenorrhea, unspecified

    XVIII.R50-R69.R52.9   Pain, unspecified

    XVIII.R50-R69.R52.2   Another constant pain

    XVIII.R50-R69.R51   Headache

    XIX.T08-T14.T14.9   Injury, unspecified

    Contraindications:

    Individual intolerance.

    Severe hepatic and / or renal failure.

    Deficiency of glucose-6-phosphate dehydrogenase.

    Oppression of bone marrow hematopoiesis (leukopenia, anemia, including hemolytic).

    Acute hematoporphyria.

    Bronchial asthma.

    Conditions accompanied by respiratory depression.

    Intracranial hypertension.

    Acute myocardial infarction, arrhythmias, arterial hypertension.

    Alcoholic intoxication and alcoholism.

    Glaucoma.

    Pregnancy and breastfeeding.

    Children under 12 years.

    Carefully:

    Peptic ulcer of stomach and duodenum in acute stage.

    Elderly age.

    Pregnancy and lactation:

    Recommendations FDA category C. It is undesirable to use the drug during pregnancy and during breastfeeding.

    Dosing and Administration:

    The drug is taken internally 1 tablet up to 4 times a day, with a small amount of water.

    Side effects:

    Digestive system: nausea.

    The cardiovascular system: rise blood pressure.

    Nervous system: insomnia.

    Allergic reactions: redness of the skin, skin rash, bronchospasm, runny nose.

    Overdose:

    When an overdose is observed visual impairment, arrhythmia, vomiting, abdominal pain, icterus of the skin, convulsions, increased excitability, drowsiness, loss of consciousness.

    For treatment, it is necessary to introduce donors of SH-groups and precursors of glutathione-methionine synthesis 8-9 hours after an overdose and N-acetylcysteine ​​after 12 hours.To prevent liver damage, gastric lavage is performed.

    Interaction:

    With long-term admission paracetamol can enhance the effect of anticoagulants (derivatives of dicumarin).

    Strengthens the action of inhibitors MAO.

    Reduces the effectiveness of uricosuric preparations.

    Caffeine accelerates the absorption of ergotamine.

    With simultaneous use paracetamol increases the time taken to withdraw chloramphenicol 5 times.

    The use of paracetamol and ethanol simultaneously increases the probability of development of hepatotoxic effects and acute pancreatitis.

    Small overdoses of the drug with simultaneous use with barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants and other stimulants of microsomal oxidation increase the possibility of developing severe intoxications.

    Inhibitors of microsomal oxidation (cimetidine) reduce the risk of hepatotoxic effects.

    Metoclopramide and domperidone increase, and colestramine reduces absorption.

    Special instructions:

    Therapy lasting more than a week requires control over the picture of peripheral blood and the functional state of the liver.

    Is able to change the results of doping control tests of athletes.

    The use of the drug makes it difficult to establish a diagnosis with an acute "acute abdomen."

    The use of the drug increases the risk of allergic diseases in patients suffering from atopic bronchial asthma and pollinosis.

    It is required to refuse alcoholic beverages for the entire treatment period.

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