Included in the formulation
АТХ:G.03.A.D Preparations for emergency contraception
G.03.A.D.01 Levonorgestrel
Pharmacodynamics:As a contraceptive agent causes changes in the endometrium, preventing the implantation of a fertilized egg. It inhibits the process of ovulation, increases the viscosity of cervical mucus, preventing the progress of spermatozoa.
Pharmacokinetics:After oral intake absorbed quickly and completely (bioavailability 100%). The maximum concentration in the blood plasma is reached after 1-1.5 hours. It binds to plasma proteins by 97.5%. Metabolised in the liver.
The elimination half-life is 24.4 hours. Elimination by the kidneys.
Indications:It is used as an emergency contraceptive. Used in combination hormone replacement therapy.
XXI.Z30-Z39.Z30.0 General advice and advice on contraception
Contraindications:Tumors of the mammary glands, acute liver disease, intracranial hypertension (including in history),thrombophlebitis and thromboembolism in history, undiagnosed bleeding from genital organs and urinary tract, diabetes mellitus complicated by angiopathy, ischemic heart disease.
Individual intolerance.
Carefully:Diseases of the liver and bile ducts, Crohn's disease, jaundice, including in the anamnesis.
Pregnancy and lactation:Recommendations for FDA - Category X. During pregnancy and lactation, the drug is contraindicated.
Dosing and Administration:Inside 0.75 mg for 72 hours after unprotected intercourse. Repeated reception in the same dosage after 12 hours. Either 1.5 mg once for 72 hours after intercourse.
The highest daily dose: 1.5 mg.
The highest single dose: 1.5 mg.
Side effects:Central and peripheral nervous system: intracranial hypertension, bulbospinal paralysis, headache, emotional lability, fast fatigue.
The cardiovascular system: thrombophilia.
Digestive system: nausea, vomiting, flatulence.
Reproductive system: metrorrhagia, amenorrhea, the formation of ovarian cysts, fibrocystic mastopathy.
Sense organs: intolerance to contact lenses.
Dermatological manifestations: itching, alopecia.
Allergic reactions.
Overdose:Increased side effects, vaginal bleeding.
Interaction:The contraceptive effect decreases with simultaneous use with cytochrome P450 inducers. Preparations: amprenavir, nevirapine, lansoprazole, oxcarbazepine, topiramate, trithionine, tacrolimus, barbiturates (including primidon), phenytoin, carbamazepine, rifampicin, tetracycline, ampicillin, griseofulvin and means containing St. John's wort (Hypericum perforatum) reduce the effectiveness of levonorgestrel.
When used simultaneously with cyclosporine, the risk of toxicity increases.
Levonorgestrel affects the effectiveness of anticoagulants and hypoglycemic drugs.
Special instructions:Use the drug for "emergency contraception" is not recommended several times during the same menstrual cycle.
In patients with overweight, the contraceptive effect of the drug is lowered.