Included in the formulation
АТХ:R.06.A.E. Piperazine derivatives
E.06.A.E.09 Levocetirizine
Pharmacodynamics:A competitive histamine antagonist with high selectivity to H1 - histamine receptors. Inhibiting eotaxins, levocetirizine blocks the expression of the vascular molecule of cell adhesion 1 in the histamine-dependent stage of the allergic reaction. As a result, the migration of eosinophils decreases, the vascular permeability decreases, and the release of inflammatory mediators is limited.
Levocetirizine prevents and slows the course of the allergic reaction, has antiexudative and antipruritic effect. Does not have antiserotonin and anticholinesterase, as well as sedation. Does not affect the parameters of the electrocardiogram (QT-interval).
Pharmacokinetics:Bioavailability is 100%. It binds to plasma proteins by 90%. Undergoes biotransformation in the liver - a dealkylation reaction takes place with the formation of an inactive metabolite.
The half-life is 7-10 hours.
Elimination by the kidneys - 85,4%. Removed during hemodialysis.
Indications:It is used for the treatment of seasonal and all-year-round allergic rhinitis, allergic conjunctivitis, hay fever, hives, allergic dermatoses. Used for swelling of Quincke.
VII.H10-H13.H10.1 Acute atopic conjunctivitis
X.J30-J39.J30.1 Allergic rhinitis caused by pollen of plants
X.J30-J39.J30.3 Other allergic rhinitis
XII.L20-L30.L20.8 Other atopic dermatitis
XII.L20-L30.L23 Allergic contact dermatitis
XII.L20-L30.L29 Itching
XII.L50-L54.L50 Hives
XIX.T66-T78.T78.3 Angioedema
Contraindications:Severe renal insufficiency (creatinine clearance less than 10 ml / min).
Individual intolerance.
Carefully:Elderly, as there is a decrease in glomerular filtration.
Pregnancy and lactation:Recommendations for FDA - Category B. It enters the breast milk. During pregnancy and lactation, the use of levocetirizine is contraindicated.
Dosing and Administration:It is applied from the age of 6 to 5 mg once a day.
Inside of 5 mg (1 tablet) a day at a time, regardless of the time of eating, without chewing.
The highest daily dose: 5 mg.
The highest single dose: 5 mg.
Side effects:Central and peripheral nervous system: headache, cramps, agitation.
The cardiovascular system: rarely - tachycardia.
Respiratory system: dyspnoea.
Digestive system: dry mouth, rarely - dyspeptic disorders.
Sense organs: transient visual disturbances.
Allergic reactions.
Overdose:Stimulation of the central nervous system: convulsions, insomnia, hallucinations.
Treatment is symptomatic.
Interaction:Strengthening the inhibitory effect on the central nervous system with the simultaneous use of barbiturates, narcotic analgesics, neuroleptics, alcohol.
Special instructions:Do not exceed a single dose and a higher single dose of 5 mg.
For children from 2 years, special dosage forms are used in the form of solutions, which are dosed in drops.