Included in the formulation
Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):VED
ONLS
АТХ:P.02.C.A.01 Mebendazole
P.02.C.A Benzimidazole derivatives
Pharmacodynamics:Anthelminthic drug of a wide spectrum of action; most effective in enterobiosis and trichocephalosis. Suppress microtubule assembly by binding to nematode β-tubulin, causing a slowdown in glucose transport and uncoupling of oxidative phosphorylation; suppression of mitochondrial fumar reductase activity and loss of mobility and helminth mortality due to lack of adenosine triphosphatea.
Pharmacokinetics:Virtually not absorbed in the intestine. Half-life - 2,5-5,5 hours. The connection with plasma proteins is 90%. It is distributed unevenly in the organs, accumulates in adipose tissue, liver, larvae of helminths. In the liver, it is metabolized to a 2-amino derivative. More than 90% of the dose is excreted with caloric masses in unchanged form. The absorbed part (5-10%) is excreted by the kidneys. The half-life period increases with hepatic insufficiency up to 35 hours.
Indications:Enterobiosis, ascariasis, ankylostomidosis, strongyloidiasis, trichocephalosis, multiple nematodes, echinococcosis, teniosis, alveococcosis, capillarial disease,gnathostomosis, trichinosis, mixed helminthiases.
I.B65-B83.B67.8 Echinococcosis of liver, unspecified
I.B65-B83.B67 Echinococcosis
I.B65-B83.B68 Teniosis
I.B65-B83.B75 Trichinosis
I.B65-B83.B76 Ankylostomiasis
I.B65-B83.B77 Ascaridosis
I.B65-B83.B78 Strontyloidosis
I.B65-B83.B79 Trichurosis
I.B65-B83.B80 Enterobiosis
I.B65-B83.B81.4 Intestinal helminthiases of mixed etiology
I.B65-B83.B83.1 Gnathostomy
Contraindications:Hypersensitivitynonspecific ulcerative colitis, Crohn's disease, liver failure, pregnancy, breast-feeding, children under 2 years old.
Carefully:Inflammatory bowel disease.
Pregnancy and lactation:The action category for fetus by FDA is C.
For the duration of treatment, breastfeeding should be discontinued.
Dosing and Administration:Inside. When enterobiosis: adults and children over 10 years - 100 mg once, children 2-10 years - 25-50 mg once. In the case of high probability of re-invasion - again after 2-4 weeks in the same doses. It is recommended that all members of the family be treated at the same time.
With ascariasis, trichocephalosis, ankylostomiasis, teniosis, strongyloidiasis and mixed helminthiasis: 100 mg in the morning and in the evening for 3 days.
When trichinosis: 200-400 mg 3 times a day for 3 days, and from the 4th to the 10th - 400-500 mg 3 times a day.
With echinococcosis: 500 mg twice a day for the first 3 days and 3 times a day for the next 3 days. In the future, the dose is raised to the maximum (at the rate of 25-30 mg / kg per day) in 3-4 doses.
Side effects:From the digestive system: rarely - nausea, abdominal pain; when used in high doses for a long time, vomiting, diarrhea, transient increase in the activity of hepatic transaminases in the blood serum.
From the side of the central nervous system: rarely - dizziness; when used in high doses for a long time - a headache.
On the part of the hematopoiesis system: when used in high doses for a long time, possible leukopenia, anemia, eosinophilia.
From the urinary system: when used in high doses for a long time - hematuria, cylindruria.
Other: when used in high doses for a long time - allergic reactions, hair loss.
Overdose:Symptoms: abdominal pain, nausea, vomiting, diarrhea. When used in high doses for a long time: reversible violations of the liver, hepatitis, neutropenia.
Treatment: it is necessary to remove the drug from the stomach, causing vomiting or rinsing the stomach, taking activated carbon.
Interaction:Carbamazepine, phenytoin - decrease in serum concentration of mebendazole.
Cimetidine is an increase in the serum concentration of mebendazole.
Insulin is an increase in hypoglycemic action of insulin.
Special instructions:Periodic examination of the anal and feces smears after the end of treatment is mandatory: therapy is considered effective in the absence of helminths or their eggs for 7 consecutive days. It is necessary to avoid sharing with alcohol and fatty foods, laxatives. It is necessary to control the picture of peripheral blood, liver and kidney function.