Worming - instructions for use, doses, side effects, contraindications

Active substanceMebendazoleMebendazole

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Vermox

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GEDEON RICHTER, OJSC Hungary

Worming

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Cadil Pharmaceuticals Co., Ltd. India

Helmedazole

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AVVA RUS, OJSC Russia

Dosage form: & nbsppills

Composition:

1 tablet contains:

Active substance: mebendazole 100 mg

Auxiliary components: calcium hydrogen phosphate 132.0 mg, starch corn 50.0 mg, gelatin 5.0 mg, talc purified 6.0 mg, magnesium stearate 3.0 mg, sodium lauryl sulfate 1.5 mg, vanillin 0.582 mg, dye sunset yellow ( FCF) 0.08 mg, Orange Flavor (DC116) 0.582 mg.

Description:

Round, flat, light orange color tablets with bevelled edges and a smell of vanillin.

Pharmacotherapeutic group:Anthelminthic remedy

ATX: & nbsp

P.02.C.A.01 Mebendazole

P.02.C.A Benzimidazole derivatives

Pharmacodynamics:

Anthelminthic drug of a wide spectrum of action; most effective against Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni. Causing an irreversible violation of glucose utilization, depletes glycogen stores in helminth tissues, interferes with the synthesis of cellular tubulin, and also inhibits the synthesis of ATP.

Pharmacokinetics:

Virtually not absorbed in the intestine. After taking the drug at a dose of 100 mg twice a day for three consecutive days,the concentration in the blood plasma of mebendazole and its metabolite (2-amino derivative) does not exceed 0.03 μg / ml and 0.09 μg / ml, respectively. The connection with plasma proteins is 90%. It is distributed unevenly in the organs, accumulates in adipose tissue, liver, larvae of helminths. In the liver, it is metabolized to a 2-amino derivative, which does not have anthelmintic activity. The half-life is between 3 and 6 hours. More than 90% of the dose is excreted intestine unchanged. About 10% is excreted by the kidneys.

Indications:

Enterobiosis, ascariasis, ankylostomidosis, strongyloidosis, trichocephalosis, teniosis, both with monoinvasion and mixed helminthiases; echinococcosis (with the impossibility of surgical treatment), trichinosis.

Contraindications:

Hypersensitivity to mebendazole, other components of the drug, ulcerative colitis, Crohn's disease, hepatic insufficiency, children's age (up to 3 years), simultaneous reception with metronidazole, phenytoin, carbamazepine, ritonavir.

Pregnancy and lactation:The use of the drug during pregnancy and during lactation is contraindicated.

Dosing and Administration:

Inside, with a little water.If necessary, the tablet can be chewed, crushed and mixed with food.

Adults and children over 3 years of age: when enterobiosis - once, 100 mg. In the case of a high probability of repeated invasion take again after 2-4 weeks at the same dose. It is recommended that all members of the family be treated at the same time. Ascariasis, trihotsefaleze, ankilostomidoze, taeniasis, strongyloidiasis and mixed helminthiasis - morning and evening 100 mg for 3 days. If the symptoms persist, it is recommended to repeat the course of treatment after 3 weeks.

Adults and children over 14 years of age: with echinococcosis in the first 3 days - 500 mg 2 times a day, in the following 3 days the dose is increased to 500 mg 3 times a day; in the future, the dose is increased to 1000-1500 mg 3 times a day. The average duration of treatment of echinococcosis caused by Echinococcus granulosus 4-6 weeks, caused by Echinococcus multilocularis - up to two years.

In trichinellosis on day 1, 3 times a day for 200-300 mg, on the second day 4 times a day for 200-300 mg, and from 3 to 14 days - 3 times a day for 500 mg.

Side effects:

Allergic reactions: skin rash, hives, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, exanthema, anaphylactic and anaphylactoid reactions.

From the hematopoiesis: leukopenia, neutropenia, eosinophilia, anemia.

On the part of the digestive system: vomiting, diarrhea, nausea, abdominal pain; increased activity of "liver" transaminases, alkaline phosphatase, hepatitis (when used in high doses for a long time).

From the central nervous system: dizziness, headache, drowsiness, convulsions.

From the urinary system: hyperkreatininemia, hematuria, cylindruria, glomerulonephritis (when used in high doses for a long time).

Other: hair loss.

May have a negative effect on the development of the fetus.

Overdose:

Symptoms: abdominal pain, nausea, vomiting, diarrhea. When used in high doses for a long time: reversible violations of the liver, hepatitis, neutropenia.

Treatment: gastric lavage, reception of activated charcoal, symptomatic therapy. There is no specific antidote.

Interaction:

Reduces the need for insulin in patients with diabetes mellitus.

Avoid joint use with lipophilic agents.

Cimetidine can increase the concentration of mebendazole in blood plasma, carbamazepine and other metabolism inducers-lower.

Special instructions:

At long reception it is necessary to supervise a picture of peripheric blood, function of a liver and kidneys.

When concomitant with cimetidine, it is necessary to monitor the concentration of mebendazole in the blood plasma and adjust the dose of the drug Vormin (especially with prolonged use).

In patients with diabetes it is necessary to monitor the level of glucose in the blood plasma.

Within a day after taking, ethanol, fatty foods are not allowed, and no laxative is prescribed.

In case of missed dose, the missed dose should be taken as soon as possible, and the subsequent dose at the recommended interval.

Periodic examination of the anal and feces smears after the end of treatment is mandatory: therapy is considered effective in the absence of helminths or their eggs for 7 consecutive days.

Effect on the ability to drive transp. cf. and fur:Patients who take Vormin should refrain from driving and other potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Form release / dosage:Tablets of 100 mg.

Packaging:

2 tablets in PVC / aluminum blister. 1 or 3 blisters are packed in a pack of cardboard with instructions for use.

For 3 tablets in PVC / aluminum blister. 1 or 2 blisters are packed in a pack of cardboard with instructions for use.

For 6 tablets in PVC / aluminum blister. 1 or 4 blisters are packed in a pack of cardboard with instructions for use.

Storage conditions:At a temperature not higher than 25 ° C, in a place not accessible to children.

Shelf life:

4 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:П N011662 / 01

Date of registration:20.06.2011 / 18.10.2012

Expiration Date:Unlimited

The owner of the registration certificate:Cadil Pharmaceuticals Co., Ltd.Cadil Pharmaceuticals Co., Ltd. India

Manufacturer: & nbsp

CADILA PHARMACEUTICALS, Ltd. India

Representation: & nbspCADILA PHARMACEUTICALS LTD. CADILA PHARMACEUTICALS LTD. India

Information update date: & nbsp10.03.2017

Illustrated instructions

Instructions

Worming (Wormin)