Vermox - instructions for use, dose, side effects, contraindications

Active substanceMebendazoleMebendazole

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GEDEON RICHTER, OJSC Hungary

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Dosage form: & nbsppills

Composition:For 1 tablet:

Active substance: mebendazole 100 mg;

Excipients: sodium lauryl sulfate 0.5 mg, silicon dioxide colloid - 1.5 mg, magnesium stearate 3 mg, sodium saccharinate 5 mg, talc 9 mg, corn starch 71 mg, lactose monohydrate 110 mg.

Description:Ploskotsilindricheskie tablets white or almost white with a slight characteristic smell, with a facet, with the inscription "VERMOX" on one side and risk on the other.

Pharmacotherapeutic group:Anthelmintic means

ATX: & nbsp

P.02.C.A.01 Mebendazole

P.02.C.A Benzimidazole derivatives

Pharmacodynamics:A broad-spectrum anthelmintic preparation is most effective against Enterobius vermicularis, Trichuris trichiura, Ascaris Iumbricoides, Ancylostoma, duodenale, Necator americanus, Strongyloides stercoralis, Taenia solium, Echinococcus d. Granulosus, Echinococcus multilocularis, Trichinella spiralis, Trichinella nativa, Trichinella nelsoni. Causing an irreversible violation of glucose utilization, depletes glycogen stores in helminth tissues, interferes with the synthesis of cellular tubulin, and also inhibits the synthesis of adenosine triphosphate (ATP).

Pharmacokinetics:Virtually not absorbed in the intestine. After taking the drug at a dose of 100 mg twice a day for three consecutive days, the concentration in the blood plasma of mebendazole and itsmetabolite (2-amino derivative) does not exceed 0.03 μg / ml and 0.09 μg / ml, respectively. The connection with plasma proteins is 90%. It is distributed unevenly in the organs, accumulates in adipose tissue, liver, larvae, helminths. In the liver, it is metabolized to a 2-amino derivative, which does not have anthelmintic activity. Half-life. 2,5-5,5 hours. More than 90% of the dose is removed through the intestine in an unchanged form. The absorbed part (5-10%) is excreted by the kidneys.

Indications:Enterobiosis, ascariasis, ankylostomidosis, strongyloidosis, trichocephalosis, trichinosis, teniosis, echinococcosis, teniosis, both with monoinvasion and mixed helminthiases; echinococcosis (with the impossibility of surgical treatment).

Contraindications:Hypersensitivity to mebendazole, other components of the drug, ulcerative colitis, Crohn's disease, liver failure, children under 3 years of age, pregnancy, lactation, lactose intolerance, lactase deficiency, glucose-galactose malabsorption; simultaneous, reception with metronidazole, phenytoin, carbamazepine, ritonavir.

Pregnancy and lactation:Use during pregnancy is contraindicated. There is no data on whether the mebendazole in mother's milk.If necessary - use the drug during lactation breastfeeding is recommended to stop.

Dosing and Administration:Inside with a little water. Adults and children older than 3 years with enterobiosis - once, 100 mg and mixed helminthiases - in the morning and in the evening for 100 mg for 3 days. If the symptoms persist, it is recommended to repeat the course of treatment after 3 weeks. Adults and children over 14 years of age: with echinococcosis in the first 3 days - 500 mg. 2 times a day, in the following 3 days the dose is increased to 500 mg. 3 times a day; in the future, the dose is increased to 1000 - 1500 mg. 3 times a day. The average duration of treatment for echinococcosis caused by Echinococcus, granulosus, is 4-6 weeks, caused by Echinococcus multilocularis - up to two years. In trichinellosis on day 1, 3 times a day for 200-300 mg, on the second day 4 times a day for 200-300 - mg, from 3 to 14 days - 3 times a day for 500 mg.

It is recommended to conduct simultaneous treatment of all family members. With ascariasis, trichocephalosis, ankylostomiasis, teniosis, strongyloidiasis and mixed helminthiases, morning and evening for 100 mg for 3 days.

Side effects:Allergic reactions: urticaria, angioedema, Stevens-Johnson syndrome, toxic epidermal necrolysis, exanthema,anaphylactic and anaphylactoid reactions.

On the part of the organs of hematopoiesis: neutropenia.

On the part of the digestive system: nausea, vomiting; abdominal pain, diarrhea, increased activity of "liver" transaminases, alkaline phosphatase, hepatitis (when used in high doses for a long time).

From the nervous system: dizziness, headache, drowsiness, convulsions.

From the urinary system: hyperkreatininemia, glomerulonephritis (when used in high doses for a long time).

Deviations in the results of laboratory studies: leukopenia, anemia, eosinophilia (when used in high doses for a long time).

Other: loss of hair (when used in high doses for a long time).

Overdose:Symptoms: abdominal pain, nausea, vomiting, diarrhea. When used in high doses for a long time: reversible violations of the liver, hepatitis, neutropenia.

Treatment: it is necessary to remove the drug from the stomach, causing vomiting or rinsing the stomach, taking activated charcoal.

Interaction:Reduces the need for insulin in patients with diabetes mellitus.Do not take with lipophilic substances at the same time.

Cimetidine can increase the concentration of mebendazole in the blood, carbamazepine and others - inductors of metabolism - are lowered, in connection with which it is necessary to control the concentration of drugs in the blood serum.

Special instructions:The drug contains lactose, so patients with rare hereditary lactose intolerance, lactase deficiency or impaired glucose / galactose absorption should not take this drug.

In patients with diabetes it is necessary to monitor the concentration of glucose in the blood plasma.

At long reception it is necessary to supervise a picture of peripheric blood, function of a liver and kidneys.

Within a day after taking, ethanol, fatty foods are not allowed, and no laxative is prescribed.

Periodic examination of the anal and feces smears is mandatory, after the end of treatment: therapy is considered effective in the absence of helminths or their eggs for 7 consecutive days.

Effect on the ability to drive transp. cf. and fur:Patients should be careful when driving vehicles and working with machinery,because during treatment, dizziness may occur and drowsiness may occur.

Form release / dosage:Tablets of 100 mg.

Packaging:For 6 tablets in a blister of PVC and aluminum foil. 1 blister together with instructions for use are placed in a cardboard box.

Storage conditions:Store at a temperature of 15-30 ° C.
Keep out of the reach of children.

Shelf life:5 years.

Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:П N013647 / 01

Date of registration:29.12.2011

Expiration Date:Unlimited

The owner of the registration certificate:GEDEON RICHTER, OJSC GEDEON RICHTER, OJSC Hungary

Manufacturer: & nbsp

GEDEON RICHTER ROMANIA, S.A. Romania

Representation: & nbspGEDEON RICHTER OJSC GEDEON RICHTER OJSC Hungary

Information update date: & nbsp29.01.2017

Illustrated instructions

Instructions

Vermox (Vermox)