Acetecacin (Acemethacinum)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

NSAIDs - Derivatives of acetic acid and related compounds

Included in the formulation
  • Rantudil retard
    capsules inwards 
    Honey Manufacuring GmbH     Germany
  • Rantudil Forte
    capsules inwards 
    Honey Manufacuring GmbH     Germany
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    ONLS

    АТХ:

       

    M.01.A.B.11   Acetecacin

    Pharmacodynamics:

    It does not selectively suppress COX-1 and COX-2 regulating the synthesis of prostaglandins. Has analgesic, antipyretic and anti-inflammatory effect.

    Reduces thrombosis, aggregation and adhesion of platelets, suppressing the synthesis of thromboxane A2 in thrombocytes.

    Pharmacokinetics:

    After oral administration, it is completely absorbed in the gastrointestinal tract. It binds to blood plasma proteins in 99% and circulates in the form of the main drug - acetemethacin and its metabolite - indometacin in a ratio of 1: 1. It accumulates in the hearth of inflammation.

    Half-Elimination (half-life) of the drug is 4.5 hours.

    Indications:It is used for chronic rheumatoid arthritis, psoriatic arthritis, Bechterew disease, myositis, thrombophlebitis of superficial veins.
    ICD-10

    IX.I80-I89.I80   Phlebitis and thrombophlebitis

    XIII.M05-M14.M05.8   Other seropositive rheumatoid arthritis

    XIII.M05-M14.M10   Gout

    XIII.M60-M63.M60   Myositis

    Contraindications:

    Peptic ulcer of stomach and duodenum, violation of blood coagulation and hematopoiesis, hyperkalemia.

    Individual intolerance to non-steroidal anti-inflammatory drugs and aspirin.

    Carefully:

    Children under the age of 12 with hyperthermia on the background of viral infections are a danger of developing Reye's syndrome. Chronic heart failure, active inflammatory processes of the liver, chronic renal failure, the use of diuretics. Hemophilia, systemic lupus erythematosus.

    Pregnancy and lactation:Pregnancy and lactation: recommendations for Food and Drug Administration (US Food and Drug Administration) - Category C. The use during pregnancy is contraindicated in III trimester. AT I and II trimesters, and also during lactation aceclofenac is prescribed in situations where the risk from taking the drug is lower than the expected efficacy.
    Dosing and Administration:

    Inside: 60 mg 1-3 times a day.

    If necessary, patients with gout in the acute stage increase the dose to 300 mg per day: 120 mg once, then 60 mg every 8 hours.

    The highest daily dose: 600 mg.

    The highest single dose: 120 mg.

    Side effects:

    Central and peripheral nervous system: dizziness, agitation, headache, depression, cognitive disorders, sleep disorders, tremor, paresthesia, aseptic meningitis.

    Cardiovascular system: arterial hypertension, tachycardia.

    The system of hematopoiesis: leukopenia, thrombocythemia, agranulocytosis, aplastic anemia.

    Digestive system: gastralgia, dyspeptic disorders, anorexia, melena, constipation.

    Urinary system: peripheral edema, proteinuria.

    Allergic reactions.

    Overdose:

    Increased side effects, hyperventilation of the lungs, convulsive alertness.

    Treatment is symptomatic.

    Interaction:

    Not compatible with alcohol.

    Increases the concentration in the plasma digoxin, phenylthionine, lithium preparations.

    Reduces the effectiveness of diuretics and antihypertensive drugs.

    Increases the toxicity of methotrexate - recommended interval between taking drugs in 24 hours.

    The concentration of the drug in the blood plasma is reduced with the simultaneous use of acetylsalicylic acid.

    Changes the effect of oral hypoglycemic drugs: hypo- or hyperglycemia.

    Special instructions:

    It can slow down the reaction rate when driving vehicles and controlling machinery.

    Instructions
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