The incidence of side effects is defined as follows (number of patients who showed this reaction):
Very often:> 1/10;
Often: <1/10> 1/100;
Infrequently: <1/100> 1/1000;
Rarely: <1/1000> 1/10000;
Very rarely: <1/10000.
From the gastrointestinal tract:
Very often: indigestion: nausea, vomiting, flatulence, abdominal pain, loss of appetite.
Often: ulcerative lesions in the gastrointestinal tract (GIT), sometimes accompanied by bleeding and perforation.
Infrequent: presence of blood in vomit, feces or with diarrhea.
Very rarely: stomatitis, inflammation of the tongue, lesion of the esophagus, exacerbation of Crohn's disease or ulcerative colitis, constipation, pancreatitis.
From the nervous system:
Often: disorders of the central nervous system, including headache, lethargy / fatigue, dizziness, drowsiness.
Very rarely: muscular asthenia, hyperhidrosis, dysgeusia, memory disorders, sleep disorders, convulsions.
From the cardiovascular system:
Very rarely: increased heart rate, angina pectoris, heart failure, hypertension.
From the liver and biliary tract:
Often: increased levels of liver enzymes.
Infrequent: liver damage (toxic hepatitis with or without jaundice, very rarely: lightning and sometimes without previous symptoms).
From the side of the circulatory system:
Very rarely: anemia caused by the loss of latent blood from the digestive tract, hemolytic anemia, pancytopenia (anemia, including aplastic anemia, leukopenia, agranulocytosis, thrombocytopenia). Initial symptoms may include fever, sore throat, superficial lesions in the oral cavity, flu-like conditions, severe fatigue, nosebleeds and subcutaneous bleeding.
In these cases, you must immediately stop taking the drug and see a doctor. Do not take analgesics and / or antipyretics yourself.
In the case of prolonged treatment, a blood test should be performed regularly.
Possible effects on platelet aggregation and increased hemorrhagic diathesis.
From the immune system:
Often: reactions of hypersensitivity (rash and itching).
Infrequently: urticaria.
Very rarely: severe hypersensitivity reactions: edema of the face or eyelids, swelling of the tongue, angioneurosis, respiratory distress, which can lead to an attack of asthma,lowering of blood pressure.
Very rarely: allergic vasculitis and pneumonitis.
From the endocrine system:
Very rarely: hyperglycemia and glucosuria.
On the part of the organs of vision:
Uncommon: retinal pigment degeneration, blurred cornea during long-term use of indomethacin, acemetacin main metabolite.
From the organs of hearing:
Very rare: tinnitus and hearing loss
From the skin and subcutaneous tissue:
Infrequently: alopecia
Very rarely, eczema, enanthema, erythema, photosensitivity, exfoliative dermatitis and bullous rashes that may also have severe course, e.g., in the form of Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome).
From the urinary system:
Infrequent: the development of edema, in particular, in patients with hypertension and / or impaired renal function.
Very rare: micturition disorders, increase in urea levels in the blood, acute renal failure, proteinuria, hematuria, interstitial nephritis, nephrotic syndrome, papillary necrosis.
In this regard, the indicators of kidney function of the patient should be regularly monitored.