Zinc bisvinylimidazole diacetate (Zinci bisvinylimidazoli diacetas)

Pharmacodynamics Pharmacokinetics Indications Carefully Contraindications Dosing and Administration Side effects
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Clinical and pharmacological group: & nbsp

Detoxifying agents, including antidotes

Included in the formulation
  • Acisol®
    capsules inwards 
    Nizhny Novgorod Chemical and Pharmaceutical Plant, OJSC    
  • Acisol®
    solution w / m 
    Nizhny Novgorod Chemical and Pharmaceutical Plant, OJSC    
    • Included in the list (Order of the Government of the Russian Federation No. 2782-r of 30.12.2014):

    VED

    АТХ:

    V.03.A.B   Antidotes

    Pharmacodynamics:

    Prevents the formation of carboxyhemoglobin due to the influence on the cooperative interaction of hemoglobin subunits, resulting in a decrease in the relative affinity of hemoglobin to carbon monoxide, improve oxygen binding (decrease in the Hill constant), and gas transport properties of blood.

    Reduces the severity of intoxication during carbon monoxide poisoning in terms of the severity of metabolic acidosis, accelerates the elimination of carbon monoxide (CO) from the body.

    Reduces the body's need for oxygen, promotes an increase in resistance to hypoxia of organs most sensitive to lack of oxygen: the brain, myocardium, liver, etc.

    It is a complex zincorganic compound and replenishes zinc deficiency in the body.

    Pharmacokinetics:

    The maximum concentration of the drug in the blood is reached in 20-30 minutes after intramuscular injection of 1 ml (60 mg) of the drug and stored in blood plasma for 4-5 o'clock. The half-life is 1-1.5 hours. It is mainly metabolized by the liver.

    When administered orally zinc bisvinylimidazole diacetate quickly absorbed from the gastrointestinal tract. The maximum concentration in the blood plasma is reached after 1-1,5 hours. It is mainly metabolized by the liver. Metabolism products are excreted through the gastrointestinal tract. The half-life is 1-1.5 hours, after 8-10 hours, trace amounts of the drug are recorded.

    Indications:

    They are used as a prophylactic agent for the threat of poisoning and a remedy for poisoning with varying degrees of severity by carbon monoxide (CO) and other products of thermooxidative destruction.

    ICD-10

    XIX.T51-T65.T58   Toxic effect of carbon monoxide

    XX.X40-X49.X47   Accidental poisoning and exposure to other gases and vapors

    XIX.T51-T65.T59   Toxic effect of other gases, fumes and vapors

    Contraindications:

    Hypersensitivity to the main and / or auxiliary components of the drug; breast-feeding; children under 18 years of age (due to insufficient data).

    Carefully:

    Deficiency of copper.

    Pregnancy and lactation:

    Category by FDA not determined. In experimental studies on animals, embryotoxic and teratogenic properties, as well as adverse effect on the reproductive function of zinc bisvinilimidazole diacetate, were not revealed. Adequate and strictly controlled studies involving pregnant women were not conducted. The use of the drug in pregnant women as an antidote for carbon monoxide (II) poisoning is justified.

    There are no data on the penetration of zinc bisvinilimidazole diacetate into breast milk. During the use of the drug should stop breastfeeding.

    Dosing and Administration:

    Intramuscularly. With the preventive purpose, the drug is administered in a dose of 1 ml intramuscularly for 20-30 minutes before entering the smoke zone (gas contamination), with a high risk of CO inhalation, during the work on extinguishing the fires themselves and rescuing the victims. The protective effect is maintained for 1.5 to 2 hours. Repeated use of the drug is allowed 1 hour after the first administration.

    With a therapeutic purpose, it is recommended to use as early as possible after poisoning, regardless of the severity of the lesion.The drug is administered in a dose of 1 ml intramuscularly immediately after removal of the victim from the fire zone (gassed room). Repeated administration is allowed 1 hour after the first administration. In the future, intramuscularly administered 1 ml 2-4 times a day. The maximum daily dose for an adult is 240 mg (4 ml). The average course of treatment is 7-10 days.

    Inside. With the preventive purpose - 1 capsule (120 mg) for 30-40 minutes before entering the smoke (gas) zone, with a high risk of CO inhalation, during the work to eliminate the consequences of accidents and catastrophes, accompanied by fires, or when extinguishing the fires themselves and rescue of the victims. The protective effect is maintained for 2-2.5 hours. Repeated reception of the drug is allowed after 1.5-2 hours.

    Due to the specificity of the action, safety and the absence of negative effects on physical and mental performance, prolonged exposure or poisoning with carbon monoxide (II), repeated use of the drug is allowed - on the first day of 1 capsule (120 mg) 4 times, followed by 1 capsule 2 times a day for 7 days. The maximum daily dose for an adult is 480 mg (4 capsules).

    When carbon monoxide (II) is poisoned, it is recommended to start using the drug at the earliest possible time along with other medications.

    Side effects:

    Intramuscularly. Side effect is not revealed. In some cases, moderate pain in the place of administration of the drug.

    When ingested on an empty stomach, a feeling of nausea may appear.

    Overdose:

    Symptoms: metallic taste in the mouth, headache, nausea. These phenomena occur after the drug is discontinued.

    Interaction:

    It is not recommended to be used together with sodium dimercaptopropanesulfonate.

    When prescribed with other medicines, no negative effects were noted.

    Special instructions:

    The drug in the form of capsules contains lactose, therefore it is not recommended to use patients who have rare hereditary problems of lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome.

    Instructions
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