It is known that under the influence of elevated concentrations of carbon monoxide (II), the so-called Holden effect is manifested when, as a result of cooperative interaction of the heme 4 hemoglobin, the hemoglobin molecule is deprived of the ability to give oxygen, if the remaining 3 heme bound carbon monoxide (II). Atsizol®, being integrated organozinc compound by reducing the cooperativity and relative affinity of the heme of hemoglobin to carbon monoxide (II), inhibits the formation of carboxyhemoglobin, resulting in improved oxygen-binding and transmission properties of the blood when poisoned by carbon monoxide (II), the elimination of carbon monoxide (II) is accelerated from the body. Increase in the affinity of hemoglobin for oxygen (O2) and the shift of the dissociation curve of oxyhemoglobin to the left allow hemoglobin to be completely saturated with oxygen at much lower values of the partial pressure O2, resulting in increased resistance of the body to a lack of oxygen in the environment. Difficulty in recoil2 tissue leads to a relative deterioration in the supply of O2 only organs and tissues with a high threshold of its assimilation, while vital organs with a low threshold of assimilation of O2, for example, the brain, are in a better situation than in the absence of a left shift.
Acizol®, contributing to the acceleration of elimination of carbon monoxide from the body, reduces the severity of intoxication during carbon monoxide (II) poisoning in terms of the severity of metabolic acidosis. It replenishes zinc deficiency in the body.