It is known that under the influence of elevated concentrations of carbon monoxide (II), the so-called Holden effect is manifested when, as a result of cooperative interaction of the heme 4 hemoglobin, the hemoglobin molecule is deprived of the ability to give oxygen, if the remaining 3 heme bound carbon monoxide (II). Acizol®, being a complex organozinc compound, due to a decrease in the cooperativity of the hemes and the relative affinity of hemoglobin to carbon monoxide (II), inhibits the formation of carboxyhemoglobin, which improves the oxygen-binding and gas transport properties of blood upon carbon monoxide poisoning, accelerates the elimination of carbon monoxide II) from the body. Increase in the affinity of hemoglobin for oxygen (O2) and the shift of the dissociation curve of oxyhemoglobin to the left allow hemoglobin to be completely saturated with oxygen at much lower O2 partial pressures, which increases the body's resistance to a lack of oxygen in the environment. Difficulty in recoil2 tissue leads to a relative deterioration in the supply of O2 only organs and tissues with a high threshold of its assimilation, while vital organs with a low threshold of assimilation of O2, for example, the brain, are in a better situation than in the absence of a left shift.
Acizol®, promoting the acceleration of elimination of carbon monoxide from the body,reduces the severity of intoxication during carbon monoxide (II) poisoning in terms of the severity of metabolic acidosis. It replenishes zinc deficiency in the body.