The drug Piperacillin-Tazobactam-Teva should be administered in the form of IV injections slowly for 3-5 minutes or infusions for 20-30 minutes.
The duration of treatment with Piperacillin-Tazobactam-Teva depends on the dynamics of the patient's condition and the results of bacteriological tests. The recommended duration of therapy is from 5 to 14 days. The drug should be used for at least 48 hours after the disappearance of all clinical symptoms of the disease.
Adults and children over 12 years of age:
The recommended dose is 4.5 g (4 g piperacillin / 0.5 g tazobactam) every 8 hours. The average daily dose depends on the severity and localization of the infectious process and can vary from 2.25 g (2 g piperacillin / 0.25 g tazobactam) to 4.5 g (4 g piperacillin / 0.5 g tazobactam) every 6-8 h .
In elderly patients correction of the dose is not required.
In adults and children with a body weight of more than 50 kg and kidney failure dosage adjustment depends on QC. With QC more than 40 ml / min dose adjustment is not required. At CC 20-40 ml / min - 12 g / 1.5 g / day (4 g piperacillin / 0.5 g tazobactam every 8 hours). At CC less than 20 ml / min - 8 g / 1 g / day (4 g piperacillin / 0.5 g tazobactam every 12 hours).
Patients in need of hemodialysis, the maximum daily dose is 9 g / day (8 g piperacillin / 1 g tazobactam / day). Since during the hemodialysis 30-50% of piperacillin is washed out after 4 hours, it is necessary to additionally inject 2.25 g (2 g piperacillin / 0.25 g tazobactam) after each hemodialysis session.
Children aged 2-12 years:
Intra-abdominal infections
In children with a body weight of less than 40 kg and normal kidney function the recommended daily dose is 112.5 mg / kg (100 mg / kg piperacillin / 12.5 mg / kg tazobactam) every 8 hours, no more than 4.5 g (4 g piperacillin / 0.5 g tazobactam) per administration. Duration of therapy is 5-14 days.
In children with a body weight of more than 40 kg and normal kidney function apply the same dose as in adults, i.e. 4.5 g (4 g piperacillin / 0.5 g tazobactam) every 8 h.
Bacterial infections on the background of concomitant neutropenia (in combination with aminoglycosides)
In children weighing less than 50 kg and normal kidney function the recommended daily dose of the drug is 90 mg / kg (80 mg / kg piperacillin / 10 mg / kg tazobactam) every 6 hours, no more than 4.5 g (4 g piperacillin / 0.5 g tazobactam) for administration, in combination with aminoglycosides .
In children with a body weight of more than 50 kg and normal kidney function apply the same dose as in adults, and inject it in combination with aminoglycosides.
In children with kidney failure the pharmacokinetics of piperacillin / tazobactam have not been studied.
In children with a body weight of less than 50 kg and kidney failure dosage adjustment depends on QC. At CC, more than 50 ml / min - 112.5 mg / kg (100 mg / kg piperacillin / 12.5 mg / kg tazobactam) every 8 hours. At CC less than 50 ml / min - 78.75 mg / kg (70 mg / kg piperacillin (8.75 mg / kg tazobactam) every 8 hours. This dose change is indicative.
Each patient should be monitored for the timely detection of signs of an overdose. It is necessary to adjust the dose of the drug and the interval between the administration of the next dose accordingly.
For children weighing less than 50 kg, in need of hemodialysis, the recommended dose is 45 mg / kg (40 mg / kg piperacillin / 5 mg / kg tazobactam) every 8 hours.
In patients with impaired liver function correction of the dose is not required.
Preparation of solution for intravenous administration
The drug Piperacillin-Tazobactam-Teva is used only for IV administration. The preparation is dissolved with one of the solvents compatible with the preparation Piperacillin-Tazobactam-Teva in accordance with the volume indicated in the table.The vial is rotated in a circular motion until the content is completely dissolved (with constant rotation, usually for 5-10 min). The resulting solution is a colorless or pale yellow liquid.
| Dosage / vial of the drug Piperacillin-Tazobactam-Teva | Volume of solvent (ml) |
| 2.25 g (2 g piperacillin / 0.25 g tazobactam) | 10 |
| 4.5 g (4 g piperacillin / 0.5 g tazobactam) | 20 |
Solvents compatible with the drug Piperacillin-Tazobactam-Teva: 0.9% solution of sodium chloride; sterile water for injections; 5% dextrose solution.
Then, to further dilute the drug to the required volume for intravenous infusion (for example, from 50 ml to 150 ml), the prepared solution is diluted with one of the following compatible solutions: 0.9% sodium chloride solution; sterile water for injections (the maximum recommended volume is 50 ml); 5% dextrose solution.
The prepared solution should be stored at a temperature of 2 to 8 ° C not more than 48 hours. If a "flake", a crystal is found in a prepared solution, including a change in its color or any other indication of pharmaceutical interaction or contamination, infusion should be stopped immediately.
To reduce the risk of microbial contamination of the drug Piperacillin-Tazobactam-Teva for intravenous administration, it is recommended that it be prepared immediately before infusion.
Unused for 48 hours, the prepared solution is not recommended for use and should be disposed of in accordance with local requirements.