Pirlegin (Pyralgin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceCodeine + Caffeine + Metamizol sodium + Naproxen + PhenobarbitalCodeine + Caffeine + Metamizol sodium + Naproxen + Phenobarbital
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  • Pirlegin
    pills inwards 
    BELMEDPREPARATY, RUP     Republic of Belarus
    • Dosage form: & nbsppills.
    Composition:

    Active substances: analgin (metamizol sodium) - 0.3 g, naproxen - 0.1 g, caffeine - 0.05 g, phenobarbital - 0.01 g, codeine - 0.008 g.

    Auxiliary substances: potato starch, talc, magnesium stearate.

    Description:

    Tablets from white with a yellowish or creamy hue to white with a yellow or cream shade of color, flat-cylindrical, with a risk and a facet.

    Pharmacotherapeutic group:Analgesic agent (analgesic opioid + non-steroidal anti-inflammatory drug + psychostimulant + barbiturate).
    ATX: & nbsp

    N.02.B.B.72   Metamizole sodium in combination with psycholeptics

    Pharmacodynamics:

    The drug has analgesic, antipyretic, anti-inflammatory, antispasmodic, sedative effect. Piralgin - a combined preparation that combines the properties of active ingredients. Metamizol sodium and naproxen - medicines of a group of non-narcotic analgesics, have antipyretic activity, analgesic activity, which is enhanced by codeine (blocks opiate receptors, stimulates the antinociceptive system and changes the emotional perception of pain). Naproxen also has a pronounced anti-inflammatory effect. Phenobarbital has a sedative effect. Caffeine causes expansion of blood vessels of skeletal muscles, brain, heart, kidneys; increases mental and physical performance, helps to eliminate fatigue and drowsiness; increases blood pressure in hypotension; increases the permeability of histohematological barriers and increases the bioavailability of non-narcotic analgesics, thereby contributing to the enhancement of the therapeutic effect.

    Pharmacokinetics:

    The components of the drug are well absorbed in the gastrointestinal tract.

    Metamizol sodium: in the intestinal wall it hydrolyses to form an active metabolite, 4-methyl-amino-antipyrine, which in turn is metabolized to 4-formyl-amino-antipyrine and other metabolites. The level of binding of the active metabolite with proteins is 50-60%. Excretion of metabolites passes through the kidneys. In addition, metabolites are excreted in breast milk.

    Naproxen: bioavailability is 95%. It binds to blood proteins. Period elimination half-life - 12-15 hours.It is excreted in the urine mainly in the form of a metabolite (dimethylnaproxen), in small amounts - with bile.

    Caffeine, well absorbed in the intestine, half-life -5h (sometimes - up to 10 hours). It is excreted mainly by kidneys in the form of metabolites, about 10% - in unchanged form. Codeine: slightly binds to plasma proteins. It is subject to biotransformation in the liver (10% by demethylation passes into morphine). Excreted by the kidneys (5-15% - unchanged).

    Phenobarbital: bioavailability is 80%. In plasma it binds to proteins by 50%, it penetrates well through the placenta. Biotransformatsya in the liver. The main metabolite does not have pharmacological activity. It is excreted by the kidneys, including 20-25% - unchanged.

    Indications:

    Piralgin is taken with a moderate pain syndrome of different genesis. It is especially effective for pains in the joints, muscles, radiculitis, menstrual pains, neuralgia, as well as headache, migraine, toothache. Piralgin can be used in febrile states, colds and other diseases, accompanied by pain syndrome and inflammation.

    Contraindications:Hypersensitivity to the components of the drug; marked violations of the liver or kidneys; deficiency of glucose-6-phosphate dehydrogenase; peptic ulcer of the stomach and duodenum in the stage of exacerbation; bronchospasm; blood diseases; conditions accompanied by respiratory depression; increased intracranial pressure, craniocerebral trauma; acute myocardial infarction; heart rhythm disturbances; high blood pressure; glaucoma; alcoholic intoxication; children's age - up to 12 years.
    Carefully:

    Carefully used in patients with impaired liver or kidney function, with peptic ulcer of the stomach and duodenum in remission, in the elderly, with prolonged alcohol history.

    When using the drug for more than 5 days, it is necessary to monitor the pattern of peripheral blood and the functional state of the liver.

    Taking the drug may make it difficult to diagnose an acute pain syndrome in the abdomen.

    Pregnancy and lactation:the drug is contraindicated for use in pregnancy. If it is necessary to use the drug during lactation, it is necessary to solve the problem of stopping breastfeeding.
    Dosing and Administration:

    The drug is taken orally, usually 1 tablet 1-3 times a day. The maximum daily dose is 4 tablets. The drug should not be taken more than 5 days as an anesthetic without prescribing a doctor.

    Side effects:

    Dyspeptic disorders (nausea, vomiting, constipation), skin allergic reactions (rash, itching, urticaria), epigastric pain, dizziness, drowsiness, palpitations are possible. Rarely is the oppression of hematopoiesis (leukopenia, granulocytopenia, agranulocytosis). With prolonged admission in high doses, it is possible that the liver and kidney function is impaired.

    Overdose:

    Symptoms: nausea, vomiting, stomach pain, tachycardia, cardiac arrhythmias, weakness, drowsiness, nonsense, respiratory depression.

    Treatment: induction of vomiting, over-the-horizon gastric lavage, the appointment of adsorbents (activated charcoal), symptomatic therapy aimed at maintaining vital functions.

    Interaction:

    Simultaneous use of the drug with other non-narcotic analgesics may lead to an increase in toxic effects. Tricyclic antidepressants, oral contraceptives, allopurino l increase the toxicity of metamizole sodium (analgin), which is part of the drug. Barbiturates, phenylbutazone and other inducers of microsomal liver enzymes weaken the action of metamizole sodium (analgin). Simultaneous use of metamizole sodium (analgin) with cyclosporine reduces the level of the latter in the blood. Sedatives and tranquilizers increase the analgesic effect of the drug.

    Special instructions:

    It is necessary to have medical control during the period of taking the drug.

    The patient should be informed that with prolonged use of the drug without appropriate medical control, it is possible to develop addiction and the formation of drug dependence.

    During the treatment with Piralgin it is necessary to refrain from drinking alcohol.
    Effect on the ability to drive transp. cf. and fur:Piralin can make it difficult to perform work that requires high speed of mental and physical reactions (driving vehicles, controlling mechanisms, devices, etc.).
    Form release / dosage:Pills.
    Packaging:10 tablets per contour cell pack. One, two contour packs with instructions for use are placed in a pack of cardboard.
    Storage conditions:

    Storage conditions

    In a dry, protected from light place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:Shelf life. 3 years. Do not use after the expiration date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:П N012815 / 01
    Date of registration:27.07.2007
    The owner of the registration certificate:BELMEDPREPARATY, RUP BELMEDPREPARATY, RUP Republic of Belarus
    Manufacturer: & nbsp
    BELMEDPREPARATY, RUP Republic of Belarus
    Information update date: & nbsp13.06.2012
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