Platifillin - instructions for use, dose, side effects, contraindications

M-holinoretseptor blocker. It has a myotropic spasmolytic and weak sedative effect. Reduces the tone of the smooth muscles of the gastrointestinal tract (GIT), bronchi. Reduces the secretion of salivary, lacrimal, bronchial, sweat glands. Expands the pupil, causes a moderately pronounced paralysis of accommodation and increased intraocular pressure.

Indications:

Peptic ulcer of the stomach and duodenum; for relief of bouts of spasmodic pain (intestinal, hepatic, renal colic); as an auxiliary agent for bronchospasm in patients with bronchial asthma.

Contraindications:

Hypersensitivity, zakratougolnaya glaucoma, cachexia, severe atherosclerosis, heart failure II-III st., Arrhythmias, tachycardia; hyperplasia of the prostate; hepatic and / or renal insufficiency; pyloroduodenal stenosis, diaphragmatic hernia in combination with reflux esophagitis, paralytic ileus, intestinal atony, bleeding from the gastrointestinal tract, megacolon complicated with ulcerative colitis; elderly and senile age.

Carefully:

Pregnancy; lactation period; cardiac ischemia; mitral stenosis; arterial hypertension; acute bleeding; thyrotoxicosis; increased body temperature; Gastrointestinal diseases accompanied by obstruction (including achalasia and stenosis of the pylorus); diseases with increased intraocular pressure (including open-angle glaucoma); age over 40 years (risk of manifestation of unidentified glaucoma); nonspecific ulcerative colitis; dry mouth; chronic lung diseases,especially in young children and weakened patients; myasthenia gravis; autonomic (autonomic) neuropathy (urinary retention and paralysis of accommodation may be aggravated); urinary retention or predisposition to it or diseases accompanied by obstruction of the urinary tract; gestosis; Down's disease; cerebral palsy.

Dosing and Administration:

For relief of acute pain in gastric and duodenal ulcer, intestinal, hepatic and renal colic, the drug is administered under the skin for 2-4 mg (1-2 ml of 0.2% solution). For the course treatment (10-20 days) is administered subcutaneously for 2-4 mg 2-3 times a day.

The highest dose for adults: single dose - 10 mg, daily - 30 mg.

Single doses for children per 1 kg of body weight: newborns and infants - 0.035 mg / kg (0.0175 ml / kg), 1-5 years - 0.03 mg / kg (0.015 ml / kg), 6-10 years - 0,025 mg / kg (0,0125 ml / kg), 11-14 years - 0,02 mg / kg (0,01 ml / kg).

The highest daily doses for children: newborns and nurses - 0.07 mg / kg, 1-5 years - 0.06 mg / kg. 6-10 years-0.05 mg / kg, 11-14 years-0.04 mg / kg.

Side effects:

Dry mouth, thirst, lowering of arterial pressure, tachycardia, mydriasis, accommodation paralysis, intestinal atony, dizziness, headache, photophobia, convulsions; retention of urine; acute psychosis (in high doses); atelectasis of the lung.

Overdose:

Symptoms: paralytic intestinal obstruction, acute urinary retention (in patients with prostate adenoma), paralysis of accommodation, increased intraocular pressure; dryness of the oral mucosa, nose, throat, difficulty swallowing, speech, mydriasis (until the iris completely disappears), tremor, convulsions, hyperthermia, agitation, central nervous system depression, inhibition of respiratory and vasomotor centers.

Treatment: forced diuresis, parenteral administration of cholinostimulators and anticholinesterase drugs. At a hyperthermia - wet wipes, antipyretic agents; with excitation - iv injection of sodium thiopental or recto-chloral hydrate; with mydriasis - topically, in the form of eye drops phosphacol, physostigmine, pilocarpine. In case of development of an attack of glaucoma immediately 1% solution of pilocarpine is injected into the conjunctival bag every 2 drops and 1/2 ml of 0.05% solution of prosirin 3-4 times a day.

Interaction:

Strengthens the sedative and hypnotic action of phenobarbital, ethaminal sodium, magnesium sulfate. Other m-holinoblokatory, amantadine, haloperidol, phenothiazine, monoamine oxidase inhibitors (MAO), tricyclic antidepressants, and some antihistamines increase the risk of side effects. Antagonism - with anticholinesterase drugs. Morphine intensifies the inhibitory effect on the cardiovascular system; MAO inhibitors - positive chrono- and batmotropic effects; cardiac glycosides - a positive Batmotrope action; quinidine, novocainamide - anticholinergic action. With pain associated with spasms of smooth muscles, the action is strengthened by analgesics, sedatives, tranquilizers; with vascular spasms - hypotensive and sedatives.

Effect on the ability to drive transp. cf. and fur:

During the treatment period it is necessary to refrain from potentially dangerous activities requiring increased attention.

Form release / dosage:A solution for subcutaneous administration of 2 mg / ml in ampoules of 1 ml.

Packaging:

A solution for subcutaneous administration of 2 mg / ml in ampoules of 1 ml. 10 ampoules together with the instructions for use and the ampoule with a knife in a box or a pack of cardboard.

Storage conditions:

List A. In a place protected from light and inaccessible to children.

Shelf life:

5 years.Do not use after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N000502 / 01

Date of registration:27.04.2012

The owner of the registration certificate:VEROPHARM SA VEROPHARM SA Russia

Information update date: & nbsp10.08.2015

Illustrated instructions

Instructions

Platyphylline (Platyphyllin)