Platyphylline (Platyphyllin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substancePlatyphyllinePlatyphylline
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    • Dosage form: & nbsp

    Solution for subcutaneous administration

    Composition:

    In 1 ml of solution contains:

    Platifillin hydrotartrate - 2 mg. Excipient: water for injection.

    Description:

    Transparent colorless liquid.

    Pharmacotherapeutic group:M-holinoblokator.
    ATX: & nbsp

    A.03.A.A   Synthetic holinoblokatory - ethers with tertiary amino group

    Pharmacodynamics:

    M-holinoretseptor blocker. It has a myotropic spasmolytic and weak sedative effect. Reduces the tone of the smooth muscles of the gastrointestinal tract, bronchi. Reduces the secretion of salivary, lacrimal, bronchial, sweat glands. Expands the pupil, causes a moderately pronounced paralysis of accommodation and increased intraocular pressure.

    Indications:

    Peptic ulcer of the stomach and duodenum; for relief of bouts of spasmodic pain (intestinal, hepatic, renal colic); as an auxiliary agent for bronchospasm in patients with bronchial asthma.

    Contraindications:

    Hypersensitivity.

    Carefully:

    With caution - pregnancy, lactation, angle-closure glaucoma, cachexia, severe atherosclerosis, heart failure II-III st., arrhythmia, tachycardia; prostate adenoma; hepatic and / or renal insufficiency; pyloroduodenal stenosis, diaphragmatic hernia in combination with reflux esophagitis, paralytic ileus, intestinal atony, bleeding from the digestive tract, megacolon complicated with ulcerative colitis; elderly and senile age.

    Dosing and Administration:

    For relief of acute pain in gastric ulcer and duodenal ulcer, intestinal, hepatic and renal colic, the drug is administered under the skin for 1-2 ml of 0.2% solution. For the course treatment (10-20 days), subcutaneously 1-2 ml 0,2% solution 2-3 times a day.

    The highest dose for adults: single dose - 10 mg, daily - 30 mg.

    Single doses for children per 1 kg of body weight: newborns and infants - 0.035 mg / kg (0.0175 ml / kg), 1-5 years - 0.03 mg / kg (0.015 ml / kg), 6-10 years - 0,025 mg / kg (0,0125 ml / kg), 11-14 years - 0,02 mg / kg (0,01 ml / kg).

    Side effects:

    Dry mouth, thirst, lowering of arterial pressure, tachycardia, mydriasis, accommodation paralysis, intestinal atony, dizziness, headache, photophobia, convulsions; retention of urine; acute psychosis (in high doses); atelectasis of the lung.

    Overdose:

    Symptoms: paralytic intestinal obstruction, acute urinary retention (in patients with prostate adenoma), paralysis of accommodation, increased intraocular pressure; dryness of the oral mucosa, nose, throat, difficulty swallowing, speech, mydriasis (to the complete disappearance of the iris), tremor, convulsions, hyperthermia, excitation, CNS depression, suppression of respiratory and vasomotor centers.

    Treatment: forced diuresis, parenteral administration of cholinostimulators and anticholinesterase drugs. At a hyperthermia - wet wipes, antipyretic agents; with excitation - iv injection of sodium thiopental or rectal - chloral hydrate; with mydriasis - topically, in the form of eye drops phosphacol, physostigmine, pilocarpine. In case of development of an attack of glaucoma immediately 1% solution of pilocarpine is injected into the conjunctival bag every 2 drops and 1/2 ml of 0.05% solution of prozerol 3-4 times inday.

    Interaction:

    Strengthens the sedative and hypnotic action of phenobarbital, ethaminal sodium, magnesium sulfate. Other m-holinoblokatory, amantadine, haloperidol, phenothiazine, MAO inhibitors, tricyclic antidepressants, some antihistamines increase the risk of side effects. Antagonism - with anticholinesterase drugs. Morphine intensifies the inhibitory effect on the cardiovascular system, MAO inhibitors - positive chrono- and batmotropic effects; cardiac glycosides - a positive Batmotrope action; quinidine, novocainamide - anticholinergic action. With pain associated with spasms of smooth muscles, the action is strengthened by analgesics, sedatives, tranquilizers; with vascular spasms - hypotensive and sedatives.

    Effect on the ability to drive transp. cf. and fur:

    During the treatment period it is necessary to refrain from potentially dangerous activities requiring increased attention.

    Form release / dosage:

    Solution in ampoules of 1 ml.

    Packaging:

    5 ampoules in the outline of the cell. 1-2 contour packs with instructions for use in a pack of cardboard.

    Storage conditions:

    List A.

    In a place protected from light and inaccessible to children.

    Shelf life:5 years. Do not use after the expiry date printed on the package.
    Terms of leave from pharmacies:On prescription
    Registration number:P N002840 / 01
    Date of registration:03.10.2008
    The owner of the registration certificate:MOSCOW ENDOCRINE FACTORY, FSUE MOSCOW ENDOCRINE FACTORY, FSUE Russia
    Manufacturer: & nbsp
    Information update date: & nbsp10.08.2015
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